| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 8,854,255 | 355,056,000 | 20.43% | ||
| 2 | FMR LLC | 6,003,949 | 240,758,000 | 13.86% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,514,838 | 140,945,000 | 8.11% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 3,215,553 | 128,943,000 | 7.42% | ||
| 5 | VANGUARD GROUP INC | 1,884,932 | 75,585,000 | 4.35% | ||
| 6 | ORBIMED ADVISORS LLC | 1,735,200 | 69,582,000 | 4.00% | ||
| 7 | BB BIOTECH AG | 1,154,582 | 46,299,000 | 2.66% | ||
| 8 | Point72 Asset Management, L.P. | 1,111,700 | 44,579,000 | 2.57% | ||
| 9 | ALLIANCEBERNSTEIN L.P. | 1,034,809 | 41,496,000 | 2.39% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 981,759 | 39,368,000 | 2.27% | ||
| 11 | PUTNAM INVESTMENTS LLC | 830,793 | 33,315,000 | 1.92% | ||
| 12 | STATE STREET CORP | 817,067 | 32,763,000 | 1.89% | ||
| 13 | BlackRock Fund Advisors | 792,582 | 31,783,000 | 1.83% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 696,745 | 27,939,000 | 1.61% | ||
| 15 | ALPS ADVISORS INC | 62,611 | 25,107,000 | 1.44% | ||
| 16 | LORD, ABBETT & CO. LLC | 533,687 | 21,401,000 | 1.23% | ||
| 17 | FRANKLIN RESOURCES INC | 504,100 | 20,214,000 | 1.16% | ||
| 18 | ORACLE INVESTMENT MANAGEMENT INC | 494,250 | 19,819,000 | 1.14% | ||
| 19 | Polar Capital LLP | 400,000 | 16,040,000 | 0.92% | ||
| 20 | CITIGROUP INC | 393,636 | 15,785,000 | 0.91% | ||
| 21 | BLACKROCK ADVISORS LLC | 391,951 | 15,717,000 | 0.90% | ||
| 22 | JENNISON ASSOCIATES LLC | 364,420 | 14,613,000 | 0.84% | ||
| 23 | EverPoint Asset Management, LLC | 360,000 | 14,436,000 | 0.83% | ||
| 24 | DEUTSCHE BANK AG\ | 352,461 | 14,131,000 | 0.81% | ||
| 25 | CITADEL ADVISORS LLC | 324,067 | 12,995,000 | 0.75% | ||
| 26 | Cormorant Asset Management, LP | 291,250 | 11,679,000 | 0.67% | ||
| 27 | NORTHERN TRUST CORP | 285,790 | 11,461,000 | 0.66% | ||
| 28 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 283,503 | 11,368,000 | 0.65% | ||
| 29 | MACQUARIE GROUP LTD | 258,176 | 10,353,000 | 0.60% | ||
| 30 | Rock Springs Capital Management LP | 226,000 | 9,063,000 | 0.52% | ||
| 31 | LOOMIS SAYLES & CO L P | 217,809 | 8,735,000 | 0.50% | ||
| 32 | MILLENNIUM MANAGEMENT LLC | 197,644 | 7,926,000 | 0.46% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 179,175 | 7,184,000 | 0.41% | ||
| 34 | D. E. Shaw & Co., Inc. | 177,238 | 7,107,000 | 0.41% | ||
| 35 | AMERIPRISE FINANCIAL INC | 172,540 | 6,920,000 | 0.40% | ||
| 36 | EVENTIDE ASSET MANAGEMENT, LLC | 168,000 | 6,737,000 | 0.39% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 155,600 | 6,240,000 | 0.36% | Call | |
| 38 | BlackRock Group LTD | 151,203 | 6,064,000 | 0.35% | ||
| 39 | WELLS FARGO & COMPANY/MN | 148,757 | 5,965,000 | 0.34% | ||
| 40 | GUGGENHEIM CAPITAL LLC | 147,393 | 5,910,000 | 0.34% | ||
| 41 | Bank of New York Mellon Corp | 137,166 | 5,501,000 | 0.32% | ||
| 42 | NORGES BANK | 135,736 | 5,443,000 | 0.31% | ||
| 43 | TEACHERS ADVISORS, LLC | 132,072 | 5,296,000 | 0.30% | ||
| 44 | COLUMBUS CIRCLE INVESTORS | 129,009 | 5,173,000 | 0.30% | ||
| 45 | AMUNDI ASSET MANAGEMENT US, INC. | 119,231 | 4,781,000 | 0.28% | ||
| 46 | SPHERA FUNDS MANAGEMENT LTD. | 117,500 | 4,712,000 | 0.27% | ||
| 47 | BlackRock Investment Management, LLC | 116,365 | 4,666,000 | 0.27% | ||
| 48 | TIAA CREF INVESTMENT MANAGEMENT LLC | 105,229 | 4,220,000 | 0.24% | ||
| 49 | FRED ALGER MANAGEMENT, LLC | 97,443 | 3,907,000 | 0.22% | ||
| 50 | BARCLAYS PLC | 92,000 | 3,680,000 | 0.21% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
