| 1 |
SOROS FUND MANAGEMENT LLC |
1,462,122 |
8,773,000 |
21.09% |
|
|
| 2 |
Knoll Capital Management, LLC |
1,359,767 |
8,036,000 |
19.31% |
|
|
| 3 |
PERCEPTIVE ADVISORS LLC |
1,336,050 |
8,016,000 |
19.27% |
|
|
| 4 |
VANGUARD GROUP INC |
567,283 |
3,403,000 |
8.18% |
|
|
| 5 |
MILLENNIUM MANAGEMENT LLC |
393,993 |
2,364,000 |
5.68% |
|
|
| 6 |
ROYCE & ASSOCIATES LP |
374,821 |
2,249,000 |
5.41% |
|
|
| 7 |
NEXTHERA CAPITAL LP |
321,609 |
1,930,000 |
4.64% |
|
|
| 8 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
265,143 |
1,591,000 |
3.82% |
|
|
| 9 |
GEODE CAPITAL MANAGEMENT, LLC |
120,014 |
720,000 |
1.73% |
|
|
| 10 |
BAKER BROS. ADVISORS LP |
101,680 |
610,000 |
1.47% |
|
|
| 11 |
Opaleye Management Inc. |
100,000 |
600,000 |
1.44% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
70,687 |
424,000 |
1.02% |
|
|
| 13 |
GOLDMAN SACHS GROUP INC |
68,452 |
411,000 |
0.99% |
|
|
| 14 |
CAMBRIDGE TRUST CO |
65,414 |
392,000 |
0.94% |
|
|
| 15 |
KAVI ASSET MANAGEMENT, LP |
63,300 |
380,000 |
0.91% |
|
|
| 16 |
BlackRock Fund Advisors |
39,934 |
240,000 |
0.58% |
|
|
| 17 |
Jefferies Group LLC |
35,000 |
210,000 |
0.50% |
|
|
| 18 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
26,942 |
162,000 |
0.39% |
|
|
| 19 |
IFP ADVISORS, INC |
25,004 |
150,000 |
0.36% |
|
|
| 20 |
NORTHERN TRUST CORP |
24,171 |
145,000 |
0.35% |
|
|
| 21 |
DIMENSIONAL FUND ADVISORS LP |
22,977 |
138,000 |
0.33% |
|
|
| 22 |
ARDSLEY ADVISORY PARTNERS LP |
20,000 |
120,000 |
0.29% |
|
|
| 23 |
RTW INVESTMENTS, LP |
19,391 |
116,000 |
0.28% |
|
|
| 24 |
PRELUDE CAPITAL MANAGEMENT, LLC |
18,000 |
108,000 |
0.26% |
|
|
| 25 |
D. E. Shaw & Co., Inc. |
12,429 |
75,000 |
0.18% |
|
|
| 26 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
10,900 |
65,000 |
0.16% |
Call |
|
| 27 |
MORGAN STANLEY |
7,155 |
43,000 |
0.10% |
|
|
| 28 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
5,606 |
34,000 |
0.08% |
|
|
| 29 |
WEALTHPLAN PARTNERS, LLC |
4,643 |
27,904 |
0.07% |
|
|
| 30 |
ADVISOR GROUP, INC. |
3,001 |
18,000 |
0.04% |
|
|
| 31 |
BlackRock Investment Management, LLC |
2,643 |
16,000 |
0.04% |
|
|
| 32 |
Creative Planning |
2,443 |
15,000 |
0.04% |
|
|
| 33 |
Hartford Financial Management Inc. |
2,300 |
13,000 |
0.03% |
|
|
| 34 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
1,000 |
6,000 |
0.01% |
|
|
| 35 |
BANK OF AMERICA CORP /DE/ |
300 |
2,000 |
0.00% |
|
|
| 36 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
131 |
1,000 |
0.00% |
|
|
| 37 |
CITIGROUP INC |
200 |
1,000 |
0.00% |
|
|
| 38 |
WELLS FARGO & COMPANY/MN |
200 |
1,000 |
0.00% |
|
|
| 39 |
WHITTIER TRUST CO |
1 |
0 |
0.00% |
|
|
| 40 |
DEUTSCHE BANK AG\ |
2 |
0 |
0.00% |
|
|
| 41 |
PIERSHALE FINANCIAL GROUP, INC. |
5 |
0 |
0.00% |
|
|
| 42 |
UBS Group AG |
1 |
0 |
0.00% |
|
|
| 43 |
CUTLER GROUP LLC / CA |
100 |
0 |
0.00% |
|
|
