| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 9,854,255 | 565,634,000 | 23.25% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 4,264,704 | 244,795,000 | 10.06% | ||
| 3 | FMR LLC | 3,985,015 | 228,740,000 | 9.40% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,538,524 | 203,111,000 | 8.35% | ||
| 5 | ORBIMED ADVISORS LLC | 2,057,700 | 118,112,000 | 4.86% | ||
| 6 | VANGUARD GROUP INC | 1,582,465 | 90,834,000 | 3.73% | ||
| 7 | ALLIANCEBERNSTEIN L.P. | 1,110,951 | 63,769,000 | 2.62% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 978,359 | 56,158,000 | 2.31% | ||
| 9 | HealthCor Management, L.P. | 925,000 | 53,095,000 | 2.18% | ||
| 10 | BB BIOTECH AG | 854,582 | 49,053,000 | 2.02% | ||
| 11 | Point72 Asset Management, L.P. | 814,900 | 46,775,000 | 1.92% | ||
| 12 | BlackRock Fund Advisors | 802,525 | 46,065,000 | 1.89% | ||
| 13 | LORD, ABBETT & CO. LLC | 713,404 | 40,949,000 | 1.68% | ||
| 14 | STATE STREET CORP | 701,524 | 40,267,000 | 1.66% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 605,628 | 34,763,000 | 1.43% | ||
| 16 | FRANKLIN RESOURCES INC | 570,100 | 32,724,000 | 1.35% | ||
| 17 | ORACLE INVESTMENT MANAGEMENT INC | 556,379 | 31,936,000 | 1.31% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 528,400 | 30,330,000 | 1.25% | Put | |
| 19 | HealthCor Management, L.P. | 500,000 | 28,700,000 | 1.18% | Put | |
| 20 | MILLENNIUM MANAGEMENT LLC | 488,034 | 28,013,000 | 1.15% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 364,200 | 20,905,000 | 0.86% | Call | |
| 22 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 346,057 | 19,863,671 | 0.82% | ||
| 23 | PUTNAM INVESTMENTS LLC | 333,361 | 19,135,000 | 0.79% | ||
| 24 | DEUTSCHE BANK AG\ | 294,437 | 16,898,000 | 0.69% | ||
| 25 | D. E. Shaw & Co., Inc. | 286,035 | 16,419,000 | 0.68% | ||
| 26 | NORTHERN TRUST CORP | 260,649 | 14,961,000 | 0.62% | ||
| 27 | JENNISON ASSOCIATES LLC | 250,247 | 14,364,000 | 0.59% | ||
| 28 | Rock Springs Capital Management LP | 210,000 | 12,054,000 | 0.50% | ||
| 29 | EverPoint Asset Management, LLC | 200,000 | 11,480,000 | 0.47% | ||
| 30 | CITIGROUP INC | 194,270 | 11,151,000 | 0.46% | ||
| 31 | Cormorant Asset Management, LP | 191,250 | 10,978,000 | 0.45% | ||
| 32 | LOOMIS SAYLES & CO L P | 180,946 | 10,386,000 | 0.43% | ||
| 33 | AMERIPRISE FINANCIAL INC | 172,268 | 9,889,000 | 0.41% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 155,192 | 8,908,000 | 0.37% | ||
| 35 | WELLS FARGO & COMPANY/MN | 153,861 | 8,831,000 | 0.36% | ||
| 36 | RENAISSANCE TECHNOLOGIES LLC | 148,704 | 8,536,000 | 0.35% | ||
| 37 | Candriam S.C.A. | 140,000 | 8,038,000 | 0.33% | ||
| 38 | Bank of New York Mellon Corp | 139,105 | 7,985,000 | 0.33% | ||
| 39 | MACQUARIE GROUP LTD | 131,483 | 7,547,000 | 0.31% | ||
| 40 | AMUNDI ASSET MANAGEMENT US, INC. | 129,230 | 7,418,000 | 0.30% | ||
| 41 | TEACHERS ADVISORS, LLC | 128,206 | 7,359,000 | 0.30% | ||
| 42 | TWO SIGMA INVESTMENTS, LP | 123,129 | 7,068,000 | 0.29% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 112,520 | 6,459,000 | 0.27% | ||
| 44 | FRED ALGER MANAGEMENT, LLC | 109,988 | 6,313,000 | 0.26% | ||
| 45 | GUGGENHEIM CAPITAL LLC | 109,450 | 6,282,000 | 0.26% | ||
| 46 | EVENTIDE ASSET MANAGEMENT, LLC | 87,700 | 5,034,000 | 0.21% | ||
| 47 | TD ASSET MANAGEMENT INC | 86,606 | 4,971,000 | 0.20% | ||
| 48 | OXFORD ASSET MANAGEMENT LLP | 79,851 | 4,583,000 | 0.19% | ||
| 49 | Informed Momentum Co LLC | 68,548 | 3,935,000 | 0.16% | ||
| 50 | Invesco Ltd. | 68,223 | 3,916,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
