| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 14,314,178 | 23,332,000 | 22.53% | ||
| 2 | FRANKLIN RESOURCES INC | 7,450,300 | 12,144,000 | 11.72% | ||
| 3 | Avoro Capital Advisors LLC | 4,491,636 | 7,321,000 | 7.07% | ||
| 4 | QVT Financial LP | 4,321,764 | 7,044,000 | 6.80% | ||
| 5 | Broadfin Capital, LLC | 3,500,000 | 5,705,000 | 5.51% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 3,487,220 | 5,684,000 | 5.49% | ||
| 7 | VANGUARD GROUP INC | 3,001,360 | 4,892,000 | 4.72% | ||
| 8 | BlackRock Fund Advisors | 2,612,571 | 4,258,000 | 4.11% | ||
| 9 | First Eagle Investment Management, LLC | 1,300,000 | 2,119,000 | 2.05% | ||
| 10 | D. E. Shaw & Co., Inc. | 1,179,145 | 1,922,000 | 1.86% | ||
| 11 | RA CAPITAL MANAGEMENT, L.P. | 1,165,765 | 1,900,000 | 1.83% | ||
| 12 | Gruss Capital Management LP | 1,106,000 | 1,803,000 | 1.74% | ||
| 13 | STATE STREET CORP | 968,216 | 1,579,000 | 1.52% | ||
| 14 | PERCEPTIVE ADVISORS LLC | 925,000 | 1,508,000 | 1.46% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 912,480 | 1,487,000 | 1.44% | ||
| 16 | NORTHERN TRUST CORP | 881,366 | 1,437,000 | 1.39% | ||
| 17 | HIGHLAND CAPITAL MANAGEMENT LP | 817,341 | 1,332,000 | 1.29% | ||
| 18 | Alyeska Investment Group, L.P. | 750,000 | 1,223,000 | 1.18% | ||
| 19 | Candriam S.C.A. | 740,000 | 1,206,000 | 1.16% | ||
| 20 | Point72 Asset Management, L.P. | 625,000 | 1,019,000 | 0.98% | ||
| 21 | RENAISSANCE TECHNOLOGIES LLC | 614,178 | 1,001,000 | 0.97% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 576,077 | 939,000 | 0.91% | ||
| 23 | JPMORGAN CHASE & CO | 566,300 | 923,000 | 0.89% | ||
| 24 | JACOBS LEVY EQUITY MANAGEMENT, INC | 536,971 | 875,000 | 0.84% | ||
| 25 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 516,588 | 842,000 | 0.81% | ||
| 26 | TFS CAPITAL LLC | 501,801 | 818,000 | 0.79% | ||
| 27 | DEUTSCHE BANK AG\ | 489,405 | 796,000 | 0.77% | ||
| 28 | PERKINS CAPITAL MANAGEMENT INC | 427,600 | 697,000 | 0.67% | ||
| 29 | SABBY MANAGEMENT, LLC | 417,952 | 681,000 | 0.66% | ||
| 30 | Bank of New York Mellon Corp | 333,662 | 544,000 | 0.53% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 276,674 | 451,000 | 0.44% | ||
| 32 | BlackRock Investment Management, LLC | 274,283 | 447,000 | 0.43% | ||
| 33 | BLACKROCK ADVISORS LLC | 257,735 | 420,000 | 0.41% | ||
| 34 | Telemetry Investments, L.L.C. | 250,000 | 408,000 | 0.39% | ||
| 35 | Ayer Capital Management, LP | 250,000 | 407,000 | 0.39% | ||
| 36 | Weiss Multi-Strategy Advisers LLC | 213,500 | 348,000 | 0.34% | ||
| 37 | MONASHEE INVESTMENT MANAGEMENT LLC | 200,000 | 326,000 | 0.31% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 171,778 | 280,000 | 0.27% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 167,000 | 271,000 | 0.26% | ||
| 40 | DEERFIELD MANAGEMENT COMPANY, L.P. | 143,200 | 233,000 | 0.22% | ||
| 41 | TEACHERS ADVISORS, LLC | 130,421 | 213,000 | 0.21% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 129,500 | 212,000 | 0.20% | ||
| 43 | COWEN INC. | 100,000 | 163,000 | 0.16% | ||
| 44 | ZACKS INVESTMENT MANAGEMENT | 98,545 | 161,000 | 0.16% | ||
| 45 | Nine Chapters Capital Management LLC | 93,900 | 153,000 | 0.15% | ||
| 46 | STIFEL FINANCIAL CORP | 83,765 | 137,000 | 0.13% | ||
| 47 | RHUMBLINE ADVISERS | 80,560 | 131,000 | 0.13% | ||
| 48 | Connor, Clark & Lunn Investment Management Ltd. | 74,300 | 121,000 | 0.12% | ||
| 49 | MORGAN STANLEY | 67,912 | 111,000 | 0.11% | ||
| 50 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 65,344 | 106,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
