| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 9,854,255 | 290,503,000 | 30.97% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 3,707,235 | 109,290,000 | 11.65% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,772,153 | 52,243,000 | 5.57% | ||
| 4 | HealthCor Management, L.P. | 1,400,000 | 41,272,000 | 4.40% | ||
| 5 | FMR LLC | 1,325,194 | 39,067,000 | 4.17% | ||
| 6 | ALLIANCEBERNSTEIN L.P. | 1,277,305 | 37,655,000 | 4.01% | ||
| 7 | PERCEPTIVE ADVISORS LLC | 1,230,070 | 36,262,000 | 3.87% | ||
| 8 | ORBIMED ADVISORS LLC | 847,800 | 24,993,000 | 2.66% | ||
| 9 | VANGUARD GROUP INC | 814,889 | 24,023,000 | 2.56% | ||
| 10 | FRANKLIN RESOURCES INC | 800,300 | 23,593,000 | 2.52% | ||
| 11 | STATE STREET CORP | 719,960 | 21,230,000 | 2.26% | ||
| 12 | RA CAPITAL MANAGEMENT, L.P. | 700,000 | 20,636,000 | 2.20% | ||
| 13 | ORACLE INVESTMENT MANAGEMENT INC | 633,752 | 18,683,009 | 1.99% | ||
| 14 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 615,000 | 18,130,000 | 1.93% | ||
| 15 | BB BIOTECH AG | 604,582 | 17,823,000 | 1.90% | ||
| 16 | BlackRock Fund Advisors | 576,261 | 16,988,000 | 1.81% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 494,416 | 14,575,000 | 1.55% | ||
| 18 | APEX CAPITAL, LLC | 325,000 | 9,581,000 | 1.02% | ||
| 19 | Cormorant Asset Management, LP | 300,000 | 8,844,000 | 0.94% | ||
| 20 | NORTHERN TRUST CORP | 220,087 | 6,488,000 | 0.69% | ||
| 21 | Visium Asset Management, LP | 206,323 | 6,083,000 | 0.65% | ||
| 22 | AMERIPRISE FINANCIAL INC | 196,894 | 5,805,000 | 0.62% | ||
| 23 | Invesco Ltd. | 195,566 | 5,765,000 | 0.61% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 191,334 | 5,641,000 | 0.60% | ||
| 25 | LORD, ABBETT & CO. LLC | 157,857 | 4,654,000 | 0.50% | ||
| 26 | WELLS FARGO & COMPANY/MN | 157,598 | 4,646,000 | 0.50% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 156,600 | 4,617,000 | 0.49% | Put | |
| 28 | PUTNAM INVESTMENTS LLC | 133,000 | 3,921,000 | 0.42% | ||
| 29 | Rock Springs Capital Management LP | 129,500 | 3,818,000 | 0.41% | ||
| 30 | AQR CAPITAL MANAGEMENT LLC | 118,556 | 3,495,000 | 0.37% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 105,773 | 3,118,000 | 0.33% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 104,226 | 3,073,000 | 0.33% | ||
| 33 | DEUTSCHE BANK AG\ | 102,483 | 3,019,000 | 0.32% | ||
| 34 | SABBY MANAGEMENT, LLC | 98,500 | 2,904,000 | 0.31% | ||
| 35 | CITADEL ADVISORS LLC | 90,410 | 2,665,000 | 0.28% | ||
| 36 | OXFORD ASSET MANAGEMENT LLP | 89,897 | 2,650,000 | 0.28% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 75,200 | 2,217,000 | 0.24% | Call | |
| 38 | COLUMBUS CIRCLE INVESTORS | 71,678 | 2,113,000 | 0.23% | ||
| 39 | Bank of New York Mellon Corp | 68,552 | 2,020,000 | 0.22% | ||
| 40 | MASON STREET ADVISORS, LLC | 68,400 | 2,016,000 | 0.21% | ||
| 41 | TD ASSET MANAGEMENT INC | 53,206 | 1,569,000 | 0.17% | ||
| 42 | Iguana Healthcare Management, LLC | 50,000 | 1,474,000 | 0.16% | ||
| 43 | PDT Partners, LLC | 42,618 | 1,256,000 | 0.13% | ||
| 44 | SUFFOLK CAPITAL MANAGEMENT LLC | 42,500 | 1,253,000 | 0.13% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 41,696 | 1,230,000 | 0.13% | ||
| 46 | BlackRock Investment Management, LLC | 40,939 | 1,207,000 | 0.13% | ||
| 47 | MACQUARIE GROUP LTD | 40,680 | 1,199,000 | 0.13% | ||
| 48 | ArrowMark Colorado Holdings LLC | 39,258 | 1,157,000 | 0.12% | ||
| 49 | BANK OF AMERICA CORP /DE/ | 38,975 | 1,149,000 | 0.12% | ||
| 50 | D. E. Shaw & Co., Inc. | 37,040 | 1,092,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
