| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,508,715 | 67,811,000 | 28.30% | ||
| 2 | FRAZIER MANAGEMENT LLC | 2,186,195 | 32,880,000 | 13.72% | ||
| 3 | ORBIMED ADVISORS LLC | 1,989,949 | 29,929,000 | 12.49% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,791,255 | 26,940,000 | 11.24% | ||
| 5 | ADAMS STREET PARTNERS LLC | 1,159,546 | 15,696,000 | 6.55% | ||
| 6 | SECTORAL ASSET MANAGEMENT INC | 910,566 | 14,386,000 | 6.00% | ||
| 7 | RS INVESTMENT MANAGEMENT CO LLC | 699,794 | 10,525,000 | 4.39% | ||
| 8 | RA CAPITAL MANAGEMENT, L.P. | 604,982 | 9,099,000 | 3.80% | ||
| 9 | BlackRock Fund Advisors | 353,551 | 5,317,000 | 2.22% | ||
| 10 | FRANKLIN RESOURCES INC | 250,100 | 3,762,000 | 1.57% | ||
| 11 | BAKER BROS. ADVISORS LP | 200,000 | 3,008,000 | 1.26% | ||
| 12 | GREENLEAF TRUST | 190,812 | 2,870,000 | 1.20% | ||
| 13 | VHCP MANAGEMENT II, LLC | 175,000 | 2,632,000 | 1.10% | ||
| 14 | FEDERATED HERMES, INC. | 150,000 | 2,256,000 | 0.94% | ||
| 15 | Lombard Odier Asset Management (USA) Corp | 96,748 | 1,455,000 | 0.61% | ||
| 16 | VHCP Management, LLC | 75,000 | 1,128,000 | 0.47% | ||
| 17 | Candriam S.C.A. | 71,200 | 1,071,000 | 0.45% | ||
| 18 | QVT Financial LP | 70,000 | 1,053,000 | 0.44% | ||
| 19 | PICTET ASSET MANAGEMENT LTD | 64,700 | 973,000 | 0.41% | ||
| 20 | Cormorant Asset Management, LP | 53,153 | 799,000 | 0.33% | ||
| 21 | CAXTON CORP | 45,719 | 688,000 | 0.29% | ||
| 22 | ALPS ADVISORS INC | 39,597 | 596,000 | 0.25% | ||
| 23 | RENAISSANCE TECHNOLOGIES LLC | 39,000 | 587,000 | 0.24% | ||
| 24 | Opus Point Partners Management, LLC | 30,000 | 451,000 | 0.19% | ||
| 25 | Swiss National Bank | 25,738 | 387,000 | 0.16% | ||
| 26 | Redmile Group, LLC | 24,787 | 373,000 | 0.16% | ||
| 27 | CITADEL ADVISORS LLC | 24,283 | 365,000 | 0.15% | ||
| 28 | ProShare Advisors LLC | 24,173 | 364,000 | 0.15% | ||
| 29 | NEXTHERA CAPITAL LP | 20,000 | 301,000 | 0.13% | ||
| 30 | GOLDMAN SACHS GROUP INC | 19,905 | 299,000 | 0.12% | ||
| 31 | Bank of New York Mellon Corp | 17,529 | 264,000 | 0.11% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,392 | 216,000 | 0.09% | ||
| 33 | A.R.T. Advisors, LLC | 11,900 | 178,000 | 0.07% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 10,780 | 162,000 | 0.07% | ||
| 35 | DAFNA Capital Management LLC | 10,000 | 150,000 | 0.06% | ||
| 36 | Weiss Multi-Strategy Advisers LLC | 10,000 | 150,000 | 0.06% | ||
| 37 | BANK OF AMERICA CORP /DE/ | 6,743 | 101,000 | 0.04% | ||
| 38 | BlackRock Institutional Trust Company, N.A. | 6,652 | 100,000 | 0.04% | ||
| 39 | DEUTSCHE BANK AG\ | 6,000 | 90,000 | 0.04% | ||
| 40 | CITIGROUP INC | 5,034 | 76,000 | 0.03% | ||
| 41 | MORGAN STANLEY | 4,032 | 61,000 | 0.03% | ||
| 42 | PANAGORA ASSET MANAGEMENT INC | 1,802 | 27,000 | 0.01% | ||
| 43 | TEACHER RETIREMENT SYSTEM OF TEXAS | 1,651 | 25,000 | 0.01% | ||
| 44 | BARCLAYS PLC | 514 | 8,000 | 0.00% | ||
| 45 | IFP ADVISORS, INC | 250 | 4,000 | 0.00% | ||
| 46 | Tower Research Capital LLC (TRC) | 209 | 3,000 | 0.00% | ||
| 47 | BNP PARIBAS FINANCIAL MARKETS | 196 | 2,948 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
