| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 18,799,368 | 41,735,000 | 31.53% | ||
| 2 | FRANKLIN RESOURCES INC | 6,899,600 | 15,317,000 | 11.57% | ||
| 3 | Avoro Capital Advisors LLC | 4,119,072 | 9,144,000 | 6.91% | ||
| 4 | BlackRock Fund Advisors | 3,677,039 | 8,163,000 | 6.17% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 3,414,121 | 7,579,000 | 5.73% | ||
| 6 | VANGUARD GROUP INC | 3,283,981 | 7,291,000 | 5.51% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 2,787,225 | 6,188,000 | 4.67% | ||
| 8 | Redmile Group, LLC | 2,331,300 | 5,175,000 | 3.91% | ||
| 9 | STATE STREET CORP | 1,619,864 | 3,598,000 | 2.72% | ||
| 10 | Gruss Capital Management LP | 1,106,000 | 2,455,000 | 1.85% | ||
| 11 | NORTHERN TRUST CORP | 1,023,837 | 2,273,000 | 1.72% | ||
| 12 | Anson Funds Management LP | 827,203 | 1,836,000 | 1.39% | ||
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 623,020 | 1,383,000 | 1.04% | ||
| 14 | DRW Securities, LLC | 511,672 | 1,136,000 | 0.86% | ||
| 15 | JPMORGAN CHASE & CO | 486,092 | 1,079,000 | 0.82% | ||
| 16 | DEUTSCHE BANK AG\ | 459,508 | 1,018,000 | 0.77% | ||
| 17 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 432,588 | 960,000 | 0.73% | ||
| 18 | A.R.T. Advisors, LLC | 389,593 | 864,000 | 0.65% | ||
| 19 | PERKINS CAPITAL MANAGEMENT INC | 381,350 | 847,000 | 0.64% | ||
| 20 | BlackRock Investment Management, LLC | 328,447 | 729,000 | 0.55% | ||
| 21 | D. E. Shaw & Co., Inc. | 325,330 | 722,000 | 0.55% | ||
| 22 | Bank of New York Mellon Corp | 325,593 | 722,000 | 0.55% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 316,197 | 702,000 | 0.53% | ||
| 24 | FT OPTIONS LLC | 300,011 | 666,000 | 0.50% | ||
| 25 | First Eagle Investment Management, LLC | 300,000 | 666,000 | 0.50% | ||
| 26 | Telemetry Investments, L.L.C. | 300,000 | 666,000 | 0.50% | ||
| 27 | BLACKROCK ADVISORS LLC | 241,678 | 537,000 | 0.41% | ||
| 28 | CITADEL ADVISORS LLC | 224,214 | 498,000 | 0.38% | ||
| 29 | NEXTHERA CAPITAL LP | 200,000 | 444,000 | 0.34% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 195,576 | 434,000 | 0.33% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 177,409 | 394,000 | 0.30% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 175,839 | 390,000 | 0.29% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 167,000 | 371,000 | 0.28% | ||
| 34 | TEACHERS ADVISORS, LLC | 155,140 | 344,000 | 0.26% | ||
| 35 | MILLENNIUM MANAGEMENT LLC | 131,703 | 292,000 | 0.22% | ||
| 36 | Virtu KCG Holdings LLC | 124,367 | 276,000 | 0.21% | ||
| 37 | VIRTUS ETF ADVISERS LLC | 123,925 | 275,000 | 0.21% | ||
| 38 | COWEN INC. | 114,200 | 254,000 | 0.19% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 105,400 | 234,000 | 0.18% | Call | |
| 40 | OXFORD ASSET MANAGEMENT LLP | 98,976 | 230,000 | 0.17% | ||
| 41 | ClariVest Asset Management LLC | 101,800 | 226,000 | 0.17% | ||
| 42 | RHUMBLINE ADVISERS | 98,277 | 218,000 | 0.16% | ||
| 43 | Connor, Clark & Lunn Investment Management Ltd. | 95,000 | 211,000 | 0.16% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 73,100 | 200,000 | 0.15% | ||
| 45 | ProShare Advisors LLC | 90,153 | 200,000 | 0.15% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 84,200 | 187,000 | 0.14% | ||
| 47 | STIFEL FINANCIAL CORP | 83,765 | 186,000 | 0.14% | ||
| 48 | AQR CAPITAL MANAGEMENT LLC | 76,612 | 170,000 | 0.13% | ||
| 49 | MORGAN STANLEY | 75,913 | 168,000 | 0.13% | ||
| 50 | METROPOLITAN LIFE INSURANCE CO/NY | 73,943 | 164,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
