| 1 |
FMR LLC |
1,965,892 |
28,446,000 |
17.08% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
1,321,730 |
19,125,000 |
11.49% |
|
|
| 3 |
TimesSquare Capital Management, LLC |
1,311,880 |
18,983,000 |
11.40% |
|
|
| 4 |
FARALLON CAPITAL MANAGEMENT LLC |
672,562 |
9,732,000 |
5.85% |
|
|
| 5 |
EVENTIDE ASSET MANAGEMENT, LLC |
620,200 |
8,974,000 |
5.39% |
|
|
| 6 |
GREAT POINT PARTNERS LLC |
475,200 |
6,877,000 |
4.13% |
|
|
| 7 |
Avoro Capital Advisors LLC |
475,000 |
6,873,000 |
4.13% |
|
|
| 8 |
GOLDMAN SACHS GROUP INC |
461,799 |
6,682,000 |
4.01% |
|
|
| 9 |
VHCP Management, LLC |
451,400 |
6,532,000 |
3.92% |
|
|
| 10 |
VANGUARD GROUP INC |
428,954 |
6,207,000 |
3.73% |
|
|
| 11 |
BlackRock Fund Advisors |
412,243 |
5,965,000 |
3.58% |
|
|
| 12 |
BAKER BROS. ADVISORS LP |
333,497 |
4,826,000 |
2.90% |
|
|
| 13 |
MILLENNIUM MANAGEMENT LLC |
333,412 |
4,824,000 |
2.90% |
|
|
| 14 |
TFS CAPITAL LLC |
259,916 |
3,761,000 |
2.26% |
|
|
| 15 |
STATE STREET CORP |
181,230 |
2,622,000 |
1.57% |
|
|
| 16 |
NORTHERN TRUST CORP |
143,142 |
2,072,000 |
1.24% |
|
|
| 17 |
Sio Capital Management, LLC |
140,000 |
2,026,000 |
1.22% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
140,007 |
2,026,000 |
1.22% |
|
|
| 19 |
Invesco Ltd. |
132,205 |
1,913,000 |
1.15% |
|
|
| 20 |
MACKENZIE FINANCIAL CORP |
99,400 |
1,438,000 |
0.86% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
90,704 |
1,312,000 |
0.79% |
|
|
| 22 |
SPHERA FUNDS MANAGEMENT LTD. |
80,957 |
1,171,000 |
0.70% |
|
|
| 23 |
PERCEPTIVE ADVISORS LLC |
79,245 |
1,147,000 |
0.69% |
|
|
| 24 |
Bank of New York Mellon Corp |
79,263 |
1,147,000 |
0.69% |
|
|
| 25 |
Opus Point Partners Management, LLC |
75,000 |
1,085,000 |
0.65% |
|
|
| 26 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
58,508 |
847,000 |
0.51% |
|
|
| 27 |
Telemetry Investments, L.L.C. |
55,000 |
796,000 |
0.48% |
|
|
| 28 |
BAILARD, INC. |
50,000 |
724,000 |
0.43% |
|
|
| 29 |
BlackRock Investment Management, LLC |
43,138 |
624,000 |
0.37% |
|
|
| 30 |
STONERIDGE INVESTMENT PARTNERS LLC |
38,932 |
563,000 |
0.34% |
|
|
| 31 |
DEERE & CO |
34,655 |
501,000 |
0.30% |
|
|
| 32 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
34,000 |
492,000 |
0.30% |
|
|
| 33 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
32,650 |
472,000 |
0.28% |
|
|
| 34 |
Nationwide Fund Advisors |
31,974 |
463,000 |
0.28% |
|
|
| 35 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
31,100 |
443,000 |
0.27% |
|
|
| 36 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
28,000 |
406,000 |
0.24% |
|
|
| 37 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
27,053 |
391,000 |
0.23% |
|
|
| 38 |
Healthcare Value Capital, LLC |
25,000 |
362,000 |
0.22% |
|
|
| 39 |
DUPONT CAPITAL MANAGEMENT CORP |
24,370 |
353,000 |
0.21% |
|
|
| 40 |
Compagnie Lombard Odier SCmA |
22,800 |
330,000 |
0.20% |
|
|
| 41 |
TEACHERS ADVISORS, LLC |
21,955 |
318,000 |
0.19% |
|
|
| 42 |
NEW YORK STATE COMMON RETIREMENT FUND |
17,000 |
246,000 |
0.15% |
|
|
| 43 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
16,457 |
238,000 |
0.14% |
|
|
| 44 |
RHUMBLINE ADVISERS |
13,598 |
197,000 |
0.12% |
|
|
| 45 |
OAK RIDGE INVESTMENTS LLC |
13,641 |
197,000 |
0.12% |
|
|
| 46 |
METROPOLITAN LIFE INSURANCE CO/NY |
12,765 |
185,000 |
0.11% |
|
|
| 47 |
CARL DOMINO INC |
12,796 |
185,000 |
0.11% |
|
|
| 48 |
CANADA LIFE ASSURANCE Co |
12,500 |
180,000 |
0.11% |
|
|
| 49 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
11,750 |
170,000 |
0.10% |
|
|
| 50 |
Connor, Clark & Lunn Investment Management Ltd. |
11,600 |
168,000 |
0.10% |
|
|
