| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 13,762,260 | 26,148,000 | 26.13% | ||
| 2 | QVT Financial LP | 5,044,484 | 9,476,000 | 9.47% | ||
| 3 | FRANKLIN RESOURCES INC | 3,919,800 | 7,448,000 | 7.44% | ||
| 4 | BlackRock Institutional Trust Company, N.A. | 3,142,121 | 5,970,000 | 5.97% | ||
| 5 | Avoro Capital Advisors LLC | 2,991,636 | 5,684,000 | 5.68% | ||
| 6 | VANGUARD GROUP INC | 2,273,683 | 4,320,000 | 4.32% | ||
| 7 | BlackRock Fund Advisors | 2,244,246 | 4,264,000 | 4.26% | ||
| 8 | Broadfin Capital, LLC | 2,000,000 | 3,800,000 | 3.80% | ||
| 9 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1,139,286 | 2,165,000 | 2.16% | ||
| 10 | Gruss Capital Management LP | 1,005,000 | 1,910,000 | 1.91% | ||
| 11 | FMR LLC | 971,900 | 1,847,000 | 1.85% | ||
| 12 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 950,000 | 1,805,000 | 1.80% | ||
| 13 | D. E. Shaw & Co., Inc. | 936,448 | 1,779,000 | 1.78% | ||
| 14 | NORTHERN TRUST CORP | 858,116 | 1,631,000 | 1.63% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 775,000 | 1,473,000 | 1.47% | ||
| 16 | STATE STREET CORP | 753,138 | 1,430,000 | 1.43% | ||
| 17 | Candriam S.C.A. | 740,000 | 1,406,000 | 1.41% | ||
| 18 | SABBY MANAGEMENT, LLC | 724,500 | 1,377,000 | 1.38% | ||
| 19 | Point72 Asset Management, L.P. | 721,075 | 1,370,000 | 1.37% | ||
| 20 | JPMORGAN CHASE & CO | 659,400 | 1,253,000 | 1.25% | ||
| 21 | HIGHLAND CAPITAL MANAGEMENT LP | 566,609 | 1,077,000 | 1.08% | ||
| 22 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 516,588 | 982,000 | 0.98% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 460,069 | 874,000 | 0.87% | ||
| 24 | SPHERA FUNDS MANAGEMENT LTD. | 428,000 | 813,000 | 0.81% | ||
| 25 | PERKINS CAPITAL MANAGEMENT INC | 427,065 | 811,000 | 0.81% | ||
| 26 | DEERFIELD MANAGEMENT COMPANY, L.P. | 398,499 | 757,000 | 0.76% | ||
| 27 | PERCEPTIVE ADVISORS LLC | 325,000 | 618,000 | 0.62% | ||
| 28 | OXFORD ASSET MANAGEMENT LLP | 317,915 | 605,000 | 0.60% | ||
| 29 | Bank of New York Mellon Corp | 315,009 | 598,000 | 0.60% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 276,674 | 526,000 | 0.53% | ||
| 31 | Weiss Multi-Strategy Advisers LLC | 230,000 | 437,000 | 0.44% | ||
| 32 | BlackRock Investment Management, LLC | 226,545 | 430,000 | 0.43% | ||
| 33 | DEUTSCHE BANK AG\ | 173,079 | 328,000 | 0.33% | ||
| 34 | NOMURA HOLDINGS INC | 160,582 | 303,000 | 0.30% | ||
| 35 | Telemetry Investments, L.L.C. | 155,500 | 295,000 | 0.29% | ||
| 36 | JACOBS LEVY EQUITY MANAGEMENT, INC | 152,771 | 290,000 | 0.29% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 149,678 | 284,000 | 0.28% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 167,000 | 271,000 | 0.27% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 129,500 | 247,000 | 0.25% | ||
| 40 | COWEN INC. | 100,000 | 190,000 | 0.19% | ||
| 41 | TEACHERS ADVISORS, LLC | 98,162 | 187,000 | 0.19% | ||
| 42 | TFS CAPITAL LLC | 84,643 | 161,000 | 0.16% | ||
| 43 | STIFEL FINANCIAL CORP | 83,765 | 159,000 | 0.16% | ||
| 44 | SG Americas Securities, LLC | 76,895 | 146,000 | 0.15% | ||
| 45 | CREDIT SUISSE AG/ | 68,231 | 129,000 | 0.13% | ||
| 46 | VOYA INVESTMENT MANAGEMENT LLC | 61,046 | 116,000 | 0.12% | ||
| 47 | Nationwide Fund Advisors | 60,747 | 115,000 | 0.11% | ||
| 48 | Connor, Clark & Lunn Investment Management Ltd. | 57,300 | 109,000 | 0.11% | ||
| 49 | RHUMBLINE ADVISERS | 57,210 | 109,000 | 0.11% | ||
| 50 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 56,120 | 107,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
