| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 9,001,778 | 26,915,000 | 24.12% | ||
| 2 | QVT Financial LP | 5,628,899 | 16,830,000 | 15.08% | ||
| 3 | FRANKLIN RESOURCES INC | 4,256,600 | 12,727,000 | 11.41% | ||
| 4 | First Eagle Investment Management, LLC | 2,724,987 | 8,148,000 | 7.30% | ||
| 5 | BlackRock Institutional Trust Company, N.A. | 2,198,646 | 6,574,000 | 5.89% | ||
| 6 | VANGUARD GROUP INC | 1,764,608 | 5,277,000 | 4.73% | ||
| 7 | GREAT POINT PARTNERS LLC | 991,800 | 2,965,000 | 2.66% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 950,000 | 2,841,000 | 2.55% | ||
| 9 | Employees Retirement System of Texas | 891,000 | 2,664,000 | 2.39% | ||
| 10 | SPHERA FUNDS MANAGEMENT LTD. | 738,336 | 2,208,000 | 1.98% | ||
| 11 | D. E. Shaw & Co., Inc. | 726,013 | 2,171,000 | 1.95% | ||
| 12 | DRIEHAUS CAPITAL MANAGEMENT LLC | 642,771 | 1,922,000 | 1.72% | ||
| 13 | PERCEPTIVE ADVISORS LLC | 543,000 | 1,624,000 | 1.46% | ||
| 14 | PERKINS CAPITAL MANAGEMENT INC | 491,450 | 1,469,000 | 1.32% | ||
| 15 | TFS CAPITAL LLC | 360,035 | 1,077,000 | 0.97% | ||
| 16 | DEUTSCHE BANK AG\ | 354,818 | 1,060,000 | 0.95% | ||
| 17 | FMR LLC | 343,600 | 1,027,000 | 0.92% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 339,400 | 1,015,000 | 0.91% | Call | |
| 19 | MORGAN STANLEY | 322,259 | 963,000 | 0.86% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 296,430 | 886,000 | 0.79% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 290,524 | 868,000 | 0.78% | ||
| 22 | CREDIT SUISSE AG/ | 289,791 | 866,000 | 0.78% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 251,186 | 751,000 | 0.67% | ||
| 24 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 227,988 | 682,000 | 0.61% | ||
| 25 | BlackRock Fund Advisors | 209,325 | 626,000 | 0.56% | ||
| 26 | Allianz Asset Management GmbH | 200,300 | 599,000 | 0.54% | ||
| 27 | UBS AG | 188,337 | 563,000 | 0.50% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 170,900 | 511,000 | 0.46% | Put | |
| 29 | BlackRock Group LTD | 129,934 | 389,000 | 0.35% | ||
| 30 | PANAGORA ASSET MANAGEMENT INC | 127,377 | 381,000 | 0.34% | ||
| 31 | OXFORD ASSET MANAGEMENT LLP | 122,244 | 366,000 | 0.33% | ||
| 32 | NORTHERN TRUST CORP | 104,640 | 313,000 | 0.28% | ||
| 33 | JANE STREET GROUP, LLC | 102,745 | 307,000 | 0.28% | ||
| 34 | Weiss Multi-Strategy Advisers LLC | 100,000 | 299,000 | 0.27% | ||
| 35 | Bank of New York Mellon Corp | 97,774 | 292,000 | 0.26% | ||
| 36 | SOROS FUND MANAGEMENT LLC | 89,600 | 268,000 | 0.24% | ||
| 37 | Virtu KCG Holdings LLC | 72,597 | 216,000 | 0.19% | ||
| 38 | NOMURA HOLDINGS INC | 66,782 | 205,000 | 0.18% | ||
| 39 | NOMURA HOLDINGS INC | 65,000 | 200,000 | 0.18% | Call | |
| 40 | LMR Partners LLP | 61,212 | 183,000 | 0.16% | ||
| 41 | WELLS FARGO & COMPANY/MN | 49,613 | 148,000 | 0.13% | ||
| 42 | A.R.T. Advisors, LLC | 49,641 | 148,000 | 0.13% | ||
| 43 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 47,800 | 142,000 | 0.13% | ||
| 44 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 41,396 | 124,000 | 0.11% | ||
| 45 | US BANCORP \DE\ | 38,216 | 114,000 | 0.10% | ||
| 46 | GOLDMAN SACHS GROUP INC | 36,215 | 109,000 | 0.10% | ||
| 47 | JPMORGAN CHASE & CO | 35,510 | 106,000 | 0.09% | ||
| 48 | CITIGROUP INC | 34,056 | 102,000 | 0.09% | ||
| 49 | SHEPHERD KAPLAN KROCHUK, LLC | 33,000 | 99,000 | 0.09% | ||
| 50 | Horizon Kinetics LLC | 32,333 | 97,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
