| 1 |
FMR LLC |
1,861,914 |
16,441,000 |
16.98% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
1,558,530 |
13,762,000 |
14.21% |
|
|
| 3 |
TimesSquare Capital Management, LLC |
1,195,280 |
10,554,000 |
10.90% |
|
|
| 4 |
EVENTIDE ASSET MANAGEMENT, LLC |
735,000 |
6,490,000 |
6.70% |
|
|
| 5 |
FARALLON CAPITAL MANAGEMENT LLC |
676,162 |
5,971,000 |
6.17% |
|
|
| 6 |
GREAT POINT PARTNERS LLC |
475,200 |
4,196,000 |
4.33% |
|
|
| 7 |
GOLDMAN SACHS GROUP INC |
466,476 |
4,119,000 |
4.25% |
|
|
| 8 |
VANGUARD GROUP INC |
458,336 |
4,047,000 |
4.18% |
|
|
| 9 |
VHCP Management, LLC |
451,400 |
3,986,000 |
4.12% |
|
|
| 10 |
BlackRock Fund Advisors |
391,825 |
3,460,000 |
3.57% |
|
|
| 11 |
BAKER BROS. ADVISORS LP |
333,497 |
2,945,000 |
3.04% |
|
|
| 12 |
MACKENZIE FINANCIAL CORP |
208,500 |
1,841,000 |
1.90% |
|
|
| 13 |
STATE STREET CORP |
191,774 |
1,693,000 |
1.75% |
|
|
| 14 |
MILLENNIUM MANAGEMENT LLC |
189,480 |
1,673,000 |
1.73% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
176,296 |
1,557,000 |
1.61% |
|
|
| 16 |
NORTHERN TRUST CORP |
169,391 |
1,496,000 |
1.54% |
|
|
| 17 |
Invesco Ltd. |
133,221 |
1,177,000 |
1.22% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
104,950 |
926,000 |
0.96% |
|
|
| 19 |
PERCEPTIVE ADVISORS LLC |
78,603 |
694,000 |
0.72% |
|
|
| 20 |
Telemetry Investments, L.L.C. |
77,000 |
680,000 |
0.70% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
75,069 |
663,000 |
0.68% |
|
|
| 22 |
Opus Point Partners Management, LLC |
75,000 |
662,000 |
0.68% |
|
|
| 23 |
BAILARD, INC. |
64,785 |
572,000 |
0.59% |
|
|
| 24 |
Compagnie Lombard Odier SCmA |
60,500 |
534,000 |
0.55% |
|
|
| 25 |
BlackRock Investment Management, LLC |
57,934 |
512,000 |
0.53% |
|
|
| 26 |
Bank of New York Mellon Corp |
54,516 |
482,000 |
0.50% |
|
|
| 27 |
STONERIDGE INVESTMENT PARTNERS LLC |
53,870 |
476,000 |
0.49% |
|
|
| 28 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
45,500 |
402,000 |
0.42% |
|
|
| 29 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
45,100 |
398,000 |
0.41% |
Put |
|
| 30 |
ROYCE & ASSOCIATES LP |
38,000 |
336,000 |
0.35% |
|
|
| 31 |
TFS CAPITAL LLC |
37,372 |
330,000 |
0.34% |
|
|
| 32 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
32,505 |
287,000 |
0.30% |
|
|
| 33 |
NEW YORK STATE COMMON RETIREMENT FUND |
31,200 |
275,000 |
0.28% |
|
|
| 34 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
31,100 |
275,000 |
0.28% |
|
|
| 35 |
EDMOND DE ROTHSCHILD (SUISSE) S.A. |
30,000 |
265,000 |
0.27% |
|
|
| 36 |
EDMOND DE ROTHSCHILD HOLDING S.A. |
30,000 |
265,000 |
0.27% |
|
|
| 37 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
28,432 |
251,000 |
0.26% |
|
|
| 38 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
28,000 |
248,000 |
0.26% |
|
|
| 39 |
Healthcare Value Capital, LLC |
25,000 |
221,000 |
0.23% |
|
|
| 40 |
TEACHERS ADVISORS, LLC |
22,853 |
202,000 |
0.21% |
|
|
| 41 |
A.R.T. Advisors, LLC |
21,679 |
191,000 |
0.20% |
|
|
| 42 |
MORGAN STANLEY |
21,370 |
189,000 |
0.20% |
|
|
| 43 |
RHUMBLINE ADVISERS |
19,202 |
170,000 |
0.18% |
|
|
| 44 |
OAK RIDGE INVESTMENTS LLC |
13,641 |
120,000 |
0.12% |
|
|
| 45 |
BLACKROCK ADVISORS LLC |
10,986 |
97,000 |
0.10% |
|
|
| 46 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
10,880 |
96,000 |
0.10% |
|
|
| 47 |
Nationwide Fund Advisors |
10,185 |
90,000 |
0.09% |
|
|
| 48 |
Connor, Clark & Lunn Investment Management Ltd. |
10,100 |
89,000 |
0.09% |
|
|
| 49 |
GROUP ONE TRADING LLC |
9,997 |
88,000 |
0.09% |
|
|
| 50 |
AMERICAN INTERNATIONAL GROUP, INC. |
9,167 |
81,000 |
0.08% |
|
|
