| # | % | |||||
|---|---|---|---|---|---|---|
| 51 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 104,994 | 1,162,000 | 0.38% | ||
| 52 | Bank of New York Mellon Corp | 105,549 | 1,167,000 | 0.38% | ||
| 53 | TIAA CREF INVESTMENT MANAGEMENT LLC | 121,549 | 1,344,000 | 0.44% | ||
| 54 | JPMORGAN CHASE & CO | 124,880 | 1,381,000 | 0.45% | ||
| 55 | DEUTSCHE BANK AG\ | 137,544 | 1,519,000 | 0.50% | ||
| 56 | ROYCE & ASSOCIATES LP | 156,412 | 1,730,000 | 0.57% | ||
| 57 | RENAISSANCE TECHNOLOGIES LLC | 192,200 | 2,126,000 | 0.70% | ||
| 58 | GEODE CAPITAL MANAGEMENT, LLC | 249,737 | 2,761,000 | 0.91% | ||
| 59 | HighTower Advisors, LLC | 252,744 | 2,792,000 | 0.92% | ||
| 60 | NORTHERN TRUST CORP | 311,704 | 3,448,000 | 1.14% | ||
| 61 | STATE STREET CORP | 403,962 | 4,470,000 | 1.47% | ||
| 62 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 440,000 | 4,866,000 | 1.60% | ||
| 63 | ORBIMED ADVISORS LLC | 456,666 | 5,051,000 | 1.66% | ||
| 64 | PERCEPTIVE ADVISORS LLC | 480,000 | 5,309,000 | 1.75% | ||
| 65 | MILLENNIUM MANAGEMENT LLC | 636,785 | 7,043,000 | 2.32% | ||
| 66 | ARK INVESTMENT MANAGEMENT LLC | 752,981 | 8,328,000 | 2.74% | ||
| 67 | Redmile Group, LLC | 812,240 | 8,983,000 | 2.96% | ||
| 68 | Rock Springs Capital Management LP | 1,200,000 | 13,272,000 | 4.37% | ||
| 69 | VANGUARD GROUP INC | 1,206,266 | 13,341,000 | 4.39% | ||
| 70 | Camber Capital Management LP | 2,398,123 | 26,523,000 | 8.74% | ||
| 71 | WELLINGTON MANAGEMENT GROUP LLP | 3,974,227 | 43,955,000 | 14.48% | ||
| 72 | BlackRock Finance, Inc. | 4,485,043 | 49,604,000 | 16.34% | ||
| 73 | BAKER BROS. ADVISORS LP | 7,288,300 | 80,609,000 | 26.55% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
