| 1 |
FMR LLC |
1,640,892 |
20,446,000 |
22.88% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
971,730 |
12,108,000 |
13.55% |
|
|
| 3 |
TimesSquare Capital Management, LLC |
801,225 |
9,983,000 |
11.17% |
|
|
| 4 |
EVENTIDE ASSET MANAGEMENT, LLC |
579,800 |
7,224,000 |
8.08% |
|
|
| 5 |
BAKER BROS. ADVISORS LP |
338,671 |
4,220,000 |
4.72% |
|
|
| 6 |
VANGUARD GROUP INC |
300,430 |
3,743,000 |
4.19% |
|
|
| 7 |
GOLDMAN SACHS GROUP INC |
296,417 |
3,693,000 |
4.13% |
|
|
| 8 |
BlackRock Fund Advisors |
273,698 |
3,410,000 |
3.82% |
|
|
| 9 |
STATE STREET CORP |
181,079 |
2,254,000 |
2.52% |
|
|
| 10 |
Artal Group S.A. |
170,000 |
2,118,000 |
2.37% |
|
|
| 11 |
Visium Asset Management, LP |
150,000 |
1,869,000 |
2.09% |
|
|
| 12 |
MILLENNIUM MANAGEMENT LLC |
122,502 |
1,526,000 |
1.71% |
|
|
| 13 |
NORTHERN TRUST CORP |
122,517 |
1,526,000 |
1.71% |
|
|
| 14 |
TFS CAPITAL LLC |
120,112 |
1,497,000 |
1.68% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
106,742 |
1,330,000 |
1.49% |
|
|
| 16 |
RENAISSANCE TECHNOLOGIES LLC |
99,300 |
1,237,000 |
1.38% |
|
|
| 17 |
FARALLON CAPITAL MANAGEMENT LLC |
95,000 |
1,184,000 |
1.33% |
|
|
| 18 |
Invesco Ltd. |
78,151 |
974,000 |
1.09% |
|
|
| 19 |
VHCP Management, LLC |
71,000 |
884,000 |
0.99% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
56,481 |
703,000 |
0.79% |
|
|
| 21 |
PRICE T ROWE ASSOCIATES INC /MD/ |
54,473 |
679,000 |
0.76% |
|
|
| 22 |
Bank of New York Mellon Corp |
49,002 |
610,000 |
0.68% |
|
|
| 23 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
44,098 |
549,000 |
0.61% |
|
|
| 24 |
BlackRock Investment Management, LLC |
34,058 |
424,000 |
0.47% |
|
|
| 25 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
31,100 |
388,000 |
0.43% |
|
|
| 26 |
Private Capital Advisors, Inc. |
31,064 |
387,000 |
0.43% |
|
|
| 27 |
DUPONT CAPITAL MANAGEMENT CORP |
28,930 |
360,000 |
0.40% |
|
|
| 28 |
Compagnie Lombard Odier SCmA |
22,800 |
284,000 |
0.32% |
|
|
| 29 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
22,500 |
280,000 |
0.31% |
|
|
| 30 |
CARL DOMINO INC |
22,196 |
277,000 |
0.31% |
|
|
| 31 |
C WorldWide Group Holding A/S |
21,350 |
265,000 |
0.30% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
21,262 |
265,000 |
0.30% |
|
|
| 33 |
BLACKROCK ADVISORS LLC |
20,324 |
253,000 |
0.28% |
|
|
| 34 |
STONERIDGE INVESTMENT PARTNERS LLC |
19,399 |
242,000 |
0.27% |
|
|
| 35 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
19,143 |
239,000 |
0.27% |
|
|
| 36 |
TEACHERS ADVISORS, LLC |
16,452 |
205,000 |
0.23% |
|
|
| 37 |
Healthcare Value Capital, LLC |
16,464 |
205,000 |
0.23% |
|
|
| 38 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
16,000 |
199,000 |
0.22% |
Put |
|
| 39 |
OAK RIDGE INVESTMENTS LLC |
14,028 |
175,000 |
0.20% |
|
|
| 40 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13,000 |
162,000 |
0.18% |
|
|
| 41 |
AQR CAPITAL MANAGEMENT LLC |
10,400 |
130,000 |
0.15% |
|
|
| 42 |
Capital Impact Advisors, LLC |
10,116 |
126,000 |
0.14% |
|
|
| 43 |
Nationwide Fund Advisors |
8,968 |
112,000 |
0.13% |
|
|
| 44 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
8,664 |
108,000 |
0.12% |
|
|
| 45 |
AMERICAN INTERNATIONAL GROUP, INC. |
7,552 |
94,098 |
0.11% |
|
|
| 46 |
CITADEL ADVISORS LLC |
6,071 |
76,000 |
0.09% |
|
|
| 47 |
MORGAN STANLEY |
6,109 |
76,000 |
0.09% |
|
|
| 48 |
CITIGROUP INC |
4,770 |
60,000 |
0.07% |
|
|
| 49 |
BARCLAYS PLC |
2,936 |
35,000 |
0.04% |
|
|
| 50 |
Tower Research Capital LLC (TRC) |
2,748 |
34,000 |
0.04% |
|
|
