| 1 |
PERCEPTIVE ADVISORS LLC |
1,762,881 |
7,140,000 |
23.67% |
|
|
| 2 |
SOROS FUND MANAGEMENT LLC |
1,462,122 |
5,922,000 |
19.64% |
|
|
| 3 |
Knoll Capital Management, LLC |
1,359,767 |
5,507,000 |
18.26% |
|
|
| 4 |
SPHERA FUNDS MANAGEMENT LTD. |
600,000 |
2,430,000 |
8.06% |
|
|
| 5 |
VANGUARD GROUP INC |
492,968 |
1,997,000 |
6.62% |
|
|
| 6 |
SABBY MANAGEMENT, LLC |
340,702 |
1,380,000 |
4.58% |
|
|
| 7 |
BlackRock Fund Advisors |
271,372 |
1,099,000 |
3.64% |
|
|
| 8 |
DAFNA Capital Management LLC |
181,818 |
736,000 |
2.44% |
|
|
| 9 |
BlackRock Institutional Trust Company, N.A. |
139,041 |
563,000 |
1.87% |
|
|
| 10 |
ACUTA CAPITAL PARTNERS, LLC |
111,342 |
451,000 |
1.50% |
|
|
| 11 |
NORTHERN TRUST CORP |
105,122 |
426,000 |
1.41% |
|
|
| 12 |
STATE STREET CORP |
67,828 |
274,000 |
0.91% |
|
|
| 13 |
CAMBRIDGE TRUST CO |
65,414 |
265,000 |
0.88% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
58,256 |
235,000 |
0.78% |
|
|
| 15 |
ROYCE & ASSOCIATES LP |
57,181 |
232,000 |
0.77% |
|
|
| 16 |
BlackRock Investment Management, LLC |
44,096 |
179,000 |
0.59% |
|
|
| 17 |
MORGAN STANLEY |
36,970 |
149,000 |
0.49% |
|
|
| 18 |
MILLENNIUM MANAGEMENT LLC |
34,279 |
139,000 |
0.46% |
|
|
| 19 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
33,706 |
137,000 |
0.45% |
|
|
| 20 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
33,600 |
136,000 |
0.45% |
Call |
|
| 21 |
Weiss Multi-Strategy Advisers LLC |
25,000 |
101,000 |
0.33% |
|
|
| 22 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
20,670 |
84,000 |
0.28% |
|
|
| 23 |
Bank of New York Mellon Corp |
18,363 |
74,000 |
0.25% |
|
|
| 24 |
PRELUDE CAPITAL MANAGEMENT, LLC |
17,400 |
70,000 |
0.23% |
|
|
| 25 |
ALLIANCEBERNSTEIN L.P. |
15,500 |
63,000 |
0.21% |
|
|
| 26 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
14,621 |
60,000 |
0.20% |
|
|
| 27 |
TEACHERS ADVISORS, LLC |
14,133 |
57,000 |
0.19% |
|
|
| 28 |
CREDIT SUISSE AG/ |
12,824 |
52,000 |
0.17% |
|
|
| 29 |
NEW YORK STATE COMMON RETIREMENT FUND |
9,400 |
38,000 |
0.13% |
|
|
| 30 |
Nationwide Fund Advisors |
6,593 |
27,000 |
0.09% |
|
|
| 31 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,062 |
25,000 |
0.08% |
|
|
| 32 |
GROUP ONE TRADING LLC |
5,365 |
22,000 |
0.07% |
|
|
| 33 |
PRELUDE CAPITAL MANAGEMENT, LLC |
5,400 |
22,000 |
0.07% |
Call |
|
| 34 |
BLACKROCK ADVISORS LLC |
5,239 |
21,000 |
0.07% |
|
|
| 35 |
DEUTSCHE BANK AG\ |
3,159 |
12,000 |
0.04% |
|
|
| 36 |
BNP PARIBAS FINANCIAL MARKETS |
2,572 |
10,417 |
0.03% |
|
|
| 37 |
BANK OF AMERICA CORP /DE/ |
2,073 |
8,000 |
0.03% |
|
|
| 38 |
Walleye Trading LLC |
1,800 |
7,000 |
0.02% |
|
|
| 39 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
1,000 |
4,000 |
0.01% |
|
|
| 40 |
ROYAL BANK OF CANADA |
528 |
2,000 |
0.01% |
|
|
| 41 |
Creative Planning |
400 |
2,000 |
0.01% |
|
|
| 42 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
131 |
1,000 |
0.00% |
|
|
| 43 |
WELLS FARGO & COMPANY/MN |
252 |
1,000 |
0.00% |
|
|
| 44 |
UBS Group AG |
1 |
0 |
0.00% |
|
|
| 45 |
CITIGROUP INC |
9 |
0 |
0.00% |
|
|
| 46 |
BARCLAYS PLC |
60 |
0 |
0.00% |
|
|
| 47 |
PIERSHALE FINANCIAL GROUP, INC. |
5 |
0 |
0.00% |
|
|
