| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 9,854,255 | 306,566,000 | 30.55% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 4,359,831 | 135,635,000 | 13.52% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,474,339 | 76,977,000 | 7.67% | ||
| 4 | HealthCor Management, L.P. | 1,475,000 | 45,887,000 | 4.57% | ||
| 5 | ALLIANCEBERNSTEIN L.P. | 1,377,670 | 42,859,000 | 4.27% | ||
| 6 | FMR LLC | 1,225,894 | 38,138,000 | 3.80% | ||
| 7 | VANGUARD GROUP INC | 828,226 | 25,766,000 | 2.57% | ||
| 8 | FRANKLIN RESOURCES INC | 800,300 | 24,897,000 | 2.48% | ||
| 9 | STATE STREET CORP | 746,747 | 23,230,000 | 2.32% | ||
| 10 | BB BIOTECH AG | 704,582 | 21,920,000 | 2.18% | ||
| 11 | PERCEPTIVE ADVISORS LLC | 636,956 | 19,816,000 | 1.97% | ||
| 12 | ORACLE INVESTMENT MANAGEMENT INC | 633,752 | 19,716,025 | 1.96% | ||
| 13 | BlackRock Fund Advisors | 629,667 | 19,589,000 | 1.95% | ||
| 14 | GOLDMAN SACHS GROUP INC | 592,119 | 18,421,000 | 1.84% | ||
| 15 | APEX CAPITAL, LLC | 340,400 | 10,590,000 | 1.06% | ||
| 16 | PUTNAM INVESTMENTS LLC | 333,964 | 10,390,000 | 1.04% | ||
| 17 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 9,333,000 | 0.93% | ||
| 18 | Cormorant Asset Management, LP | 300,000 | 9,333,000 | 0.93% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 244,122 | 7,595,000 | 0.76% | ||
| 20 | AMERIPRISE FINANCIAL INC | 223,874 | 6,965,000 | 0.69% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 207,636 | 6,460,000 | 0.64% | ||
| 22 | NORTHERN TRUST CORP | 207,283 | 6,448,000 | 0.64% | ||
| 23 | WELLS FARGO & COMPANY/MN | 201,353 | 6,265,000 | 0.62% | ||
| 24 | Invesco Ltd. | 196,497 | 6,113,000 | 0.61% | ||
| 25 | FRED ALGER MANAGEMENT, LLC | 176,800 | 5,500,000 | 0.55% | ||
| 26 | Rock Springs Capital Management LP | 165,000 | 5,133,000 | 0.51% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 152,100 | 4,732,000 | 0.47% | Put | |
| 28 | LORD, ABBETT & CO. LLC | 149,124 | 4,639,000 | 0.46% | ||
| 29 | Numeric Investors LLC | 148,332 | 4,615,000 | 0.46% | ||
| 30 | DEUTSCHE BANK AG\ | 148,334 | 4,612,000 | 0.46% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 134,077 | 4,171,000 | 0.42% | ||
| 32 | COLUMBUS CIRCLE INVESTORS | 123,697 | 3,848,000 | 0.38% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 111,207 | 3,460,000 | 0.34% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 110,697 | 3,443,000 | 0.34% | ||
| 35 | Bank of New York Mellon Corp | 109,367 | 3,403,000 | 0.34% | ||
| 36 | TEACHERS ADVISORS, LLC | 107,968 | 3,359,000 | 0.33% | ||
| 37 | PERCEPTIVE ADVISORS LLC | 100,000 | 3,111,000 | 0.31% | Put | |
| 38 | BARCLAYS PLC | 90,000 | 2,790,000 | 0.28% | Call | |
| 39 | SUFFOLK CAPITAL MANAGEMENT LLC | 79,033 | 2,459,000 | 0.25% | ||
| 40 | MASON STREET ADVISORS, LLC | 68,400 | 2,128,000 | 0.21% | ||
| 41 | Alyeska Investment Group, L.P. | 65,928 | 2,051,000 | 0.20% | ||
| 42 | CITADEL ADVISORS LLC | 63,118 | 1,963,000 | 0.20% | ||
| 43 | AQR CAPITAL MANAGEMENT LLC | 62,556 | 1,946,000 | 0.19% | ||
| 44 | TD ASSET MANAGEMENT INC | 57,806 | 1,798,000 | 0.18% | ||
| 45 | MACQUARIE GROUP LTD | 57,656 | 1,794,000 | 0.18% | ||
| 46 | Rhenman & Partners Asset Management AB | 55,000 | 1,711,000 | 0.17% | ||
| 47 | BlackRock Investment Management, LLC | 52,537 | 1,634,000 | 0.16% | ||
| 48 | Jefferies Group LLC | 50,000 | 1,556,000 | 0.16% | Put | |
| 49 | Iguana Healthcare Management, LLC | 50,000 | 1,556,000 | 0.16% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 47,716 | 1,485,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
