| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 9,854,255 | 366,480,000 | 27.34% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 5,022,323 | 186,780,000 | 13.94% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,530,539 | 94,111,000 | 7.02% | ||
| 4 | ALLIANCEBERNSTEIN L.P. | 1,346,499 | 50,076,000 | 3.74% | ||
| 5 | ORBIMED ADVISORS LLC | 1,330,000 | 49,463,000 | 3.69% | ||
| 6 | FMR LLC | 1,225,894 | 45,591,000 | 3.40% | ||
| 7 | HealthCor Management, L.P. | 1,050,000 | 39,050,000 | 2.91% | ||
| 8 | VANGUARD GROUP INC | 976,145 | 36,303,000 | 2.71% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 883,359 | 32,852,000 | 2.45% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 777,073 | 28,899,000 | 2.16% | ||
| 11 | STATE STREET CORP | 732,377 | 27,238,000 | 2.03% | ||
| 12 | BlackRock Fund Advisors | 722,474 | 26,869,000 | 2.00% | ||
| 13 | BB BIOTECH AG | 704,582 | 26,203,000 | 1.96% | ||
| 14 | FRANKLIN RESOURCES INC | 632,600 | 23,526,000 | 1.76% | ||
| 15 | Point72 Asset Management, L.P. | 616,409 | 22,924,000 | 1.71% | ||
| 16 | GOLDMAN SACHS GROUP INC | 557,191 | 20,722,000 | 1.55% | ||
| 17 | ORACLE INVESTMENT MANAGEMENT INC | 556,379 | 20,692,000 | 1.54% | ||
| 18 | LOOMIS SAYLES & CO L P | 451,183 | 16,779,000 | 1.25% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 336,128 | 12,501,000 | 0.93% | ||
| 20 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 335,466 | 12,475,980 | 0.93% | ||
| 21 | PUTNAM INVESTMENTS LLC | 334,543 | 12,442,000 | 0.93% | ||
| 22 | DEUTSCHE BANK AG\ | 330,355 | 12,284,000 | 0.92% | ||
| 23 | Cormorant Asset Management, LP | 300,000 | 11,157,000 | 0.83% | ||
| 24 | CITIGROUP INC | 288,723 | 10,738,000 | 0.80% | ||
| 25 | NORTHERN TRUST CORP | 253,400 | 9,424,000 | 0.70% | ||
| 26 | AMERIPRISE FINANCIAL INC | 227,010 | 8,441,000 | 0.63% | ||
| 27 | COLUMBUS CIRCLE INVESTORS | 209,009 | 7,773,000 | 0.58% | ||
| 28 | WELLS FARGO & COMPANY/MN | 205,773 | 7,653,000 | 0.57% | ||
| 29 | Rock Springs Capital Management LP | 187,500 | 6,973,000 | 0.52% | ||
| 30 | OXFORD ASSET MANAGEMENT LLP | 166,081 | 6,262,000 | 0.47% | ||
| 31 | LORD, ABBETT & CO. LLC | 149,141 | 5,547,000 | 0.41% | ||
| 32 | FRED ALGER MANAGEMENT, LLC | 145,692 | 5,418,000 | 0.40% | ||
| 33 | Candriam S.C.A. | 136,000 | 5,058,000 | 0.38% | ||
| 34 | AMUNDI ASSET MANAGEMENT US, INC. | 128,671 | 4,785,000 | 0.36% | ||
| 35 | TEACHERS ADVISORS, LLC | 125,858 | 4,681,000 | 0.35% | ||
| 36 | CLOUGH CAPITAL PARTNERS L P | 120,300 | 4,474,000 | 0.33% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 118,347 | 4,401,000 | 0.33% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 118,056 | 4,390,000 | 0.33% | ||
| 39 | GUGGENHEIM CAPITAL LLC | 107,064 | 3,982,000 | 0.30% | ||
| 40 | EverPoint Asset Management, LLC | 100,000 | 3,719,000 | 0.28% | ||
| 41 | Bank of New York Mellon Corp | 99,632 | 3,705,000 | 0.28% | ||
| 42 | SUFFOLK CAPITAL MANAGEMENT LLC | 78,300 | 2,912,000 | 0.22% | ||
| 43 | EVENTIDE ASSET MANAGEMENT, LLC | 75,000 | 2,789,000 | 0.21% | ||
| 44 | MASON STREET ADVISORS, LLC | 68,400 | 2,544,000 | 0.19% | ||
| 45 | MACQUARIE GROUP LTD | 64,795 | 2,410,000 | 0.18% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 63,970 | 2,379,000 | 0.18% | ||
| 47 | TD ASSET MANAGEMENT INC | 63,006 | 2,343,000 | 0.17% | ||
| 48 | Rhenman & Partners Asset Management AB | 62,651 | 2,330,000 | 0.17% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 57,069 | 2,123,000 | 0.16% | ||
| 50 | BlackRock Investment Management, LLC | 52,308 | 1,945,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
