| 1 |
FMR LLC |
1,861,392 |
21,909,000 |
16.73% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
1,558,530 |
18,344,000 |
14.01% |
|
|
| 3 |
TimesSquare Capital Management, LLC |
1,224,180 |
14,409,000 |
11.01% |
|
|
| 4 |
EVENTIDE ASSET MANAGEMENT, LLC |
704,250 |
8,289,000 |
6.33% |
|
|
| 5 |
FARALLON CAPITAL MANAGEMENT LLC |
672,562 |
7,916,000 |
6.05% |
|
|
| 6 |
GREAT POINT PARTNERS LLC |
475,200 |
5,593,000 |
4.27% |
|
|
| 7 |
GOLDMAN SACHS GROUP INC |
460,928 |
5,425,000 |
4.14% |
|
|
| 8 |
VHCP Management, LLC |
451,400 |
5,313,000 |
4.06% |
|
|
| 9 |
VANGUARD GROUP INC |
435,613 |
5,127,000 |
3.92% |
|
|
| 10 |
BlackRock Fund Advisors |
396,517 |
4,667,000 |
3.56% |
|
|
| 11 |
MILLENNIUM MANAGEMENT LLC |
348,980 |
4,107,000 |
3.14% |
|
|
| 12 |
BAKER BROS. ADVISORS LP |
333,497 |
3,925,000 |
3.00% |
|
|
| 13 |
STATE STREET CORP |
189,380 |
2,228,000 |
1.70% |
|
|
| 14 |
MACKENZIE FINANCIAL CORP |
165,500 |
1,948,000 |
1.49% |
|
|
| 15 |
NORTHERN TRUST CORP |
159,718 |
1,880,000 |
1.44% |
|
|
| 16 |
Invesco Ltd. |
130,393 |
1,535,000 |
1.17% |
|
|
| 17 |
TFS CAPITAL LLC |
129,974 |
1,530,000 |
1.17% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
128,952 |
1,518,000 |
1.16% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
94,363 |
1,110,000 |
0.85% |
|
|
| 20 |
PERCEPTIVE ADVISORS LLC |
79,245 |
933,000 |
0.71% |
|
|
| 21 |
Telemetry Investments, L.L.C. |
79,000 |
930,000 |
0.71% |
|
|
| 22 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
75,069 |
884,000 |
0.68% |
|
|
| 23 |
Opus Point Partners Management, LLC |
75,000 |
883,000 |
0.67% |
|
|
| 24 |
Bank of New York Mellon Corp |
74,420 |
876,000 |
0.67% |
|
|
| 25 |
Compagnie Lombard Odier SCmA |
60,500 |
712,000 |
0.54% |
|
|
| 26 |
BlackRock Investment Management, LLC |
58,402 |
687,000 |
0.52% |
|
|
| 27 |
STONERIDGE INVESTMENT PARTNERS LLC |
54,670 |
643,000 |
0.49% |
|
|
| 28 |
BAILARD, INC. |
50,000 |
589,000 |
0.45% |
|
|
| 29 |
NEW YORK STATE COMMON RETIREMENT FUND |
33,496 |
394,000 |
0.30% |
|
|
| 30 |
A.R.T. Advisors, LLC |
32,655 |
384,000 |
0.29% |
|
|
| 31 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
31,100 |
366,000 |
0.28% |
|
|
| 32 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
31,100 |
366,000 |
0.28% |
|
|
| 33 |
EDMOND DE ROTHSCHILD HOLDING S.A. |
30,000 |
353,000 |
0.27% |
|
|
| 34 |
EDMOND DE ROTHSCHILD (SUISSE) S.A. |
30,000 |
353,000 |
0.27% |
|
|
| 35 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
28,532 |
336,000 |
0.26% |
|
|
| 36 |
DUPONT CAPITAL MANAGEMENT CORP |
28,410 |
334,000 |
0.26% |
|
|
| 37 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
28,000 |
330,000 |
0.25% |
|
|
| 38 |
CANADA LIFE ASSURANCE Co |
25,200 |
297,000 |
0.23% |
|
|
| 39 |
Healthcare Value Capital, LLC |
25,000 |
294,000 |
0.22% |
|
|
| 40 |
TEACHERS ADVISORS, LLC |
22,853 |
269,000 |
0.21% |
|
|
| 41 |
BLACKROCK ADVISORS LLC |
22,669 |
267,000 |
0.20% |
|
|
| 42 |
Nine Chapters Capital Management LLC |
19,000 |
224,000 |
0.17% |
|
|
| 43 |
RHUMBLINE ADVISERS |
18,218 |
214,000 |
0.16% |
|
|
| 44 |
CARL DOMINO INC |
16,796 |
198,000 |
0.15% |
|
|
| 45 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
15,807 |
187,000 |
0.14% |
|
|
| 46 |
MORGAN STANLEY |
13,900 |
164,000 |
0.13% |
|
|
| 47 |
OAK RIDGE INVESTMENTS LLC |
13,641 |
161,000 |
0.12% |
|
|
| 48 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
13,400 |
158,000 |
0.12% |
|
|
| 49 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
13,433 |
158,000 |
0.12% |
|
|
| 50 |
D. E. Shaw & Co., Inc. |
12,342 |
145,000 |
0.11% |
|
|
