| 1 |
BVF INC/IL |
18,799,368 |
23,875,000 |
33.31% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
6,899,600 |
8,762,000 |
12.22% |
|
|
| 3 |
Avoro Capital Advisors LLC |
4,069,072 |
5,168,000 |
7.21% |
|
|
| 4 |
BlackRock Fund Advisors |
3,660,555 |
4,649,000 |
6.49% |
|
|
| 5 |
VANGUARD GROUP INC |
3,573,336 |
4,538,000 |
6.33% |
|
|
| 6 |
PERCEPTIVE ADVISORS LLC |
3,414,121 |
4,335,000 |
6.05% |
|
|
| 7 |
BlackRock Institutional Trust Company, N.A. |
2,622,898 |
3,331,000 |
4.65% |
|
|
| 8 |
STATE STREET CORP |
1,627,705 |
2,064,000 |
2.88% |
|
|
| 9 |
Gruss Capital Management LP |
1,106,000 |
1,405,000 |
1.96% |
|
|
| 10 |
NORTHERN TRUST CORP |
1,023,444 |
1,300,000 |
1.81% |
|
|
| 11 |
FT OPTIONS LLC |
1,015,607 |
1,290,000 |
1.80% |
|
|
| 12 |
SABBY MANAGEMENT, LLC |
739,004 |
939,000 |
1.31% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
629,830 |
799,000 |
1.11% |
|
|
| 14 |
DEUTSCHE BANK AG\ |
569,365 |
720,000 |
1.00% |
|
|
| 15 |
JPMORGAN CHASE & CO |
455,000 |
577,000 |
0.80% |
|
|
| 16 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
403,631 |
513,000 |
0.72% |
|
|
| 17 |
BlackRock Investment Management, LLC |
334,586 |
425,000 |
0.59% |
|
|
| 18 |
Bank of New York Mellon Corp |
327,995 |
417,000 |
0.58% |
|
|
| 19 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
316,197 |
402,000 |
0.56% |
|
|
| 20 |
PERKINS CAPITAL MANAGEMENT INC |
311,550 |
396,000 |
0.55% |
|
|
| 21 |
First Eagle Investment Management, LLC |
300,000 |
381,000 |
0.53% |
|
|
| 22 |
Anson Funds Management LP |
685,000 |
367,000 |
0.51% |
|
|
| 23 |
Telemetry Investments, L.L.C. |
276,000 |
351,000 |
0.49% |
|
|
| 24 |
ClariVest Asset Management LLC |
242,000 |
308,000 |
0.43% |
|
|
| 25 |
BLACKROCK ADVISORS LLC |
241,678 |
307,000 |
0.43% |
|
|
| 26 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
221,678 |
282,000 |
0.39% |
|
|
| 27 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
203,768 |
259,000 |
0.36% |
|
|
| 28 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
177,409 |
226,000 |
0.32% |
|
|
| 29 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
167,000 |
212,000 |
0.30% |
|
|
| 30 |
TEACHERS ADVISORS, LLC |
155,140 |
197,000 |
0.27% |
|
|
| 31 |
D. E. Shaw & Co., Inc. |
127,955 |
163,000 |
0.23% |
|
|
| 32 |
AQR CAPITAL MANAGEMENT LLC |
121,216 |
154,000 |
0.21% |
|
|
| 33 |
VIRTUS ETF ADVISERS LLC |
116,667 |
148,000 |
0.21% |
|
|
| 34 |
COWEN INC. |
114,200 |
145,000 |
0.20% |
|
|
| 35 |
RHUMBLINE ADVISERS |
98,452 |
125,000 |
0.17% |
|
|
| 36 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
95,900 |
122,000 |
0.17% |
|
|
| 37 |
Connor, Clark & Lunn Investment Management Ltd. |
95,000 |
121,000 |
0.17% |
|
|
| 38 |
Virtu KCG Holdings LLC |
93,093 |
118,000 |
0.16% |
|
|
| 39 |
A.R.T. Advisors, LLC |
91,793 |
116,000 |
0.16% |
|
|
| 40 |
CITIGROUP INC |
90,742 |
115,000 |
0.16% |
|
|
| 41 |
NEW YORK STATE COMMON RETIREMENT FUND |
84,200 |
107,000 |
0.15% |
|
|
| 42 |
STIFEL FINANCIAL CORP |
83,765 |
106,000 |
0.15% |
|
|
| 43 |
ProShare Advisors LLC |
81,378 |
103,000 |
0.14% |
|
|
| 44 |
ALLIANCEBERNSTEIN L.P. |
73,100 |
93,000 |
0.13% |
|
|
| 45 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
68,135 |
87,000 |
0.12% |
|
|
| 46 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
69,830 |
82,000 |
0.11% |
|
|
| 47 |
Nationwide Fund Advisors |
61,013 |
77,000 |
0.11% |
|
|
| 48 |
AMERICAN INTERNATIONAL GROUP, INC. |
59,917 |
76,000 |
0.11% |
|
|
| 49 |
GOLDMAN SACHS GROUP INC |
54,644 |
69,000 |
0.10% |
|
|
| 50 |
WELLS FARGO & COMPANY/MN |
49,811 |
63,000 |
0.09% |
|
|
