| 1 |
BVF INC/IL |
16,360,538 |
44,828,000 |
28.70% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
6,899,600 |
18,905,000 |
12.10% |
|
|
| 3 |
Avoro Capital Advisors LLC |
5,506,618 |
15,088,000 |
9.66% |
|
|
| 4 |
Redmile Group, LLC |
3,614,990 |
9,905,000 |
6.34% |
|
|
| 5 |
VANGUARD GROUP INC |
3,260,775 |
8,934,000 |
5.72% |
|
|
| 6 |
BlackRock Institutional Trust Company, N.A. |
2,854,314 |
7,821,000 |
5.01% |
|
|
| 7 |
BlackRock Fund Advisors |
2,463,053 |
6,749,000 |
4.32% |
|
|
| 8 |
STATE STREET CORP |
1,582,693 |
4,336,000 |
2.78% |
|
|
| 9 |
Gruss Capital Management LP |
1,106,000 |
3,030,000 |
1.94% |
|
|
| 10 |
Candriam S.C.A. |
1,047,000 |
2,869,000 |
1.84% |
|
|
| 11 |
NORTHERN TRUST CORP |
987,831 |
2,707,000 |
1.73% |
|
|
| 12 |
EcoR1 Capital, LLC |
943,500 |
2,585,000 |
1.65% |
|
|
| 13 |
QVT Financial LP |
614,370 |
1,683,000 |
1.08% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
608,641 |
1,667,000 |
1.07% |
|
|
| 15 |
Broadfin Capital, LLC |
592,200 |
1,623,000 |
1.04% |
|
|
| 16 |
JPMORGAN CHASE & CO |
565,228 |
1,549,000 |
0.99% |
|
|
| 17 |
DEUTSCHE BANK AG\ |
551,871 |
1,510,000 |
0.97% |
|
|
| 18 |
Lombard Odier Asset Management (USA) Corp |
530,286 |
1,453,000 |
0.93% |
|
|
| 19 |
PERCEPTIVE ADVISORS LLC |
3,546,897 |
1,380,000 |
0.88% |
|
|
| 20 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
432,588 |
1,185,000 |
0.76% |
|
|
| 21 |
D. E. Shaw & Co., Inc. |
400,375 |
1,097,000 |
0.70% |
|
|
| 22 |
PERKINS CAPITAL MANAGEMENT INC |
390,650 |
1,070,000 |
0.69% |
|
|
| 23 |
RENAISSANCE TECHNOLOGIES LLC |
339,800 |
931,000 |
0.60% |
|
|
| 24 |
Bank of New York Mellon Corp |
334,498 |
917,000 |
0.59% |
|
|
| 25 |
BlackRock Investment Management, LLC |
325,738 |
893,000 |
0.57% |
|
|
| 26 |
Alyeska Investment Group, L.P. |
316,604 |
867,000 |
0.56% |
|
|
| 27 |
BLACKROCK ADVISORS LLC |
270,975 |
742,000 |
0.48% |
|
|
| 28 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
266,108 |
729,000 |
0.47% |
|
|
| 29 |
Telemetry Investments, L.L.C. |
239,500 |
656,000 |
0.42% |
|
|
| 30 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
177,409 |
487,000 |
0.31% |
|
|
| 31 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
172,739 |
473,000 |
0.30% |
|
|
| 32 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
167,000 |
458,000 |
0.29% |
|
|
| 33 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
164,800 |
452,000 |
0.29% |
Call |
|
| 34 |
MILLENNIUM MANAGEMENT LLC |
158,500 |
434,000 |
0.28% |
|
|
| 35 |
TEACHERS ADVISORS, LLC |
155,140 |
425,000 |
0.27% |
|
|
| 36 |
D.A. DAVIDSON & CO. |
139,058 |
381,000 |
0.24% |
|
|
| 37 |
Connor, Clark & Lunn Investment Management Ltd. |
95,000 |
260,000 |
0.17% |
|
|
| 38 |
RHUMBLINE ADVISERS |
90,817 |
249,000 |
0.16% |
|
|
| 39 |
ClariVest Asset Management LLC |
85,200 |
234,000 |
0.15% |
|
|
| 40 |
NEW YORK STATE COMMON RETIREMENT FUND |
84,200 |
231,000 |
0.15% |
|
|
| 41 |
STIFEL FINANCIAL CORP |
83,765 |
230,000 |
0.15% |
|
|
| 42 |
TFS CAPITAL LLC |
83,394 |
228,000 |
0.15% |
|
|
| 43 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
77,836 |
213,000 |
0.14% |
|
|
| 44 |
METROPOLITAN LIFE INSURANCE CO/NY |
73,943 |
203,000 |
0.13% |
|
|
| 45 |
ALLIANCEBERNSTEIN L.P. |
73,100 |
200,000 |
0.13% |
|
|
| 46 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
68,335 |
187,000 |
0.12% |
|
|
| 47 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
66,601 |
182,000 |
0.12% |
|
|
| 48 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
64,050 |
176,000 |
0.11% |
|
|
| 49 |
Nationwide Fund Advisors |
63,545 |
174,000 |
0.11% |
|
|
| 50 |
AMERICAN INTERNATIONAL GROUP, INC. |
60,021 |
164,000 |
0.10% |
|
|
