| 1 |
VIVO CAPITAL, LLC |
1,787,091 |
23,929,000 |
39.53% |
|
|
| 2 |
SPHERA FUNDS MANAGEMENT LTD. |
373,568 |
5,002,000 |
8.26% |
|
|
| 3 |
RA CAPITAL MANAGEMENT, L.P. |
354,200 |
4,743,000 |
7.84% |
|
|
| 4 |
WELLINGTON MANAGEMENT GROUP LLP |
294,839 |
3,948,000 |
6.52% |
|
|
| 5 |
NEXTHERA CAPITAL LP |
264,000 |
3,535,000 |
5.84% |
|
|
| 6 |
SABBY MANAGEMENT, LLC |
230,803 |
3,090,000 |
5.10% |
|
|
| 7 |
Lombard Odier Asset Management (USA) Corp |
163,638 |
2,191,000 |
3.62% |
|
|
| 8 |
VANGUARD GROUP INC |
146,452 |
1,961,000 |
3.24% |
|
|
| 9 |
BOXER CAPITAL, LLC |
138,331 |
1,852,000 |
3.06% |
|
|
| 10 |
PERCEPTIVE ADVISORS LLC |
129,920 |
1,739,000 |
2.87% |
|
|
| 11 |
BlackRock Fund Advisors |
110,882 |
1,485,000 |
2.45% |
|
|
| 12 |
Board of Trustees of The Leland Stanford Junior University |
109,053 |
1,460,000 |
2.41% |
|
|
| 13 |
DAFNA Capital Management LLC |
90,000 |
1,205,000 |
1.99% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
40,517 |
543,000 |
0.90% |
|
|
| 15 |
NORTHERN TRUST CORP |
37,212 |
498,000 |
0.82% |
|
|
| 16 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
35,665 |
478,000 |
0.79% |
|
|
| 17 |
MONASHEE INVESTMENT MANAGEMENT LLC |
31,500 |
422,000 |
0.70% |
|
PRN |
| 18 |
DEUTSCHE BANK AG\ |
27,663 |
369,000 |
0.61% |
|
|
| 19 |
STATE STREET CORP |
26,791 |
357,000 |
0.59% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
26,547 |
355,000 |
0.59% |
|
|
| 21 |
EMERALD ACQUISITION LTD. |
12,627 |
169,000 |
0.28% |
|
|
| 22 |
BlackRock Investment Management, LLC |
12,459 |
167,000 |
0.28% |
|
|
| 23 |
Bank of New York Mellon Corp |
12,319 |
165,000 |
0.27% |
|
|
| 24 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
10,786 |
144,000 |
0.24% |
|
|
| 25 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
10,000 |
134,000 |
0.22% |
|
|
| 26 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
8,762 |
117,000 |
0.19% |
|
|
| 27 |
TEACHERS ADVISORS, LLC |
5,474 |
73,000 |
0.12% |
|
|
| 28 |
NEW YORK STATE COMMON RETIREMENT FUND |
5,400 |
72,000 |
0.12% |
|
|
| 29 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
5,027 |
67,000 |
0.11% |
|
|
| 30 |
BELLEVUE GROUP AG |
3,333 |
45,000 |
0.07% |
|
|
| 31 |
WELLS FARGO & COMPANY/MN |
3,026 |
41,000 |
0.07% |
|
|
| 32 |
BLACKROCK ADVISORS LLC |
2,953 |
40,000 |
0.07% |
|
|
| 33 |
Nationwide Fund Advisors |
2,082 |
28,000 |
0.05% |
|
|
| 34 |
AMERICAN INTERNATIONAL GROUP, INC. |
1,996 |
26,726 |
0.04% |
|
|
| 35 |
STRS OHIO |
1,200 |
16,000 |
0.03% |
|
|
| 36 |
CUTLER GROUP LLC / CA |
1,132 |
15,000 |
0.02% |
|
|
| 37 |
MORGAN STANLEY |
867 |
11,000 |
0.02% |
|
|
| 38 |
UBS Group AG |
722 |
10,000 |
0.02% |
|
|
| 39 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
650 |
9,000 |
0.01% |
|
|
| 40 |
BANK OF AMERICA CORP /DE/ |
426 |
6,000 |
0.01% |
|
|
| 41 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
326 |
4,000 |
0.01% |
|
|
| 42 |
BNP PARIBAS FINANCIAL MARKETS |
282 |
3,776 |
0.01% |
|
|
| 43 |
CITIGROUP INC |
133 |
2,000 |
0.00% |
|
|
| 44 |
Tower Research Capital LLC (TRC) |
141 |
2,000 |
0.00% |
|
|
| 45 |
MSI Financial Services Inc |
133 |
2,000 |
0.00% |
|
|
| 46 |
BlackRock Finance, Inc. |
150 |
2,000 |
0.00% |
|
|
| 47 |
Creative Planning |
2 |
0 |
0.00% |
|
|
| 48 |
GROUP ONE TRADING LLC |
20 |
0 |
0.00% |
|
|
| 49 |
Walleye Trading LLC |
14 |
0 |
0.00% |
|
|
| 50 |
BARCLAYS PLC |
30 |
0 |
0.00% |
|
|
