| 1 |
VIVO CAPITAL, LLC |
1,599,591 |
31,704,000 |
49.51% |
|
|
| 2 |
RA CAPITAL MANAGEMENT, L.P. |
291,700 |
5,781,000 |
9.03% |
|
|
| 3 |
SABBY MANAGEMENT, LLC |
175,249 |
3,473,000 |
5.42% |
|
|
| 4 |
SPHERA FUNDS MANAGEMENT LTD. |
150,716 |
2,987,000 |
4.66% |
|
|
| 5 |
Lombard Odier Asset Management (USA) Corp |
143,638 |
2,847,000 |
4.45% |
|
|
| 6 |
VANGUARD GROUP INC |
124,787 |
2,473,000 |
3.86% |
|
|
| 7 |
WELLINGTON MANAGEMENT GROUP LLP |
117,519 |
2,330,000 |
3.64% |
|
|
| 8 |
PERCEPTIVE ADVISORS LLC |
104,920 |
2,079,000 |
3.25% |
|
|
| 9 |
BOXER CAPITAL, LLC |
93,331 |
1,850,000 |
2.89% |
|
|
| 10 |
BlackRock Fund Advisors |
90,256 |
1,789,000 |
2.79% |
|
|
| 11 |
MONASHEE INVESTMENT MANAGEMENT LLC |
84,680 |
1,678,000 |
2.62% |
|
PRN |
| 12 |
BlackRock Institutional Trust Company, N.A. |
37,184 |
737,000 |
1.15% |
|
|
| 13 |
NORTHERN TRUST CORP |
33,717 |
668,000 |
1.04% |
|
|
| 14 |
DEUTSCHE BANK AG\ |
31,714 |
627,000 |
0.98% |
|
|
| 15 |
STATE STREET CORP |
21,548 |
428,000 |
0.67% |
|
|
| 16 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
15,900 |
315,000 |
0.49% |
|
|
| 17 |
EcoR1 Capital, LLC |
14,190 |
281,000 |
0.44% |
|
|
| 18 |
NEXTHERA CAPITAL LP |
14,000 |
277,000 |
0.43% |
|
|
| 19 |
BlackRock Investment Management, LLC |
12,355 |
245,000 |
0.38% |
|
|
| 20 |
Bank of New York Mellon Corp |
10,778 |
214,000 |
0.33% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
10,786 |
214,000 |
0.33% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
10,049 |
199,000 |
0.31% |
|
|
| 23 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
10,000 |
198,000 |
0.31% |
|
|
| 24 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
7,262 |
144,000 |
0.22% |
|
|
| 25 |
TEACHERS ADVISORS, LLC |
5,474 |
108,000 |
0.17% |
|
|
| 26 |
NEW YORK STATE COMMON RETIREMENT FUND |
5,400 |
107,000 |
0.17% |
|
|
| 27 |
BELLEVUE GROUP AG |
3,333 |
66,000 |
0.10% |
|
|
| 28 |
Nationwide Fund Advisors |
2,082 |
41,000 |
0.06% |
|
|
| 29 |
AMERICAN INTERNATIONAL GROUP, INC. |
1,993 |
39,501 |
0.06% |
|
|
| 30 |
BLACKROCK ADVISORS LLC |
1,225 |
24,000 |
0.04% |
|
|
| 31 |
STRS OHIO |
1,200 |
23,000 |
0.04% |
|
|
| 32 |
CUTLER GROUP LLC / CA |
1,189 |
23,000 |
0.04% |
|
|
| 33 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
1,000 |
20,000 |
0.03% |
|
|
| 34 |
CITIGROUP INC |
526 |
11,000 |
0.02% |
|
|
| 35 |
Creative Planning |
402 |
8,000 |
0.01% |
|
|
| 36 |
WOLVERINE TRADING LP /BD |
329 |
6,159 |
0.01% |
|
|
| 37 |
BlackRock Finance, Inc. |
150 |
3,000 |
0.00% |
|
|
| 38 |
MSI Financial Services Inc |
133 |
3,000 |
0.00% |
|
|
| 39 |
BNP PARIBAS FINANCIAL MARKETS |
137 |
2,715 |
0.00% |
|
|
| 40 |
MORGAN STANLEY |
100 |
2,000 |
0.00% |
|
|
| 41 |
Walleye Trading LLC |
114 |
2,000 |
0.00% |
|
|
| 42 |
WELLS FARGO & COMPANY/MN |
80 |
2,000 |
0.00% |
|
|
| 43 |
IFP ADVISORS, INC |
40 |
1,000 |
0.00% |
|
|
| 44 |
BANK OF AMERICA CORP /DE/ |
69 |
1,000 |
0.00% |
|
|
| 45 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
46 |
1,000 |
0.00% |
|
|
| 46 |
BARCLAYS PLC |
4 |
0 |
0.00% |
|
|
| 47 |
GROUP ONE TRADING LLC |
20 |
0 |
0.00% |
|
|
| 48 |
UBS Group AG |
5 |
0 |
0.00% |
|
|
