| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 9,854,255 | 265,277,000 | 29.10% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 4,789,067 | 128,921,000 | 14.14% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,446,139 | 65,850,000 | 7.22% | ||
| 4 | ALLIANCEBERNSTEIN L.P. | 1,438,486 | 38,724,000 | 4.25% | ||
| 5 | FMR LLC | 1,225,894 | 33,001,000 | 3.62% | ||
| 6 | HealthCor Management, L.P. | 1,198,795 | 32,272,000 | 3.54% | ||
| 7 | GOLDMAN SACHS GROUP INC | 879,783 | 23,683,000 | 2.60% | ||
| 8 | VANGUARD GROUP INC | 874,014 | 23,528,000 | 2.58% | ||
| 9 | STATE STREET CORP | 776,863 | 20,914,000 | 2.29% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 708,284 | 19,067,000 | 2.09% | ||
| 11 | BB BIOTECH AG | 704,582 | 18,967,000 | 2.08% | ||
| 12 | FRANKLIN RESOURCES INC | 691,200 | 18,607,000 | 2.04% | ||
| 13 | BlackRock Fund Advisors | 633,229 | 17,047,000 | 1.87% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 585,332 | 15,757,000 | 1.73% | ||
| 15 | ORACLE INVESTMENT MANAGEMENT INC | 556,379 | 14,978,000 | 1.64% | ||
| 16 | LOOMIS SAYLES & CO L P | 474,067 | 12,761,000 | 1.40% | ||
| 17 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 374,274 | 10,075,000 | 1.11% | ||
| 18 | PUTNAM INVESTMENTS LLC | 334,655 | 9,008,000 | 0.99% | ||
| 19 | Cormorant Asset Management, LP | 300,000 | 8,076,000 | 0.89% | ||
| 20 | CLOUGH CAPITAL PARTNERS L P | 258,100 | 6,948,000 | 0.76% | ||
| 21 | NORTHERN TRUST CORP | 256,849 | 6,914,000 | 0.76% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 230,699 | 6,210,000 | 0.68% | ||
| 23 | AQR CAPITAL MANAGEMENT LLC | 206,445 | 5,557,000 | 0.61% | ||
| 24 | AMERIPRISE FINANCIAL INC | 183,744 | 4,946,000 | 0.54% | ||
| 25 | WELLS FARGO & COMPANY/MN | 180,893 | 4,870,000 | 0.53% | ||
| 26 | Rock Springs Capital Management LP | 177,500 | 4,778,000 | 0.52% | ||
| 27 | Point72 Asset Management, L.P. | 174,008 | 4,684,000 | 0.51% | ||
| 28 | LORD, ABBETT & CO. LLC | 165,242 | 4,448,000 | 0.49% | ||
| 29 | FRED ALGER MANAGEMENT, LLC | 152,477 | 4,105,000 | 0.45% | ||
| 30 | PointState Capital LP | 150,000 | 4,038,000 | 0.44% | ||
| 31 | COLUMBUS CIRCLE INVESTORS | 147,200 | 3,963,000 | 0.43% | ||
| 32 | TEACHERS ADVISORS, LLC | 125,968 | 3,391,000 | 0.37% | ||
| 33 | DEUTSCHE BANK AG\ | 123,838 | 3,332,000 | 0.37% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 120,819 | 3,252,000 | 0.36% | ||
| 35 | BLUE ARROW CAPITAL MANAGEMENT LLC | 120,000 | 3,230,000 | 0.35% | ||
| 36 | GEODE CAPITAL MANAGEMENT, LLC | 116,452 | 3,134,000 | 0.34% | ||
| 37 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 113,000 | 3,042,000 | 0.33% | ||
| 38 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 113,000 | 3,042,000 | 0.33% | ||
| 39 | GUGGENHEIM CAPITAL LLC | 103,140 | 2,777,000 | 0.30% | ||
| 40 | CREDIT SUISSE AG/ | 98,685 | 2,656,000 | 0.29% | ||
| 41 | Bank of New York Mellon Corp | 95,113 | 2,560,000 | 0.28% | ||
| 42 | GOLDMAN SACHS GROUP INC | 80,000 | 2,154,000 | 0.24% | Call | |
| 43 | GOLDMAN SACHS GROUP INC | 80,000 | 2,154,000 | 0.24% | Put | |
| 44 | MASON STREET ADVISORS, LLC | 68,400 | 1,841,000 | 0.20% | ||
| 45 | OXFORD ASSET MANAGEMENT LLP | 68,351 | 1,830,000 | 0.20% | ||
| 46 | SUFFOLK CAPITAL MANAGEMENT LLC | 63,133 | 1,700,000 | 0.19% | ||
| 47 | Alyeska Investment Group, L.P. | 62,950 | 1,695,000 | 0.19% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,800 | 1,529,000 | 0.17% | Put | |
| 49 | TD ASSET MANAGEMENT INC | 56,806 | 1,529,000 | 0.17% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 55,119 | 1,484,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
