| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 9,754,178 | 36,481,000 | 16.95% | ||
| 2 | FRANKLIN RESOURCES INC | 7,555,500 | 28,258,000 | 13.13% | ||
| 3 | Avoro Capital Advisors LLC | 5,617,003 | 21,008,000 | 9.76% | ||
| 4 | Redmile Group, LLC | 4,164,878 | 15,577,000 | 7.24% | ||
| 5 | BlackRock Institutional Trust Company, N.A. | 3,487,848 | 13,045,000 | 6.06% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 3,346,897 | 12,517,000 | 5.81% | ||
| 7 | VANGUARD GROUP INC | 3,173,902 | 11,871,000 | 5.51% | ||
| 8 | BlackRock Fund Advisors | 2,625,131 | 9,818,000 | 4.56% | ||
| 9 | Broadfin Capital, LLC | 1,700,000 | 6,358,000 | 2.95% | ||
| 10 | STATE STREET CORP | 1,408,549 | 5,266,000 | 2.45% | ||
| 11 | Gruss Capital Management LP | 1,106,000 | 4,136,000 | 1.92% | ||
| 12 | NORTHERN TRUST CORP | 973,667 | 3,642,000 | 1.69% | ||
| 13 | ACUTA CAPITAL PARTNERS, LLC | 670,000 | 2,506,000 | 1.16% | ||
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 602,834 | 2,254,000 | 1.05% | ||
| 15 | JPMORGAN CHASE & CO | 574,292 | 2,148,000 | 1.00% | ||
| 16 | D. E. Shaw & Co., Inc. | 545,089 | 2,039,000 | 0.95% | ||
| 17 | DEUTSCHE BANK AG\ | 532,785 | 1,990,000 | 0.92% | ||
| 18 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 516,588 | 1,932,000 | 0.90% | ||
| 19 | RENAISSANCE TECHNOLOGIES LLC | 474,192 | 1,773,000 | 0.82% | ||
| 20 | QVT Financial LP | 466,746 | 1,746,000 | 0.81% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 455,800 | 1,705,000 | 0.79% | Call | |
| 22 | Bank of New York Mellon Corp | 410,219 | 1,534,000 | 0.71% | ||
| 23 | PERKINS CAPITAL MANAGEMENT INC | 404,413 | 1,513,000 | 0.70% | ||
| 24 | MILLENNIUM MANAGEMENT LLC | 369,579 | 1,382,000 | 0.64% | ||
| 25 | BlackRock Investment Management, LLC | 359,836 | 1,346,000 | 0.63% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 305,088 | 1,141,000 | 0.53% | ||
| 27 | Lombard Odier Asset Management (USA) Corp | 300,000 | 1,122,000 | 0.52% | ||
| 28 | Alyeska Investment Group, L.P. | 300,127 | 1,122,000 | 0.52% | ||
| 29 | BLACKROCK ADVISORS LLC | 295,074 | 1,104,000 | 0.51% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 282,000 | 1,055,000 | 0.49% | Put | |
| 31 | Telemetry Investments, L.L.C. | 275,000 | 1,028,000 | 0.48% | ||
| 32 | JACOBS LEVY EQUITY MANAGEMENT, INC | 269,713 | 1,009,000 | 0.47% | ||
| 33 | Ayer Capital Management, LP | 250,000 | 935,000 | 0.43% | ||
| 34 | MORGAN STANLEY | 235,795 | 882,000 | 0.41% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 186,839 | 699,000 | 0.32% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 177,409 | 664,000 | 0.31% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 167,000 | 625,000 | 0.29% | ||
| 38 | TEACHERS ADVISORS, LLC | 148,309 | 555,000 | 0.26% | ||
| 39 | TFS CAPITAL LLC | 147,690 | 552,000 | 0.26% | ||
| 40 | D.A. DAVIDSON & CO. | 147,114 | 550,000 | 0.26% | ||
| 41 | CITADEL ADVISORS LLC | 139,804 | 523,000 | 0.24% | ||
| 42 | NOMURA HOLDINGS INC | 138,900 | 522,000 | 0.24% | ||
| 43 | Numeric Investors LLC | 132,100 | 494,000 | 0.23% | ||
| 44 | GROUP ONE TRADING LLC | 117,388 | 439,000 | 0.20% | ||
| 45 | Virtu KCG Holdings LLC | 101,306 | 379,000 | 0.18% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 101,311 | 379,000 | 0.18% | ||
| 47 | PEAK6 Group LLC | 97,900 | 366,000 | 0.17% | Call | |
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 90,788 | 340,000 | 0.16% | ||
| 49 | RHUMBLINE ADVISERS | 87,170 | 326,000 | 0.15% | ||
| 50 | ClariVest Asset Management LLC | 84,700 | 316,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
