| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Capital Research Global Investors | 19,643,043 | 1,627,230,000 | 11.50% | ||
| 2 | VANGUARD GROUP INC | 13,207,286 | 1,094,091,000 | 7.73% | ||
| 3 | SANDS CAPITAL MANAGEMENT, LLC | 9,380,802 | 777,106,000 | 5.49% | ||
| 4 | JENNISON ASSOCIATES LLC | 9,263,458 | 767,385,000 | 5.42% | ||
| 5 | FMR LLC | 8,890,514 | 736,490,000 | 5.20% | ||
| 6 | PRIMECAP MANAGEMENT CO/CA/ | 7,885,948 | 653,272,000 | 4.61% | ||
| 7 | BAKER BROS. ADVISORS LP | 4,806,483 | 398,169,000 | 2.81% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 4,373,022 | 362,261,000 | 2.56% | ||
| 9 | BlackRock Fund Advisors | 4,288,652 | 355,272,000 | 2.51% | ||
| 10 | STATE STREET CORP | 3,743,112 | 310,094,000 | 2.19% | ||
| 11 | Temasek Holdings (Private) Ltd | 3,472,712 | 287,679,000 | 2.03% | ||
| 12 | Invesco Ltd. | 3,387,768 | 280,642,000 | 1.98% | ||
| 13 | JPMORGAN CHASE & CO | 3,237,468 | 268,192,000 | 1.89% | ||
| 14 | WELLS FARGO & COMPANY/MN | 2,278,123 | 188,720,000 | 1.33% | ||
| 15 | Bank of New York Mellon Corp | 2,225,354 | 184,347,000 | 1.30% | ||
| 16 | MANNING & NAPIER ADVISORS LLC | 2,027,930 | 167,992,000 | 1.19% | ||
| 17 | Palo Alto Investors LP | 1,960,219 | 162,385,000 | 1.15% | ||
| 18 | BANK OF AMERICA CORP /DE/ | 1,687,649 | 139,805,000 | 0.99% | ||
| 19 | OppenheimerFunds, Inc. | 1,679,377 | 139,119,000 | 0.98% | ||
| 20 | FRANKLIN RESOURCES INC | 1,621,577 | 134,337,000 | 0.95% | ||
| 21 | AMERIPRISE FINANCIAL INC | 1,574,458 | 130,432,000 | 0.92% | ||
| 22 | DEUTSCHE BANK AG\ | 1,454,562 | 120,492,000 | 0.85% | ||
| 23 | VICTORY CAPITAL MANAGEMENT INC | 1,424,025 | 117,966,000 | 0.83% | ||
| 24 | VIKING GLOBAL INVESTORS LP | 1,398,457 | 115,848,000 | 0.82% | ||
| 25 | GOLDMAN SACHS GROUP INC | 1,380,932 | 114,396,000 | 0.81% | ||
| 26 | ORBIMED ADVISORS LLC | 1,274,100 | 105,546,000 | 0.75% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 1,249,196 | 103,449,000 | 0.73% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 1,223,662 | 101,368,000 | 0.72% | ||
| 29 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,191,423 | 98,697,000 | 0.70% | ||
| 30 | WADDELL & REED FINANCIAL INC | 1,154,424 | 95,632,000 | 0.68% | ||
| 31 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,108,241 | 91,807,000 | 0.65% | ||
| 32 | TCW GROUP INC | 1,093,174 | 90,559,000 | 0.64% | ||
| 33 | BlackRock Group LTD | 1,091,545 | 90,423,000 | 0.64% | ||
| 34 | FRED ALGER MANAGEMENT, LLC | 1,085,133 | 89,892,000 | 0.64% | ||
| 35 | PFM Health Sciences, LP | 1,057,559 | 87,608,000 | 0.62% | ||
| 36 | NORTHERN TRUST CORP | 1,039,518 | 86,114,000 | 0.61% | ||
| 37 | NORGES BANK | 1,013,426 | 83,952,000 | 0.59% | ||
| 38 | PICTET ASSET MANAGEMENT LTD | 999,205 | 82,774,000 | 0.58% | ||
| 39 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 977,491 | 80,975,000 | 0.57% | ||
| 40 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 875,220 | 72,503,000 | 0.51% | ||
| 41 | Alyeska Investment Group, L.P. | 872,701 | 72,295,000 | 0.51% | ||
| 42 | Clearbridge Investments, LLC | 816,295 | 67,622,000 | 0.48% | ||
| 43 | Senator Investment Group LP | 800,000 | 66,272,000 | 0.47% | ||
| 44 | FRONTIER CAPITAL MANAGEMENT CO LLC | 780,052 | 64,620,000 | 0.46% | ||
| 45 | HealthCor Management, L.P. | 775,000 | 64,201,000 | 0.45% | ||
| 46 | PUTNAM INVESTMENTS LLC | 718,883 | 59,552,000 | 0.42% | ||
| 47 | CITADEL ADVISORS LLC | 700,737 | 58,049,000 | 0.41% | ||
| 48 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 670,000 | 55,503,000 | 0.39% | ||
| 49 | Legal & General Group Plc | 669,849 | 55,490,000 | 0.39% | ||
| 50 | Carlson Capital, L.P. | 640,367 | 53,048,000 | 0.37% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
