| 1 |
IFP ADVISORS, INC |
30 |
0 |
0.00% |
|
|
| 2 |
BNP PARIBAS FINANCIAL MARKETS |
103 |
694 |
0.00% |
|
|
| 3 |
BARCLAYS PLC |
191 |
1,000 |
0.00% |
|
|
| 4 |
Tower Research Capital LLC (TRC) |
600 |
4,000 |
0.00% |
|
|
| 5 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
791 |
6,000 |
0.00% |
|
|
| 6 |
TEACHER RETIREMENT SYSTEM OF TEXAS |
2,220 |
15,000 |
0.01% |
|
|
| 7 |
BlackRock Group LTD |
3,158 |
21,000 |
0.01% |
|
|
| 8 |
JPMORGAN CHASE & CO |
4,100 |
28,000 |
0.02% |
|
|
| 9 |
CITIGROUP INC |
4,258 |
29,000 |
0.02% |
|
|
| 10 |
BlackRock Institutional Trust Company, N.A. |
6,652 |
45,000 |
0.03% |
|
|
| 11 |
BANK OF AMERICA CORP /DE/ |
7,400 |
50,000 |
0.04% |
|
|
| 12 |
DAFNA Capital Management LLC |
10,000 |
67,000 |
0.05% |
|
|
| 13 |
MORGAN STANLEY |
11,005 |
73,000 |
0.05% |
|
|
| 14 |
Raymond James Financial Services Advisors, Inc. |
12,592 |
85,000 |
0.06% |
|
|
| 15 |
ACADIAN ASSET MANAGEMENT LLC |
12,941 |
87,000 |
0.06% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
13,116 |
88,000 |
0.06% |
|
|
| 17 |
DekaBank Deutsche Girozentrale |
14,000 |
97,000 |
0.07% |
|
|
| 18 |
CREDIT SUISSE AG/ |
14,830 |
99,000 |
0.07% |
|
|
| 19 |
A.R.T. Advisors, LLC |
16,100 |
108,000 |
0.08% |
|
|
| 20 |
Bank of New York Mellon Corp |
17,129 |
115,000 |
0.08% |
|
|
| 21 |
DEUTSCHE BANK AG\ |
17,758 |
119,000 |
0.08% |
|
|
| 22 |
VIRTUS ETF ADVISERS LLC |
17,902 |
121,000 |
0.09% |
|
|
| 23 |
ProShare Advisors LLC |
22,089 |
149,000 |
0.11% |
|
|
| 24 |
MILLENNIUM MANAGEMENT LLC |
29,700 |
200,000 |
0.14% |
|
|
| 25 |
COMERICA BANK |
30,331 |
200,000 |
0.14% |
|
|
| 26 |
Swiss National Bank |
31,538 |
206,000 |
0.15% |
|
|
| 27 |
ALPS ADVISORS INC |
33,803 |
228,000 |
0.16% |
|
|
| 28 |
GOLDMAN SACHS GROUP INC |
43,757 |
295,000 |
0.21% |
|
|
| 29 |
RENAISSANCE TECHNOLOGIES LLC |
45,300 |
305,000 |
0.22% |
|
|
| 30 |
NORRIS PERNE & FRENCH LLP/MI |
47,244 |
318,000 |
0.23% |
|
|
| 31 |
Lombard Odier Asset Management (USA) Corp |
49,888 |
336,000 |
0.24% |
|
|
| 32 |
Cormorant Asset Management, LP |
53,153 |
358,000 |
0.25% |
|
|
| 33 |
VHCP Management, LLC |
56,056 |
378,000 |
0.27% |
|
|
| 34 |
PICTET ASSET MANAGEMENT LTD |
64,700 |
381,000 |
0.27% |
|
|
| 35 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
60,158 |
405,000 |
0.29% |
|
|
| 36 |
QVT Financial LP |
70,000 |
472,000 |
0.34% |
|
|
| 37 |
VHCP MANAGEMENT II, LLC |
130,798 |
882,000 |
0.63% |
|
|
| 38 |
GREENLEAF TRUST |
192,494 |
1,297,000 |
0.92% |
|
|
| 39 |
BAKER BROS. ADVISORS LP |
200,000 |
1,348,000 |
0.96% |
|
|
| 40 |
FRANKLIN RESOURCES INC |
250,100 |
1,686,000 |
1.20% |
|
|
| 41 |
BlackRock Fund Advisors |
389,075 |
2,622,000 |
1.87% |
|
|
| 42 |
PNC FINANCIAL SERVICES GROUP, INC. |
574,866 |
3,874,000 |
2.76% |
|
|
| 43 |
RA CAPITAL MANAGEMENT, L.P. |
604,982 |
4,078,000 |
2.90% |
|
|
| 44 |
JANUS HENDERSON INVESTORS US LLC |
801,189 |
5,400,000 |
3.84% |
|
|
| 45 |
RS INVESTMENT MANAGEMENT CO LLC |
980,303 |
6,607,000 |
4.70% |
|
|
| 46 |
ADAMS STREET PARTNERS LLC |
1,121,715 |
7,560,000 |
5.38% |
|
|
| 47 |
SECTORAL ASSET MANAGEMENT INC |
1,137,073 |
7,664,000 |
5.45% |
|
|
| 48 |
ORBIMED ADVISORS LLC |
1,623,149 |
10,940,000 |
7.78% |
|
|
| 49 |
FRAZIER MANAGEMENT LLC |
2,186,195 |
14,735,000 |
10.48% |
|
|
| 50 |
VIVO CAPITAL, LLC |
2,438,270 |
16,434,000 |
11.69% |
|
|
