| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 2,231,203 | 22,446,000 | 10.76% | ||
| 2 | EVENTIDE ASSET MANAGEMENT, LLC | 2,153,612 | 21,665,000 | 10.39% | ||
| 3 | FRAZIER MANAGEMENT LLC | 1,887,332 | 18,987,000 | 9.10% | ||
| 4 | BlackRock Finance, Inc. | 1,481,207 | 14,902,000 | 7.14% | ||
| 5 | TPG Group Holdings (SBS) Advisors, Inc. | 1,389,863 | 13,982,000 | 6.70% | ||
| 6 | CADIAN CAPITAL MANAGEMENT, LP | 1,357,748 | 13,659,000 | 6.55% | ||
| 7 | SECTORAL ASSET MANAGEMENT INC | 1,279,247 | 12,869,000 | 6.17% | ||
| 8 | HIGHLAND CAPITAL MANAGEMENT LP | 1,065,000 | 10,714,000 | 5.14% | ||
| 9 | MORGAN STANLEY | 885,268 | 8,906,000 | 4.27% | ||
| 10 | MACQUARIE GROUP LTD | 815,799 | 8,207,000 | 3.93% | ||
| 11 | VANGUARD GROUP INC | 806,539 | 8,113,000 | 3.89% | ||
| 12 | PFM Health Sciences, LP | 794,550 | 7,993,000 | 3.83% | ||
| 13 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 640,189 | 6,440,000 | 3.09% | ||
| 14 | BUCKINGHAM CAPITAL MANAGEMENT INC | 386,678 | 3,890,000 | 1.87% | ||
| 15 | Pier Capital, LLC | 366,064 | 3,683,000 | 1.77% | ||
| 16 | J. Goldman & Co LP | 344,129 | 3,462,000 | 1.66% | ||
| 17 | PRUDENTIAL FINANCIAL INC | 341,860 | 3,439,000 | 1.65% | ||
| 18 | STATE STREET CORP | 273,104 | 2,748,000 | 1.32% | ||
| 19 | FMR LLC | 220,000 | 2,213,000 | 1.06% | ||
| 20 | NORTHERN TRUST CORP | 218,846 | 2,202,000 | 1.06% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 146,568 | 1,474,000 | 0.71% | ||
| 22 | D. E. Shaw & Co., Inc. | 143,483 | 1,444,000 | 0.69% | ||
| 23 | LPL Financial LLC | 119,801 | 1,173,000 | 0.56% | ||
| 24 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 108,000 | 1,086,000 | 0.52% | ||
| 25 | MOORE CAPITAL MANAGEMENT, LP | 100,000 | 1,006,000 | 0.48% | ||
| 26 | WELLS FARGO & COMPANY/MN | 86,776 | 873,000 | 0.42% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 86,243 | 868,000 | 0.42% | ||
| 28 | Jefferies Financial Group Inc. | 83,759 | 843,000 | 0.40% | ||
| 29 | CITADEL ADVISORS LLC | 69,909 | 703,000 | 0.34% | ||
| 30 | GOLDMAN SACHS GROUP INC | 65,377 | 658,000 | 0.32% | ||
| 31 | Bank of New York Mellon Corp | 65,305 | 656,000 | 0.31% | ||
| 32 | NBW CAPITAL LLC | 62,030 | 624,000 | 0.30% | ||
| 33 | RAYMOND JAMES & ASSOCIATES | 60,365 | 607,000 | 0.29% | ||
| 34 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 49,128 | 494,000 | 0.24% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 45,036 | 454,000 | 0.22% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 42,496 | 428,000 | 0.21% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 40,800 | 410,000 | 0.20% | Call | |
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,095 | 333,000 | 0.16% | ||
| 39 | DEUTSCHE BANK AG\ | 32,038 | 320,000 | 0.15% | ||
| 40 | TEACHERS ADVISORS, LLC | 29,973 | 302,000 | 0.14% | ||
| 41 | ROYAL BANK OF CANADA | 25,854 | 261,000 | 0.13% | ||
| 42 | GOLDMAN SACHS GROUP INC | 25,000 | 252,000 | 0.12% | Put | |
| 43 | Dynamic Technology Lab Private Ltd | 23,711 | 238,000 | 0.11% | ||
| 44 | Commonwealth Equity Services, Inc | 18,391 | 185,000 | 0.09% | ||
| 45 | RHUMBLINE ADVISERS | 17,679 | 178,000 | 0.09% | ||
| 46 | ProShare Advisors LLC | 17,167 | 173,000 | 0.08% | ||
| 47 | MYCIO WEALTH PARTNERS, LLC | 17,000 | 171,000 | 0.08% | ||
| 48 | Sterling Capital Management LLC | 16,815 | 169,000 | 0.08% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 15,701 | 158,000 | 0.08% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 15,600 | 157,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
