| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,861,392 | 20,159,000 | 20.76% | ||
| 2 | FRANKLIN RESOURCES INC | 1,642,197 | 17,785,000 | 18.31% | ||
| 3 | EVENTIDE ASSET MANAGEMENT, LLC | 851,400 | 9,221,000 | 9.50% | ||
| 4 | VANGUARD GROUP INC | 594,677 | 6,440,000 | 6.63% | ||
| 5 | BlackRock Fund Advisors | 471,055 | 5,102,000 | 5.25% | ||
| 6 | BAKER BROS. ADVISORS LP | 333,497 | 3,612,000 | 3.72% | ||
| 7 | VHCP MANAGEMENT II, LLC | 315,980 | 3,422,000 | 3.52% | ||
| 8 | Candriam S.C.A. | 257,000 | 2,783,000 | 2.87% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 239,232 | 2,591,000 | 2.67% | ||
| 10 | STATE STREET CORP | 230,508 | 2,493,000 | 2.57% | ||
| 11 | NORTHERN TRUST CORP | 187,393 | 2,029,000 | 2.09% | ||
| 12 | COLUMBUS CIRCLE INVESTORS | 145,596 | 1,577,000 | 1.62% | ||
| 13 | DEUTSCHE BANK AG\ | 138,748 | 1,502,000 | 1.55% | ||
| 14 | VHCP Management, LLC | 135,420 | 1,467,000 | 1.51% | ||
| 15 | Invesco Ltd. | 122,422 | 1,326,000 | 1.37% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 113,770 | 1,232,000 | 1.27% | ||
| 17 | SABBY MANAGEMENT, LLC | 98,050 | 1,062,000 | 1.09% | ||
| 18 | BAILARD, INC. | 94,785 | 1,027,000 | 1.06% | ||
| 19 | DIMENSIONAL FUND ADVISORS LP | 81,819 | 886,000 | 0.91% | ||
| 20 | ROYCE & ASSOCIATES LP | 78,679 | 852,000 | 0.88% | ||
| 21 | BlackRock Investment Management, LLC | 73,893 | 800,000 | 0.82% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 64,768 | 701,000 | 0.72% | ||
| 23 | RENAISSANCE TECHNOLOGIES LLC | 60,700 | 657,000 | 0.68% | ||
| 24 | Compagnie Lombard Odier SCmA | 60,500 | 655,000 | 0.67% | ||
| 25 | JACOBS LEVY EQUITY MANAGEMENT, INC | 51,243 | 555,000 | 0.57% | ||
| 26 | MILLENNIUM MANAGEMENT LLC | 50,541 | 547,000 | 0.56% | ||
| 27 | Bank of New York Mellon Corp | 49,733 | 539,000 | 0.56% | ||
| 28 | MACKENZIE FINANCIAL CORP | 36,899 | 400,000 | 0.41% | ||
| 29 | ACADIAN ASSET MANAGEMENT LLC | 36,929 | 400,000 | 0.41% | ||
| 30 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,649 | 386,000 | 0.40% | ||
| 31 | STONERIDGE INVESTMENT PARTNERS LLC | 33,725 | 365,000 | 0.38% | ||
| 32 | NEW YORK STATE COMMON RETIREMENT FUND | 31,200 | 338,000 | 0.35% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 31,100 | 337,000 | 0.35% | ||
| 34 | D. E. Shaw & Co., Inc. | 28,646 | 310,000 | 0.32% | ||
| 35 | TEACHERS ADVISORS, LLC | 26,913 | 291,000 | 0.30% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 26,000 | 282,000 | 0.29% | ||
| 37 | RHUMBLINE ADVISERS | 25,107 | 272,000 | 0.28% | ||
| 38 | CARL DOMINO INC | 26,000 | 267,000 | 0.27% | ||
| 39 | PARADIGM ASSET MANAGEMENT CO LLC | 23,500 | 254,505 | 0.26% | ||
| 40 | TFS CAPITAL LLC | 23,324 | 253,000 | 0.26% | ||
| 41 | Telemetry Investments, L.L.C. | 23,000 | 249,000 | 0.26% | ||
| 42 | STATE OF MICHIGAN RETIREMENT SYSTEM | 20,000 | 217,000 | 0.22% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,700 | 170,000 | 0.18% | Put | |
| 44 | OAK RIDGE INVESTMENTS LLC | 12,796 | 139,000 | 0.14% | ||
| 45 | GOLDMAN SACHS GROUP INC | 12,158 | 132,000 | 0.14% | ||
| 46 | Nationwide Fund Advisors | 11,042 | 120,000 | 0.12% | ||
| 47 | PERCEPTIVE ADVISORS LLC | 10,702 | 116,000 | 0.12% | ||
| 48 | AMERICAN INTERNATIONAL GROUP, INC. | 9,719 | 105,257 | 0.11% | ||
| 49 | BLACKROCK ADVISORS LLC | 9,000 | 97,000 | 0.10% | ||
| 50 | UBS Group AG | 8,311 | 90,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
