| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 9,858,278 | 31,941,000 | 24.08% | ||
| 2 | QVT Financial LP | 5,628,899 | 18,238,000 | 13.75% | ||
| 3 | FRANKLIN RESOURCES INC | 4,476,600 | 14,504,000 | 10.93% | ||
| 4 | BlackRock Institutional Trust Company, N.A. | 2,826,828 | 9,159,000 | 6.91% | ||
| 5 | First Eagle Investment Management, LLC | 2,384,039 | 7,724,000 | 5.82% | ||
| 6 | VANGUARD GROUP INC | 1,915,113 | 6,205,000 | 4.68% | ||
| 7 | BlackRock Fund Advisors | 1,770,950 | 5,738,000 | 4.33% | ||
| 8 | D. E. Shaw & Co., Inc. | 991,900 | 3,214,000 | 2.42% | ||
| 9 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 950,000 | 3,078,000 | 2.32% | ||
| 10 | Employees Retirement System of Texas | 891,000 | 2,887,000 | 2.18% | ||
| 11 | GREAT POINT PARTNERS LLC | 791,800 | 2,565,000 | 1.93% | ||
| 12 | SPHERA FUNDS MANAGEMENT LTD. | 738,336 | 2,392,000 | 1.80% | ||
| 13 | STATE STREET CORP | 658,171 | 2,132,000 | 1.61% | ||
| 14 | DRIEHAUS CAPITAL MANAGEMENT LLC | 626,473 | 2,030,000 | 1.53% | ||
| 15 | PERKINS CAPITAL MANAGEMENT INC | 481,100 | 1,559,000 | 1.18% | ||
| 16 | FMR LLC | 343,600 | 1,113,000 | 0.84% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 333,857 | 1,081,000 | 0.81% | ||
| 18 | DEUTSCHE BANK AG\ | 308,516 | 998,000 | 0.75% | ||
| 19 | Bank of New York Mellon Corp | 299,235 | 970,000 | 0.73% | ||
| 20 | PERCEPTIVE ADVISORS LLC | 292,779 | 949,000 | 0.72% | ||
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 265,109 | 859,000 | 0.65% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 240,700 | 780,000 | 0.59% | Call | |
| 23 | MILLENNIUM MANAGEMENT LLC | 236,665 | 767,000 | 0.58% | ||
| 24 | TFS CAPITAL LLC | 235,081 | 762,000 | 0.57% | ||
| 25 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 227,988 | 739,000 | 0.56% | ||
| 26 | BlackRock Investment Management, LLC | 199,186 | 645,000 | 0.49% | ||
| 27 | JANE STREET GROUP, LLC | 198,565 | 644,000 | 0.49% | ||
| 28 | Allianz Asset Management GmbH | 181,550 | 588,000 | 0.44% | ||
| 29 | NORTHERN TRUST CORP | 180,266 | 584,000 | 0.44% | ||
| 30 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 167,000 | 541,000 | 0.41% | ||
| 31 | MORGAN STANLEY | 160,214 | 519,000 | 0.39% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 155,031 | 502,000 | 0.38% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 129,500 | 420,000 | 0.32% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 129,200 | 419,000 | 0.32% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 101,100 | 328,000 | 0.25% | Put | |
| 36 | Weiss Multi-Strategy Advisers LLC | 100,000 | 324,000 | 0.24% | ||
| 37 | TEACHERS ADVISORS, LLC | 98,162 | 318,000 | 0.24% | ||
| 38 | SG Americas Securities, LLC | 97,520 | 316,000 | 0.24% | ||
| 39 | A.R.T. Advisors, LLC | 79,374 | 257,000 | 0.19% | ||
| 40 | NOMURA HOLDINGS INC | 72,161 | 230,000 | 0.17% | ||
| 41 | VOYA INVESTMENT MANAGEMENT LLC | 61,046 | 198,000 | 0.15% | ||
| 42 | METROPOLITAN LIFE INSURANCE CO/NY | 58,322 | 189,000 | 0.14% | ||
| 43 | RHUMBLINE ADVISERS | 54,410 | 176,000 | 0.13% | ||
| 44 | Nationwide Fund Advisors | 52,804 | 171,000 | 0.13% | ||
| 45 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 49,896 | 162,000 | 0.12% | ||
| 46 | NOMURA HOLDINGS INC | 50,000 | 160,000 | 0.12% | Call | |
| 47 | CREDIT SUISSE AG/ | 48,204 | 156,000 | 0.12% | ||
| 48 | BLACKROCK ADVISORS LLC | 47,697 | 155,000 | 0.12% | ||
| 49 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 47,526 | 154,000 | 0.12% | ||
| 50 | GROUP ONE TRADING LLC | 47,159 | 153,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
