| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VIVO CAPITAL, LLC | 2,438,270 | 4,852,000 | 18.94% | ||
| 2 | FRAZIER MANAGEMENT LLC | 2,186,195 | 4,351,000 | 16.99% | ||
| 3 | PICTET ASSET MANAGEMENT LTD | 684,433 | 4,298,000 | 16.78% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,608,702 | 3,201,000 | 12.50% | ||
| 5 | ADAMS STREET PARTNERS LLC | 738,422 | 1,469,000 | 5.73% | ||
| 6 | SECTORAL ASSET MANAGEMENT INC | 201,660 | 1,359,000 | 5.31% | ||
| 7 | PNC FINANCIAL SERVICES GROUP, INC. | 601,092 | 1,197,000 | 4.67% | ||
| 8 | SABBY MANAGEMENT, LLC | 590,011 | 1,174,000 | 4.58% | ||
| 9 | BlackRock Fund Advisors | 396,221 | 788,000 | 3.08% | ||
| 10 | GREENLEAF TRUST | 207,450 | 413,000 | 1.61% | ||
| 11 | BAKER BROS. ADVISORS LP | 200,000 | 398,000 | 1.55% | ||
| 12 | FMR LLC | 197,100 | 392,000 | 1.53% | ||
| 13 | VHCP MANAGEMENT II, LLC | 130,798 | 260,000 | 1.01% | ||
| 14 | Minerva Advisors LLC | 114,309 | 227,000 | 0.89% | ||
| 15 | PANAGORA ASSET MANAGEMENT INC | 84,332 | 168,000 | 0.66% | ||
| 16 | QVT Financial LP | 70,000 | 139,000 | 0.54% | ||
| 17 | VHCP Management, LLC | 56,056 | 112,000 | 0.44% | ||
| 18 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 55,000 | 109,000 | 0.43% | ||
| 19 | ALPS ADVISORS INC | 42,389 | 84,000 | 0.33% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 35,800 | 71,000 | 0.28% | ||
| 21 | MORGAN STANLEY | 30,967 | 62,000 | 0.24% | ||
| 22 | RA CAPITAL MANAGEMENT, L.P. | 29,719 | 59,000 | 0.23% | ||
| 23 | ProShare Advisors LLC | 22,465 | 45,000 | 0.18% | ||
| 24 | Virtu KCG Holdings LLC | 21,085 | 42,000 | 0.16% | ||
| 25 | WEDBUSH SECURITIES INC | 16,823 | 33,000 | 0.13% | ||
| 26 | BLAIR WILLIAM & CO/IL | 16,688 | 33,000 | 0.13% | ||
| 27 | BANK OF AMERICA CORP /DE/ | 15,941 | 32,000 | 0.12% | ||
| 28 | DEUTSCHE BANK AG\ | 15,115 | 29,000 | 0.11% | ||
| 29 | Dynamic Technology Lab Private Ltd | 12,929 | 26,000 | 0.10% | ||
| 30 | ACADIAN ASSET MANAGEMENT LLC | 12,847 | 26,000 | 0.10% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 13,116 | 26,000 | 0.10% | ||
| 32 | A.R.T. Advisors, LLC | 12,100 | 24,000 | 0.09% | ||
| 33 | RAYMOND JAMES TRUST N.A. | 11,614 | 23,000 | 0.09% | ||
| 34 | Connor, Clark & Lunn Investment Management Ltd. | 11,000 | 22,000 | 0.09% | ||
| 35 | COMERICA BANK | 10,331 | 20,000 | 0.08% | ||
| 36 | BARCLAYS PLC | 7,815 | 16,000 | 0.06% | ||
| 37 | CITIGROUP INC | 4,064 | 8,000 | 0.03% | ||
| 38 | UBS Group AG | 4,141 | 8,000 | 0.03% | ||
| 39 | Plante Moran Financial Advisors, LLC | 4,230 | 8,000 | 0.03% | ||
| 40 | Tower Research Capital LLC (TRC) | 1,741 | 4,000 | 0.02% | ||
| 41 | WOLVERINE TRADING LP /BD | 1,777 | 3,590 | 0.01% | ||
| 42 | ROYAL BANK OF CANADA | 1,375 | 2,000 | 0.01% | ||
| 43 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 791 | 2,000 | 0.01% | ||
| 44 | BNP PARIBAS FINANCIAL MARKETS | 104 | 207 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
