| 1 |
Knoll Capital Management, LLC |
2,359,767 |
11,445,000 |
15.86% |
|
|
| 2 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,950,000 |
9,458,000 |
13.10% |
|
|
| 3 |
BAKER BROS. ADVISORS LP |
1,684,364 |
8,169,000 |
11.32% |
|
|
| 4 |
RA CAPITAL MANAGEMENT, L.P. |
1,142,857 |
5,543,000 |
7.68% |
|
|
| 5 |
VANGUARD GROUP INC |
912,966 |
4,428,000 |
6.13% |
|
|
| 6 |
SOROS FUND MANAGEMENT LLC |
896,642 |
4,349,000 |
6.03% |
|
|
| 7 |
PERCEPTIVE ADVISORS LLC |
842,173 |
4,085,000 |
5.66% |
|
|
| 8 |
NEXTHERA CAPITAL LP |
568,573 |
2,758,000 |
3.82% |
|
|
| 9 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
551,800 |
2,676,000 |
3.71% |
|
|
| 10 |
Cormorant Asset Management, LP |
500,000 |
2,425,000 |
3.36% |
|
|
| 11 |
MILLENNIUM MANAGEMENT LLC |
421,600 |
2,045,000 |
2.83% |
|
|
| 12 |
Opaleye Management Inc. |
400,000 |
1,940,000 |
2.69% |
|
|
| 13 |
KAVI ASSET MANAGEMENT, LP |
365,600 |
1,773,000 |
2.46% |
|
|
| 14 |
CASTLE HOOK PARTNERS LP |
349,800 |
1,697,000 |
2.35% |
|
|
| 15 |
ROYCE & ASSOCIATES LP |
312,221 |
1,514,000 |
2.10% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
202,550 |
982,000 |
1.36% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
191,485 |
928,000 |
1.29% |
|
|
| 18 |
WELLINGTON MANAGEMENT GROUP LLP |
174,290 |
845,000 |
1.17% |
|
|
| 19 |
MOORE CAPITAL MANAGEMENT, LP |
150,000 |
728,000 |
1.01% |
|
|
| 20 |
JENNISON ASSOCIATES LLC |
141,401 |
686,000 |
0.95% |
|
|
| 21 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
77,284 |
375,000 |
0.52% |
|
|
| 22 |
DAFNA Capital Management LLC |
76,800 |
372,000 |
0.52% |
|
|
| 23 |
CAMBRIDGE TRUST CO |
65,414 |
317,000 |
0.44% |
|
|
| 24 |
Allianz Asset Management GmbH |
48,566 |
236,000 |
0.33% |
|
|
| 25 |
NORTHERN TRUST CORP |
43,952 |
213,000 |
0.30% |
|
|
| 26 |
BlackRock Fund Advisors |
41,908 |
203,000 |
0.28% |
|
|
| 27 |
ARDSLEY ADVISORY PARTNERS LP |
40,000 |
194,000 |
0.27% |
|
|
| 28 |
GLG Partners LP |
38,288 |
186,000 |
0.26% |
|
|
| 29 |
TUDOR INVESTMENT CORP ET AL |
33,500 |
162,000 |
0.22% |
|
|
| 30 |
Virtu KCG Holdings LLC |
28,096 |
136,000 |
0.19% |
|
|
| 31 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
27,200 |
132,000 |
0.18% |
Put |
|
| 32 |
IFP ADVISORS, INC |
25,004 |
121,000 |
0.17% |
|
|
| 33 |
Jefferies Group LLC |
25,000 |
121,000 |
0.17% |
|
|
| 34 |
A.R.T. Advisors, LLC |
24,200 |
117,000 |
0.16% |
|
|
| 35 |
DIMENSIONAL FUND ADVISORS LP |
22,977 |
111,000 |
0.15% |
|
|
| 36 |
Bank of New York Mellon Corp |
18,571 |
90,000 |
0.12% |
|
|
| 37 |
GROUP ONE TRADING LLC |
16,896 |
82,000 |
0.11% |
|
|
| 38 |
CITADEL ADVISORS LLC |
16,338 |
79,000 |
0.11% |
|
|
| 39 |
Private Advisor Group, LLC |
14,006 |
75,000 |
0.10% |
|
|
| 40 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
12,700 |
62,000 |
0.09% |
Call |
|
| 41 |
GOLDMAN SACHS GROUP INC |
11,962 |
58,000 |
0.08% |
|
|
| 42 |
CITADEL ADVISORS LLC |
10,800 |
52,000 |
0.07% |
Call |
|
| 43 |
Hartford Financial Management Inc. |
9,800 |
48,000 |
0.07% |
|
|
| 44 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
9,763 |
47,000 |
0.07% |
|
|
| 45 |
Segantii Capital Management Ltd |
5,100 |
25,000 |
0.03% |
|
|
| 46 |
PRELUDE CAPITAL MANAGEMENT, LLC |
5,000 |
24,000 |
0.03% |
|
|
| 47 |
MORGAN STANLEY |
3,941 |
19,000 |
0.03% |
|
|
| 48 |
Tower Research Capital LLC (TRC) |
2,634 |
13,000 |
0.02% |
|
|
| 49 |
BlackRock Investment Management, LLC |
2,643 |
13,000 |
0.02% |
|
|
| 50 |
Creative Planning |
2,142 |
10,000 |
0.01% |
|
|
