| 1 |
FMR LLC |
1,640,892 |
27,994,000 |
21.50% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
971,730 |
16,578,000 |
12.73% |
|
|
| 3 |
TimesSquare Capital Management, LLC |
840,380 |
14,337,000 |
11.01% |
|
|
| 4 |
EVENTIDE ASSET MANAGEMENT, LLC |
600,500 |
10,245,000 |
7.87% |
|
|
| 5 |
GOLDMAN SACHS GROUP INC |
481,511 |
8,214,000 |
6.31% |
|
|
| 6 |
VHCP Management, LLC |
356,400 |
6,080,000 |
4.67% |
|
|
| 7 |
BAKER BROS. ADVISORS LP |
338,671 |
5,778,000 |
4.44% |
|
|
| 8 |
BlackRock Fund Advisors |
329,254 |
5,617,000 |
4.31% |
|
|
| 9 |
VANGUARD GROUP INC |
308,883 |
5,269,000 |
4.05% |
|
|
| 10 |
STATE STREET CORP |
181,259 |
3,089,000 |
2.37% |
|
|
| 11 |
MILLENNIUM MANAGEMENT LLC |
163,407 |
2,788,000 |
2.14% |
|
|
| 12 |
BALYASNY ASSET MANAGEMENT L.P. |
149,477 |
2,550,000 |
1.96% |
|
|
| 13 |
Invesco Ltd. |
128,896 |
2,199,000 |
1.69% |
|
|
| 14 |
NORTHERN TRUST CORP |
121,314 |
2,069,000 |
1.59% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
103,631 |
1,768,000 |
1.36% |
|
|
| 16 |
FARALLON CAPITAL MANAGEMENT LLC |
95,000 |
1,621,000 |
1.24% |
|
|
| 17 |
Opus Point Partners Management, LLC |
70,400 |
1,201,000 |
0.92% |
|
|
| 18 |
MACKENZIE FINANCIAL CORP |
64,100 |
1,094,000 |
0.84% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
61,229 |
1,044,000 |
0.80% |
|
|
| 20 |
TFS CAPITAL LLC |
55,507 |
947,000 |
0.73% |
|
|
| 21 |
Bank of New York Mellon Corp |
54,601 |
932,000 |
0.72% |
|
|
| 22 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
44,115 |
753,000 |
0.58% |
|
|
| 23 |
Telemetry Investments, L.L.C. |
37,000 |
631,000 |
0.48% |
|
|
| 24 |
BlackRock Investment Management, LLC |
33,943 |
579,000 |
0.44% |
|
|
| 25 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
31,100 |
443,000 |
0.34% |
|
|
| 26 |
STONERIDGE INVESTMENT PARTNERS LLC |
24,189 |
413,000 |
0.32% |
|
|
| 27 |
CREDIT SUISSE AG/ |
23,809 |
406,000 |
0.31% |
|
|
| 28 |
DUPONT CAPITAL MANAGEMENT CORP |
22,980 |
392,000 |
0.30% |
|
|
| 29 |
Compagnie Lombard Odier SCmA |
22,800 |
389,000 |
0.30% |
|
|
| 30 |
C WorldWide Group Holding A/S |
21,350 |
364,000 |
0.28% |
|
|
| 31 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
21,353 |
364,000 |
0.28% |
|
|
| 32 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
19,000 |
324,000 |
0.25% |
|
|
| 33 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
18,408 |
314,000 |
0.24% |
|
|
| 34 |
Healthcare Value Capital, LLC |
16,464 |
281,000 |
0.22% |
|
|
| 35 |
TEACHERS ADVISORS, LLC |
16,452 |
281,000 |
0.22% |
|
|
| 36 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
16,150 |
276,000 |
0.21% |
|
|
| 37 |
CARL DOMINO INC |
14,796 |
252,000 |
0.19% |
|
|
| 38 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13,000 |
222,000 |
0.17% |
|
|
| 39 |
CANADA LIFE ASSURANCE Co |
12,900 |
220,000 |
0.17% |
|
|
| 40 |
OAK RIDGE INVESTMENTS LLC |
12,771 |
218,000 |
0.17% |
|
|
| 41 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
12,328 |
210,000 |
0.16% |
|
|
| 42 |
Capital Impact Advisors, LLC |
10,116 |
173,000 |
0.13% |
|
|
| 43 |
Eagle Ridge Investment Management |
10,000 |
171,000 |
0.13% |
|
|
| 44 |
MORGAN STANLEY |
9,143 |
156,000 |
0.12% |
|
|
| 45 |
Nationwide Fund Advisors |
8,968 |
153,000 |
0.12% |
|
|
| 46 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
7,844 |
134,000 |
0.10% |
|
|
| 47 |
AMERICAN INTERNATIONAL GROUP, INC. |
7,264 |
123,924 |
0.10% |
|
|
| 48 |
CITIGROUP INC |
6,226 |
107,000 |
0.08% |
|
|
| 49 |
DEUTSCHE BANK AG\ |
5,807 |
98,000 |
0.08% |
|
|
| 50 |
BLACKROCK ADVISORS LLC |
5,652 |
96,000 |
0.07% |
|
|
