| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,558,920 | 272,329,000 | 29.51% | ||
| 2 | SANDS CAPITAL MANAGEMENT, LLC | 2,138,491 | 163,637,000 | 17.73% | ||
| 3 | FEDERATED HERMES, INC. | 1,364,600 | 104,419,000 | 11.31% | ||
| 4 | EcoR1 Capital, LLC | 578,505 | 44,267,000 | 4.80% | ||
| 5 | RENAISSANCE TECHNOLOGIES LLC | 465,300 | 35,605,000 | 3.86% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 396,721 | 30,357,000 | 3.29% | ||
| 7 | Cormorant Asset Management, LP | 300,000 | 22,918,000 | 2.48% | SH | |
| 8 | ORBIMED ADVISORS LLC | 283,500 | 21,693,000 | 2.35% | ||
| 9 | BAKER BROS. ADVISORS LP | 259,894 | 19,887,000 | 2.15% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 226,405 | 17,325,000 | 1.88% | ||
| 11 | Rock Springs Capital Management LP | 221,500 | 16,949,000 | 1.84% | ||
| 12 | GOLDMAN SACHS GROUP INC | 202,173 | 15,471,000 | 1.68% | ||
| 13 | DEERFIELD MANAGEMENT COMPANY, L.P. | 187,501 | 14,348,000 | 1.55% | ||
| 14 | DEUTSCHE BANK AG\ | 169,395 | 12,961,000 | 1.40% | ||
| 15 | MORGAN STANLEY | 155,767 | 11,919,000 | 1.29% | ||
| 16 | BlackRock Finance, Inc. | 148,300 | 11,349,000 | 1.23% | ||
| 17 | JANE STREET GROUP, LLC | 119,139 | 9,117,000 | 0.99% | ||
| 18 | PEREGRINE CAPITAL MANAGEMENT INC /MN/ | 114,399 | 8,754,000 | 0.95% | ||
| 19 | WILLIAMS JONES & ASSOCIATES LLC | 91,317 | 6,988,000 | 0.76% | ||
| 20 | ASCEND CAPITAL, LLC | 73,964 | 5,661,000 | 0.61% | ||
| 21 | Bain Capital Public Equity Management, LLC | 71,136 | 5,443,000 | 0.59% | ||
| 22 | NORGES BANK | 70,000 | 5,356,000 | 0.58% | ||
| 23 | Alberta Investment Management Corp | 70,000 | 5,356,000 | 0.58% | ||
| 24 | CLOUGH CAPITAL PARTNERS L P | 69,853 | 5,345,000 | 0.58% | ||
| 25 | Employees Retirement System of Texas | 54,000 | 4,132,000 | 0.45% | ||
| 26 | EVENTIDE ASSET MANAGEMENT, LLC | 52,000 | 3,979,000 | 0.43% | ||
| 27 | ALPS ADVISORS INC | 45,868 | 3,510,000 | 0.38% | ||
| 28 | GRATICULE ASIA MACRO ADVISORS LLC | 41,818 | 3,200,000 | 0.35% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 41,458 | 3,172,000 | 0.34% | ||
| 30 | DAFNA Capital Management LLC | 38,609 | 2,954,000 | 0.32% | ||
| 31 | Bank of New York Mellon Corp | 38,093 | 2,915,000 | 0.32% | ||
| 32 | Dorsey Wright & Associates | 33,569 | 2,569,000 | 0.28% | ||
| 33 | CREDIT SUISSE AG/ | 28,000 | 2,143,000 | 0.23% | ||
| 34 | US BANCORP \DE\ | 27,731 | 2,122,000 | 0.23% | ||
| 35 | Weiss Multi-Strategy Advisers LLC | 20,000 | 1,530,000 | 0.17% | ||
| 36 | Hudson Bay Capital Management LP | 20,000 | 1,530,000 | 0.17% | ||
| 37 | Tekla Capital Management LLC | 19,000 | 1,454,000 | 0.16% | ||
| 38 | NORTHERN TRUST CORP | 18,480 | 1,414,000 | 0.15% | ||
| 39 | Atika Capital Management LLC | 18,000 | 1,377,000 | 0.15% | ||
| 40 | ALLIANCEBERNSTEIN L.P. | 17,410 | 1,332,000 | 0.14% | ||
| 41 | HBK INVESTMENTS L P | 17,300 | 1,324,000 | 0.14% | ||
| 42 | MARSHALL WACE NORTH AMERICA, L.P. | 17,011 | 1,310,000 | 0.14% | ||
| 43 | FNY PARTNERS FUND LP | 14,500 | 1,109,000 | 0.12% | ||
| 44 | P.A.W. CAPITAL CORP | 12,500 | 957,000 | 0.10% | ||
| 45 | Airain ltd | 12,204 | 934,000 | 0.10% | ||
| 46 | CITADEL ADVISORS LLC | 11,155 | 854,000 | 0.09% | ||
| 47 | DRIEHAUS CAPITAL MANAGEMENT LLC | 10,803 | 827,000 | 0.09% | ||
| 48 | Freedom Investment Management, Inc. | 10,346 | 792,000 | 0.09% | ||
| 49 | MACQUARIE GROUP LTD | 9,238 | 707,000 | 0.08% | ||
| 50 | Cubist Systematic Strategies, LLC | 9,200 | 704,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
