| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 7,288,300 | 80,609,000 | 26.55% | ||
| 2 | BlackRock Finance, Inc. | 4,485,043 | 49,604,000 | 16.34% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 3,974,227 | 43,955,000 | 14.48% | ||
| 4 | Camber Capital Management LP | 2,398,123 | 26,523,000 | 8.74% | ||
| 5 | VANGUARD GROUP INC | 1,206,266 | 13,341,000 | 4.39% | ||
| 6 | Rock Springs Capital Management LP | 1,200,000 | 13,272,000 | 4.37% | ||
| 7 | Redmile Group, LLC | 812,240 | 8,983,000 | 2.96% | ||
| 8 | ARK INVESTMENT MANAGEMENT LLC | 752,981 | 8,328,000 | 2.74% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 636,785 | 7,043,000 | 2.32% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 480,000 | 5,309,000 | 1.75% | ||
| 11 | ORBIMED ADVISORS LLC | 456,666 | 5,051,000 | 1.66% | ||
| 12 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 440,000 | 4,866,000 | 1.60% | ||
| 13 | STATE STREET CORP | 403,962 | 4,470,000 | 1.47% | ||
| 14 | NORTHERN TRUST CORP | 311,704 | 3,448,000 | 1.14% | ||
| 15 | HighTower Advisors, LLC | 252,744 | 2,792,000 | 0.92% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 249,737 | 2,761,000 | 0.91% | ||
| 17 | RENAISSANCE TECHNOLOGIES LLC | 192,200 | 2,126,000 | 0.70% | ||
| 18 | ROYCE & ASSOCIATES LP | 156,412 | 1,730,000 | 0.57% | ||
| 19 | DEUTSCHE BANK AG\ | 137,544 | 1,519,000 | 0.50% | ||
| 20 | JPMORGAN CHASE & CO | 124,880 | 1,381,000 | 0.45% | ||
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 121,549 | 1,344,000 | 0.44% | ||
| 22 | Bank of New York Mellon Corp | 105,549 | 1,167,000 | 0.38% | ||
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 104,994 | 1,162,000 | 0.38% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 80,800 | 894,000 | 0.29% | Put | |
| 25 | ACUTA CAPITAL PARTNERS, LLC | 70,000 | 774,000 | 0.25% | Put | |
| 26 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,609 | 615,000 | 0.20% | ||
| 27 | ROYAL BANK OF CANADA | 54,739 | 605,000 | 0.20% | ||
| 28 | WELLS FARGO & COMPANY/MN | 53,235 | 589,000 | 0.19% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 51,477 | 569,000 | 0.19% | ||
| 30 | Teton Advisors, Inc. | 51,000 | 564,000 | 0.19% | ||
| 31 | MORGAN STANLEY | 50,769 | 562,000 | 0.19% | ||
| 32 | TEACHERS ADVISORS, LLC | 50,784 | 562,000 | 0.19% | ||
| 33 | ACUTA CAPITAL PARTNERS, LLC | 50,000 | 553,000 | 0.18% | Call | |
| 34 | WOLVERINE TRADING LP /BD | 37,800 | 421,000 | 0.14% | Put | |
| 35 | A.R.T. Advisors, LLC | 37,768 | 417,000 | 0.14% | ||
| 36 | Allianz Asset Management GmbH | 34,968 | 387,000 | 0.13% | ||
| 37 | WOLVERINE TRADING LP /BD | 31,100 | 347,000 | 0.11% | Call | |
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,400 | 336,000 | 0.11% | Call | |
| 39 | RHUMBLINE ADVISERS | 28,841 | 319,000 | 0.11% | ||
| 40 | GAMCO INVESTORS, INC. ET AL | 28,595 | 316,000 | 0.10% | ||
| 41 | SIMPLEX TRADING, LLC | 28,409 | 314,000 | 0.10% | ||
| 42 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 27,252 | 302,000 | 0.10% | ||
| 43 | CREDIT SUISSE AG/ | 25,178 | 279,000 | 0.09% | ||
| 44 | WOLVERINE TRADING LP /BD | 24,715 | 276,000 | 0.09% | ||
| 45 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 23,885 | 264,000 | 0.09% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 23,501 | 260,000 | 0.09% | ||
| 47 | METROPOLITAN LIFE INSURANCE CO/NY | 23,109 | 256,000 | 0.08% | ||
| 48 | GOLDMAN SACHS GROUP INC | 20,688 | 229,000 | 0.08% | ||
| 49 | CUTLER GROUP LLC / CA | 19,090 | 211,000 | 0.07% | ||
| 50 | Trexquant Investment LP | 18,052 | 200,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
