| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VIVO CAPITAL, LLC | 2,438,270 | 4,438,000 | 23.76% | ||
| 2 | FRAZIER MANAGEMENT LLC | 2,186,195 | 3,979,000 | 21.30% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,387,115 | 2,525,000 | 13.52% | ||
| 4 | PNC FINANCIAL SERVICES GROUP, INC. | 707,404 | 1,287,000 | 6.89% | ||
| 5 | SABBY MANAGEMENT, LLC | 687,734 | 1,252,000 | 6.70% | ||
| 6 | BlackRock Fund Advisors | 423,892 | 771,000 | 4.13% | ||
| 7 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 335,300 | 610,000 | 3.27% | ||
| 8 | RENAISSANCE TECHNOLOGIES LLC | 225,800 | 411,000 | 2.20% | ||
| 9 | SECTORAL ASSET MANAGEMENT INC | 201,660 | 399,000 | 2.14% | ||
| 10 | BAKER BROS. ADVISORS LP | 200,000 | 364,000 | 1.95% | ||
| 11 | FMR LLC | 197,100 | 359,000 | 1.92% | ||
| 12 | GREENLEAF TRUST | 193,786 | 353,000 | 1.89% | ||
| 13 | DEUTSCHE BANK AG\ | 170,298 | 309,000 | 1.65% | ||
| 14 | JPMORGAN CHASE & CO | 161,540 | 294,000 | 1.57% | ||
| 15 | VHCP MANAGEMENT II, LLC | 130,798 | 238,000 | 1.27% | ||
| 16 | Minerva Advisors LLC | 114,309 | 208,000 | 1.11% | ||
| 17 | PANAGORA ASSET MANAGEMENT INC | 83,443 | 152,000 | 0.81% | ||
| 18 | VHCP Management, LLC | 56,056 | 102,000 | 0.55% | ||
| 19 | ALPS ADVISORS INC | 38,468 | 70,000 | 0.37% | ||
| 20 | D. E. Shaw & Co., Inc. | 33,698 | 61,000 | 0.33% | ||
| 21 | Virtu KCG Holdings LLC | 25,688 | 47,000 | 0.25% | ||
| 22 | WEDBUSH SECURITIES INC | 24,323 | 44,000 | 0.24% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,925 | 44,000 | 0.24% | ||
| 24 | Integre Asset Management, LLC | 23,137 | 42,000 | 0.22% | ||
| 25 | FNY Managed Accounts LLC | 20,000 | 36,400 | 0.19% | ||
| 26 | ProShare Advisors LLC | 19,118 | 35,000 | 0.19% | ||
| 27 | BLAIR WILLIAM & CO/IL | 18,380 | 33,000 | 0.18% | ||
| 28 | Connor, Clark & Lunn Investment Management Ltd. | 14,800 | 27,000 | 0.14% | ||
| 29 | Tower Research Capital LLC (TRC) | 14,016 | 26,000 | 0.14% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 13,195 | 24,000 | 0.13% | ||
| 31 | TWO SIGMA SECURITIES, LLC | 12,822 | 23,000 | 0.12% | ||
| 32 | RAYMOND JAMES TRUST N.A. | 11,614 | 21,000 | 0.11% | ||
| 33 | GOLDMAN SACHS GROUP INC | 10,982 | 20,000 | 0.11% | ||
| 34 | COMERICA BANK | 10,331 | 19,000 | 0.10% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 9,730 | 18,000 | 0.10% | ||
| 36 | ACADIAN ASSET MANAGEMENT LLC | 8,785 | 16,000 | 0.09% | ||
| 37 | CITIGROUP INC | 4,891 | 9,000 | 0.05% | ||
| 38 | MORGAN STANLEY | 3,450 | 6,000 | 0.03% | ||
| 39 | ROYAL BANK OF CANADA | 1,375 | 2,000 | 0.01% | ||
| 40 | BARCLAYS PLC | 1,271 | 2,000 | 0.01% | ||
| 41 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 791 | 1,000 | 0.01% | ||
| 42 | BNP PARIBAS FINANCIAL MARKETS | 104 | 189 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
