| 1 |
Essex Woodlands Management, Inc. |
4,861,111 |
26,056,000 |
31.44% |
|
|
| 2 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
3,381,439 |
18,125,000 |
21.87% |
|
|
| 3 |
Opaleye Management Inc. |
2,120,000 |
11,363,000 |
13.71% |
|
|
| 4 |
Cortina Asset Management, LLC |
935,222 |
5,013,000 |
6.05% |
|
|
| 5 |
PERKINS CAPITAL MANAGEMENT INC |
633,133 |
3,394,000 |
4.10% |
|
|
| 6 |
VANGUARD GROUP INC |
480,154 |
2,573,000 |
3.10% |
|
|
| 7 |
Consonance Capital Management LP |
406,351 |
2,178,000 |
2.63% |
|
|
| 8 |
Informed Momentum Co LLC |
318,478 |
1,707,000 |
2.06% |
|
|
| 9 |
GFS Advisors, LLC |
9,112 |
1,700,000 |
2.05% |
|
|
| 10 |
USCA RIA LLC |
9,112 |
1,700,000 |
2.05% |
|
|
| 11 |
DEUTSCHE BANK AG\ |
193,475 |
1,036,000 |
1.25% |
|
|
| 12 |
Fiduciary Trust Co International of Pennsylvania |
188,498 |
1,010,000 |
1.22% |
|
|
| 13 |
STRS OHIO |
179,042 |
959,000 |
1.16% |
|
|
| 14 |
PROFICIO CAPITAL PARTNERS LLC |
146,266 |
784,000 |
0.95% |
|
|
| 15 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
131,716 |
706,000 |
0.85% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
110,353 |
591,000 |
0.71% |
|
|
| 17 |
UBS Group AG |
97,946 |
525,000 |
0.63% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
80,749 |
433,000 |
0.52% |
|
|
| 19 |
BlackRock Fund Advisors |
55,184 |
296,000 |
0.36% |
|
|
| 20 |
GOLDMAN SACHS GROUP INC |
47,492 |
255,000 |
0.31% |
|
|
| 21 |
MILLENNIUM MANAGEMENT LLC |
42,399 |
227,000 |
0.27% |
|
|
| 22 |
CREDIT SUISSE AG/ |
39,437 |
212,000 |
0.26% |
|
|
| 23 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
37,651 |
202,000 |
0.24% |
|
|
| 24 |
NORTHERN TRUST CORP |
31,173 |
167,000 |
0.20% |
|
|
| 25 |
LPL Financial LLC |
32,236 |
166,000 |
0.20% |
|
|
| 26 |
Bank of New York Mellon Corp |
27,153 |
146,000 |
0.18% |
|
|
| 27 |
Segantii Capital Management Ltd |
27,142 |
146,000 |
0.18% |
|
|
| 28 |
MORGAN STANLEY |
23,513 |
126,000 |
0.15% |
|
|
| 29 |
Spectrum Asset Management, Inc. (NB/CA) |
20,000 |
107,000 |
0.13% |
|
|
| 30 |
Commonwealth Equity Services, Inc |
17,711 |
95,000 |
0.11% |
|
|
| 31 |
AMG National Trust Bank |
15,965 |
86,000 |
0.10% |
|
|
| 32 |
BlueCrest Capital Management Ltd |
14,390 |
77,000 |
0.09% |
|
|
| 33 |
STIFEL FINANCIAL CORP |
13,800 |
74,000 |
0.09% |
|
|
| 34 |
NOMURA HOLDINGS INC |
13,463 |
72,000 |
0.09% |
|
|
| 35 |
SEI INVESTMENTS CO |
13,328 |
71,000 |
0.09% |
|
|
| 36 |
Verition Fund Management LLC |
12,569 |
67,000 |
0.08% |
|
|
| 37 |
SG Americas Securities, LLC |
10,600 |
57,000 |
0.07% |
|
|
| 38 |
Alpine Global Management, LLC |
10,088 |
54,000 |
0.07% |
|
|
| 39 |
Geneva Advisors, LLC |
10,000 |
54,000 |
0.07% |
|
|
| 40 |
BANK OF AMERICA CORP /DE/ |
9,521 |
51,000 |
0.06% |
|
|
| 41 |
REILLY FINANCIAL ADVISORS, LLC |
8,000 |
43,000 |
0.05% |
|
|
| 42 |
JNBA Financial Advisors |
7,775 |
42,000 |
0.05% |
|
|
| 43 |
PRELUDE CAPITAL MANAGEMENT, LLC |
4,400 |
24,000 |
0.03% |
|
|
| 44 |
Financial Architects, Inc |
4,000 |
21,000 |
0.03% |
|
|
| 45 |
BlackRock Investment Management, LLC |
3,542 |
19,000 |
0.02% |
|
|
| 46 |
FIFTH THIRD BANCORP |
3,300 |
18,000 |
0.02% |
|
|
| 47 |
Tower Research Capital LLC (TRC) |
1,785 |
9,000 |
0.01% |
|
|
| 48 |
BLACKROCK ADVISORS LLC |
1,640 |
9,000 |
0.01% |
|
|
| 49 |
Walleye Trading LLC |
1,200 |
6,000 |
0.01% |
|
|
| 50 |
BARCLAYS PLC |
900 |
5,000 |
0.01% |
|
|
