| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,407,715 | 29,708,000 | 21.14% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,001,302 | 20,229,000 | 14.39% | ||
| 3 | VIVO CAPITAL, LLC | 2,438,270 | 16,434,000 | 11.69% | ||
| 4 | FRAZIER MANAGEMENT LLC | 2,186,195 | 14,735,000 | 10.48% | ||
| 5 | ORBIMED ADVISORS LLC | 1,623,149 | 10,940,000 | 7.78% | ||
| 6 | SECTORAL ASSET MANAGEMENT INC | 1,137,073 | 7,664,000 | 5.45% | ||
| 7 | ADAMS STREET PARTNERS LLC | 1,121,715 | 7,560,000 | 5.38% | ||
| 8 | RS INVESTMENT MANAGEMENT CO LLC | 980,303 | 6,607,000 | 4.70% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 801,189 | 5,400,000 | 3.84% | ||
| 10 | RA CAPITAL MANAGEMENT, L.P. | 604,982 | 4,078,000 | 2.90% | ||
| 11 | PNC FINANCIAL SERVICES GROUP, INC. | 574,866 | 3,874,000 | 2.76% | ||
| 12 | BlackRock Fund Advisors | 389,075 | 2,622,000 | 1.87% | ||
| 13 | FRANKLIN RESOURCES INC | 250,100 | 1,686,000 | 1.20% | ||
| 14 | BAKER BROS. ADVISORS LP | 200,000 | 1,348,000 | 0.96% | ||
| 15 | GREENLEAF TRUST | 192,494 | 1,297,000 | 0.92% | ||
| 16 | VHCP MANAGEMENT II, LLC | 130,798 | 882,000 | 0.63% | ||
| 17 | QVT Financial LP | 70,000 | 472,000 | 0.34% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,158 | 405,000 | 0.29% | ||
| 19 | PICTET ASSET MANAGEMENT LTD | 64,700 | 381,000 | 0.27% | ||
| 20 | VHCP Management, LLC | 56,056 | 378,000 | 0.27% | ||
| 21 | Cormorant Asset Management, LP | 53,153 | 358,000 | 0.25% | ||
| 22 | Lombard Odier Asset Management (USA) Corp | 49,888 | 336,000 | 0.24% | ||
| 23 | NORRIS PERNE & FRENCH LLP/MI | 47,244 | 318,000 | 0.23% | ||
| 24 | RENAISSANCE TECHNOLOGIES LLC | 45,300 | 305,000 | 0.22% | ||
| 25 | GOLDMAN SACHS GROUP INC | 43,757 | 295,000 | 0.21% | ||
| 26 | ALPS ADVISORS INC | 33,803 | 228,000 | 0.16% | ||
| 27 | Swiss National Bank | 31,538 | 206,000 | 0.15% | ||
| 28 | COMERICA BANK | 30,331 | 200,000 | 0.14% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 29,700 | 200,000 | 0.14% | ||
| 30 | ProShare Advisors LLC | 22,089 | 149,000 | 0.11% | ||
| 31 | VIRTUS ETF ADVISERS LLC | 17,902 | 121,000 | 0.09% | ||
| 32 | DEUTSCHE BANK AG\ | 17,758 | 119,000 | 0.08% | ||
| 33 | Bank of New York Mellon Corp | 17,129 | 115,000 | 0.08% | ||
| 34 | A.R.T. Advisors, LLC | 16,100 | 108,000 | 0.08% | ||
| 35 | CREDIT SUISSE AG/ | 14,830 | 99,000 | 0.07% | ||
| 36 | DekaBank Deutsche Girozentrale | 14,000 | 97,000 | 0.07% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 13,116 | 88,000 | 0.06% | ||
| 38 | ACADIAN ASSET MANAGEMENT LLC | 12,941 | 87,000 | 0.06% | ||
| 39 | Raymond James Financial Services Advisors, Inc. | 12,592 | 85,000 | 0.06% | ||
| 40 | MORGAN STANLEY | 11,005 | 73,000 | 0.05% | ||
| 41 | DAFNA Capital Management LLC | 10,000 | 67,000 | 0.05% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 7,400 | 50,000 | 0.04% | ||
| 43 | BlackRock Institutional Trust Company, N.A. | 6,652 | 45,000 | 0.03% | ||
| 44 | CITIGROUP INC | 4,258 | 29,000 | 0.02% | ||
| 45 | JPMORGAN CHASE & CO | 4,100 | 28,000 | 0.02% | ||
| 46 | BlackRock Group LTD | 3,158 | 21,000 | 0.01% | ||
| 47 | TEACHER RETIREMENT SYSTEM OF TEXAS | 2,220 | 15,000 | 0.01% | ||
| 48 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 791 | 6,000 | 0.00% | ||
| 49 | Tower Research Capital LLC (TRC) | 600 | 4,000 | 0.00% | ||
| 50 | BARCLAYS PLC | 191 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
