| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,508,715 | 92,519,000 | 34.57% | ||
| 2 | ORBIMED ADVISORS LLC | 1,989,949 | 40,834,000 | 15.26% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,348,401 | 27,669,000 | 10.34% | ||
| 4 | ADAMS STREET PARTNERS LLC | 1,159,546 | 17,845,000 | 6.67% | ||
| 5 | SECTORAL ASSET MANAGEMENT INC | 862,766 | 17,290,000 | 6.46% | ||
| 6 | RS INVESTMENT MANAGEMENT CO LLC | 623,244 | 12,789,000 | 4.78% | ||
| 7 | RA CAPITAL MANAGEMENT, L.P. | 604,982 | 12,414,000 | 4.64% | ||
| 8 | HAYMAN CAPITAL MANAGEMENT, L.P. | 422,200 | 8,664,000 | 3.24% | ||
| 9 | FRANKLIN RESOURCES INC | 250,100 | 5,132,000 | 1.92% | ||
| 10 | VHCP Management, LLC | 250,000 | 5,130,000 | 1.92% | ||
| 11 | BAKER BROS. ADVISORS LP | 200,000 | 4,104,000 | 1.53% | ||
| 12 | JENNISON ASSOCIATES LLC | 150,381 | 3,086,000 | 1.15% | ||
| 13 | FEDERATED HERMES, INC. | 150,000 | 3,078,000 | 1.15% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 110,965 | 2,277,000 | 0.85% | ||
| 15 | GREENLEAF TRUST | 97,000 | 1,990,000 | 0.74% | ||
| 16 | Lombard Odier Asset Management (USA) Corp | 92,877 | 1,906,000 | 0.71% | ||
| 17 | MORGAN STANLEY | 87,618 | 1,798,000 | 0.67% | ||
| 18 | BLACKROCK ADVISORS LLC | 81,500 | 1,672,000 | 0.62% | ||
| 19 | Candriam S.C.A. | 71,200 | 1,461,000 | 0.55% | ||
| 20 | PICTET ASSET MANAGEMENT LTD | 64,700 | 1,328,000 | 0.50% | ||
| 21 | Cormorant Asset Management, LP | 53,153 | 1,091,000 | 0.41% | ||
| 22 | CAXTON CORP | 45,719 | 938,000 | 0.35% | ||
| 23 | CREDIT SUISSE AG/ | 23,204 | 476,000 | 0.18% | ||
| 24 | Redmile Group, LLC | 18,391 | 377,000 | 0.14% | ||
| 25 | GOLDMAN SACHS GROUP INC | 17,261 | 354,000 | 0.13% | ||
| 26 | CITADEL ADVISORS LLC | 13,356 | 274,000 | 0.10% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 10,622 | 217,000 | 0.08% | ||
| 28 | Weiss Multi-Strategy Advisers LLC | 10,000 | 205,000 | 0.08% | ||
| 29 | BlackRock Group LTD | 9,642 | 198,000 | 0.07% | ||
| 30 | DAFNA Capital Management LLC | 8,500 | 174,000 | 0.07% | ||
| 31 | BlackRock Investment Management, LLC | 5,300 | 109,000 | 0.04% | ||
| 32 | BANK OF MONTREAL /CAN/ | 5,000 | 103,000 | 0.04% | ||
| 33 | CITIGROUP INC | 2,290 | 47,000 | 0.02% | ||
| 34 | Tower Research Capital LLC (TRC) | 2,209 | 45,000 | 0.02% | ||
| 35 | BlackRock Institutional Trust Company, N.A. | 407 | 8,000 | 0.00% | ||
| 36 | UBS Group AG | 396 | 8,000 | 0.00% | ||
| 37 | BNP PARIBAS FINANCIAL MARKETS | 389 | 7,982 | 0.00% | ||
| 38 | BANK OF AMERICA CORP /DE/ | 325 | 7,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
