| 1 |
Essex Woodlands Management, Inc. |
4,861,111 |
20,028,000 |
37.19% |
|
|
| 2 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
3,381,439 |
13,932,000 |
25.87% |
|
|
| 3 |
Opaleye Management Inc. |
2,120,000 |
8,734,000 |
16.22% |
|
|
| 4 |
PERKINS CAPITAL MANAGEMENT INC |
662,700 |
2,730,000 |
5.07% |
|
|
| 5 |
VANGUARD GROUP INC |
354,163 |
1,459,000 |
2.71% |
|
|
| 6 |
Informed Momentum Co LLC |
328,440 |
1,353,000 |
2.51% |
|
|
| 7 |
DEUTSCHE BANK AG\ |
254,071 |
1,046,000 |
1.94% |
|
|
| 8 |
Consonance Capital Management LP |
224,400 |
925,000 |
1.72% |
|
|
| 9 |
Fiduciary Trust Co International of Pennsylvania |
177,248 |
730,000 |
1.36% |
|
|
| 10 |
Virtu KCG Holdings LLC |
94,804 |
391,000 |
0.73% |
|
|
| 11 |
GOLDMAN SACHS GROUP INC |
93,081 |
383,000 |
0.71% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
92,026 |
379,000 |
0.70% |
|
|
| 13 |
RENAISSANCE TECHNOLOGIES LLC |
78,500 |
323,000 |
0.60% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
70,258 |
289,000 |
0.54% |
|
|
| 15 |
TFS CAPITAL LLC |
38,051 |
157,000 |
0.29% |
|
|
| 16 |
NORTHERN TRUST CORP |
31,173 |
128,000 |
0.24% |
|
|
| 17 |
Bank of New York Mellon Corp |
27,153 |
112,000 |
0.21% |
|
|
| 18 |
Spectrum Asset Management, Inc. (NB/CA) |
25,000 |
103,000 |
0.19% |
|
|
| 19 |
Spark Investment Management LLC |
23,500 |
96,000 |
0.18% |
|
|
| 20 |
Commonwealth Equity Services, Inc |
19,036 |
78,000 |
0.14% |
|
|
| 21 |
Rotella Capital Management, Inc. |
16,978 |
70,000 |
0.13% |
|
|
| 22 |
BANK OF AMERICA CORP /DE/ |
16,888 |
69,000 |
0.13% |
|
|
| 23 |
AMG National Trust Bank |
15,965 |
66,000 |
0.12% |
|
|
| 24 |
VSR Financial Services, Inc. |
15,000 |
62,000 |
0.12% |
|
|
| 25 |
MORGAN STANLEY |
8,905 |
37,000 |
0.07% |
|
|
| 26 |
UBS Group AG |
8,500 |
35,000 |
0.07% |
|
|
| 27 |
REILLY FINANCIAL ADVISORS, LLC |
8,000 |
33,000 |
0.06% |
|
|
| 28 |
JNBA Financial Advisors |
7,775 |
32,000 |
0.06% |
|
|
| 29 |
Walleye Trading LLC |
5,700 |
23,000 |
0.04% |
|
|
| 30 |
BlackRock Investment Management, LLC |
3,654 |
15,000 |
0.03% |
|
|
| 31 |
FIFTH THIRD BANCORP |
3,300 |
14,000 |
0.03% |
|
|
| 32 |
Tower Research Capital LLC (TRC) |
1,521 |
6,000 |
0.01% |
|
|
| 33 |
MAGEE THOMSON INVESTMENT PARTNERS LLC |
1,205 |
5,000 |
0.01% |
|
|
| 34 |
ROYAL BANK OF CANADA |
463 |
2,000 |
0.00% |
|
|
| 35 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
311 |
1,000 |
0.00% |
|
|
| 36 |
WELLS FARGO & COMPANY/MN |
2 |
0 |
0.00% |
|
|
| 37 |
ROBLE, BELKO & COMPANY, INC |
100 |
0 |
0.00% |
|
|
