| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 10,275,113 | 1,029,977,000 | 18.95% | ||
| 2 | FMR LLC | 7,704,856 | 772,335,000 | 14.21% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,584,279 | 559,768,000 | 10.30% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 2,931,027 | 293,806,000 | 5.40% | ||
| 5 | FRANKLIN RESOURCES INC | 2,507,993 | 251,405,000 | 4.62% | ||
| 6 | VANGUARD GROUP INC | 2,496,904 | 250,289,000 | 4.60% | ||
| 7 | BlackRock Fund Advisors | 1,533,499 | 153,718,000 | 2.83% | ||
| 8 | STATE STREET CORP | 1,173,425 | 117,620,000 | 2.16% | ||
| 9 | ORACLE INVESTMENT MANAGEMENT INC | 1,154,322 | 115,709,000 | 2.13% | ||
| 10 | BB BIOTECH AG | 974,582 | 97,692,000 | 1.80% | ||
| 11 | FEDERATED HERMES, INC. | 864,900 | 86,698,000 | 1.59% | ||
| 12 | LORD, ABBETT & CO. LLC | 836,070 | 83,808,000 | 1.54% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 770,929 | 77,278,000 | 1.42% | ||
| 14 | ALLIANCEBERNSTEIN L.P. | 745,918 | 74,771,000 | 1.38% | ||
| 15 | JANUS HENDERSON INVESTORS US LLC | 709,924 | 71,163,000 | 1.31% | ||
| 16 | PERCEPTIVE ADVISORS LLC | 682,415 | 68,405,000 | 1.26% | ||
| 17 | Rock Springs Capital Management LP | 626,500 | 62,800,000 | 1.16% | ||
| 18 | Bank of New York Mellon Corp | 493,701 | 49,490,000 | 0.91% | ||
| 19 | DEUTSCHE BANK AG\ | 447,004 | 44,805,000 | 0.82% | ||
| 20 | VIKING GLOBAL INVESTORS LP | 422,888 | 42,390,000 | 0.78% | ||
| 21 | NORTHERN TRUST CORP | 343,935 | 34,476,000 | 0.63% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 319,300 | 32,007,000 | 0.59% | Put | |
| 23 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 304,807 | 30,554,000 | 0.56% | ||
| 24 | EverPoint Asset Management, LLC | 300,000 | 30,072,000 | 0.55% | Call | |
| 25 | PICTET ASSET MANAGEMENT LTD | 297,628 | 29,834,000 | 0.55% | ||
| 26 | NORGES BANK | 304,121 | 29,116,000 | 0.54% | ||
| 27 | MACQUARIE GROUP LTD | 287,680 | 28,837,000 | 0.53% | ||
| 28 | Avoro Capital Advisors LLC | 277,703 | 27,837,000 | 0.51% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 259,607 | 26,023,000 | 0.48% | ||
| 30 | DEERFIELD MANAGEMENT COMPANY, L.P. | 242,300 | 24,288,000 | 0.45% | ||
| 31 | JENNISON ASSOCIATES LLC | 239,196 | 23,977,000 | 0.44% | ||
| 32 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 231,239 | 23,179,000 | 0.43% | ||
| 33 | 1832 Asset Management L.P. | 232,500 | 22,566,000 | 0.42% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 209,800 | 21,030,000 | 0.39% | Call | |
| 35 | RENAISSANCE TECHNOLOGIES LLC | 202,900 | 20,339,000 | 0.37% | ||
| 36 | BARCLAYS PLC | 187,300 | 18,775,000 | 0.35% | Put | |
| 37 | CITADEL ADVISORS LLC | 181,514 | 18,194,000 | 0.33% | ||
| 38 | Polar Capital LLP | 176,618 | 17,704,000 | 0.33% | ||
| 39 | Point72 Asset Management, L.P. | 175,200 | 17,562,000 | 0.32% | ||
| 40 | AMUNDI ASSET MANAGEMENT US, INC. | 172,221 | 17,263,000 | 0.32% | ||
| 41 | GOLDMAN SACHS GROUP INC | 154,527 | 15,490,000 | 0.28% | ||
| 42 | EMERALD ACQUISITION LTD. | 153,334 | 15,370,000 | 0.28% | ||
| 43 | EverPoint Asset Management, LLC | 150,000 | 15,036,000 | 0.28% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 146,990 | 14,735,000 | 0.27% | ||
| 45 | OppenheimerFunds, Inc. | 143,660 | 14,400,000 | 0.26% | ||
| 46 | GOLDMAN SACHS GROUP INC | 141,900 | 14,224,000 | 0.26% | Call | |
| 47 | Alyeska Investment Group, L.P. | 139,616 | 13,995,000 | 0.26% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 128,279 | 12,858,000 | 0.24% | ||
| 49 | AMERIPRISE FINANCIAL INC | 127,021 | 12,734,000 | 0.23% | ||
| 50 | TD ASSET MANAGEMENT INC | 125,303 | 12,560,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
