| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 10,275,113 | 452,413,000 | 21.65% | ||
| 2 | FMR LLC | 5,565,557 | 245,051,000 | 11.73% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,384,104 | 193,032,000 | 9.24% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 4,204,477 | 185,122,000 | 8.86% | ||
| 5 | VANGUARD GROUP INC | 1,996,837 | 87,921,000 | 4.21% | ||
| 6 | ORBIMED ADVISORS LLC | 1,912,000 | 84,185,000 | 4.03% | ||
| 7 | Point72 Asset Management, L.P. | 1,351,785 | 59,519,000 | 2.85% | ||
| 8 | BlackRock Fund Advisors | 1,293,906 | 56,971,000 | 2.73% | ||
| 9 | BB BIOTECH AG | 1,229,582 | 54,138,000 | 2.59% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 1,098,659 | 48,374,000 | 2.31% | ||
| 11 | JENNISON ASSOCIATES LLC | 949,490 | 41,806,000 | 2.00% | ||
| 12 | STATE STREET CORP | 893,749 | 39,349,000 | 1.88% | ||
| 13 | ALLIANCEBERNSTEIN L.P. | 875,973 | 38,569,000 | 1.85% | ||
| 14 | PUTNAM INVESTMENTS LLC | 723,731 | 31,865,000 | 1.52% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 698,326 | 30,747,000 | 1.47% | ||
| 16 | SECTORAL ASSET MANAGEMENT INC | 689,869 | 30,375,000 | 1.45% | ||
| 17 | ORACLE INVESTMENT MANAGEMENT INC | 640,966 | 28,222,000 | 1.35% | ||
| 18 | FRANKLIN RESOURCES INC | 494,900 | 21,790,000 | 1.04% | ||
| 19 | BLACKROCK ADVISORS LLC | 411,096 | 18,101,000 | 0.87% | ||
| 20 | Rock Springs Capital Management LP | 379,500 | 16,709,000 | 0.80% | ||
| 21 | DEUTSCHE BANK AG\ | 337,173 | 14,843,000 | 0.71% | ||
| 22 | FEDERATED HERMES, INC. | 322,500 | 14,200,000 | 0.68% | ||
| 23 | MACQUARIE GROUP LTD | 320,168 | 14,097,000 | 0.67% | ||
| 24 | CITIGROUP INC | 315,439 | 13,888,000 | 0.66% | ||
| 25 | NORTHERN TRUST CORP | 305,301 | 13,443,000 | 0.64% | ||
| 26 | Cormorant Asset Management, LP | 291,250 | 12,824,000 | 0.61% | ||
| 27 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 285,107 | 12,553,000 | 0.60% | ||
| 28 | RUSSELL FRANK CO/ | 282,162 | 12,424,000 | 0.59% | ||
| 29 | SUFFOLK CAPITAL MANAGEMENT LLC | 252,045 | 11,098,000 | 0.53% | ||
| 30 | NORGES BANK | 233,625 | 10,287,000 | 0.49% | ||
| 31 | Polar Capital LLP | 200,000 | 8,806,000 | 0.42% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 197,043 | 8,675,000 | 0.42% | ||
| 33 | EVENTIDE ASSET MANAGEMENT, LLC | 180,000 | 7,925,000 | 0.38% | ||
| 34 | Candriam S.C.A. | 175,000 | 7,664,000 | 0.37% | ||
| 35 | BlackRock Group LTD | 162,499 | 7,154,000 | 0.34% | ||
| 36 | Avoro Capital Advisors LLC | 150,000 | 6,605,000 | 0.32% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 135,900 | 5,984,000 | 0.29% | Put | |
| 38 | BlackRock Investment Management, LLC | 126,552 | 5,572,000 | 0.27% | ||
| 39 | WELLS FARGO & COMPANY/MN | 126,508 | 5,570,000 | 0.27% | ||
| 40 | Bank of New York Mellon Corp | 123,568 | 5,440,000 | 0.26% | ||
| 41 | AMERIPRISE FINANCIAL INC | 117,587 | 5,180,000 | 0.25% | ||
| 42 | FRED ALGER MANAGEMENT, LLC | 114,017 | 5,020,000 | 0.24% | ||
| 43 | TD ASSET MANAGEMENT INC | 100,706 | 4,434,000 | 0.21% | ||
| 44 | PointState Capital LP | 100,000 | 4,403,000 | 0.21% | ||
| 45 | UBS Group AG | 100,000 | 4,403,000 | 0.21% | Call | |
| 46 | EverPoint Asset Management, LLC | 100,000 | 4,403,000 | 0.21% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 91,100 | 4,011,000 | 0.19% | Call | |
| 48 | BNP Paribas Asset Management Holding S.A. | 86,523 | 3,810,000 | 0.18% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 86,293 | 3,800,000 | 0.18% | ||
| 50 | GUGGENHEIM CAPITAL LLC | 85,140 | 3,749,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
