| 1 |
Essex Woodlands Management, Inc. |
4,861,111 |
24,306,000 |
34.58% |
|
|
| 2 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
3,381,439 |
16,907,000 |
24.05% |
|
|
| 3 |
Opaleye Management Inc. |
2,120,000 |
10,600,000 |
15.08% |
|
|
| 4 |
PERKINS CAPITAL MANAGEMENT INC |
643,758 |
3,219,000 |
4.58% |
|
|
| 5 |
VANGUARD GROUP INC |
414,645 |
2,073,000 |
2.95% |
|
|
| 6 |
Consonance Capital Management LP |
406,351 |
2,032,000 |
2.89% |
|
|
| 7 |
Informed Momentum Co LLC |
329,738 |
1,649,000 |
2.35% |
|
|
| 8 |
Cortina Asset Management, LLC |
282,089 |
1,410,000 |
2.01% |
|
|
| 9 |
Fiduciary Trust Co International of Pennsylvania |
188,498 |
942,000 |
1.34% |
|
|
| 10 |
DEUTSCHE BANK AG\ |
185,011 |
924,000 |
1.31% |
|
|
| 11 |
STRS OHIO |
179,042 |
895,000 |
1.27% |
|
|
| 12 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
152,201 |
761,000 |
1.08% |
|
|
| 13 |
PROFICIO CAPITAL PARTNERS LLC |
146,266 |
731,000 |
1.04% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
110,418 |
552,000 |
0.79% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
80,749 |
404,000 |
0.57% |
|
|
| 16 |
PRICE T ROWE ASSOCIATES INC /MD/ |
75,914 |
380,000 |
0.54% |
|
|
| 17 |
BlackRock Fund Advisors |
59,329 |
297,000 |
0.42% |
|
|
| 18 |
WELLS FARGO & COMPANY/MN |
44,761 |
224,000 |
0.32% |
|
|
| 19 |
RENAISSANCE TECHNOLOGIES LLC |
36,400 |
182,000 |
0.26% |
|
|
| 20 |
TFS CAPITAL LLC |
32,920 |
165,000 |
0.23% |
|
|
| 21 |
GOLDMAN SACHS GROUP INC |
31,350 |
157,000 |
0.22% |
|
|
| 22 |
NORTHERN TRUST CORP |
31,173 |
156,000 |
0.22% |
|
|
| 23 |
Bank of New York Mellon Corp |
27,153 |
136,000 |
0.19% |
|
|
| 24 |
AlpInvest Partners B.V. |
25,309 |
127,000 |
0.18% |
|
|
| 25 |
Spectrum Asset Management, Inc. (NB/CA) |
25,000 |
125,000 |
0.18% |
|
|
| 26 |
Rotella Capital Management, Inc. |
17,970 |
90,000 |
0.13% |
|
|
| 27 |
Commonwealth Equity Services, Inc |
17,711 |
89,000 |
0.13% |
|
|
| 28 |
MORGAN STANLEY |
16,913 |
84,000 |
0.12% |
|
|
| 29 |
AMG National Trust Bank |
15,965 |
80,000 |
0.11% |
|
|
| 30 |
VSR Financial Services, Inc. |
15,000 |
75,000 |
0.11% |
|
|
| 31 |
HARBOURVEST PARTNERS LLC |
13,964 |
70,000 |
0.10% |
|
|
| 32 |
Walleye Trading LLC |
13,500 |
68,000 |
0.10% |
|
|
| 33 |
SEI INVESTMENTS CO |
13,328 |
67,000 |
0.10% |
|
|
| 34 |
BANK OF AMERICA CORP /DE/ |
11,521 |
58,000 |
0.08% |
|
|
| 35 |
LPL Financial LLC |
10,562 |
53,000 |
0.08% |
|
|
| 36 |
UBS Group AG |
8,972 |
45,000 |
0.06% |
|
|
| 37 |
REILLY FINANCIAL ADVISORS, LLC |
8,000 |
40,000 |
0.06% |
|
|
| 38 |
JNBA Financial Advisors |
7,775 |
39,000 |
0.06% |
|
|
| 39 |
BlackRock Investment Management, LLC |
3,923 |
20,000 |
0.03% |
|
|
| 40 |
PRELUDE CAPITAL MANAGEMENT, LLC |
3,675 |
18,000 |
0.03% |
|
|
| 41 |
FIFTH THIRD BANCORP |
3,300 |
17,000 |
0.02% |
|
|
| 42 |
BLACKROCK ADVISORS LLC |
1,640 |
8,000 |
0.01% |
|
|
| 43 |
Tower Research Capital LLC (TRC) |
1,522 |
7,000 |
0.01% |
|
|
| 44 |
AMERICAN INTERNATIONAL GROUP, INC. |
1,000 |
5,000 |
0.01% |
|
|
| 45 |
MAGEE THOMSON INVESTMENT PARTNERS LLC |
854 |
4,000 |
0.01% |
|
|
| 46 |
MSI Financial Services Inc |
500 |
3,000 |
0.00% |
|
|
| 47 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
311 |
2,000 |
0.00% |
|
|
| 48 |
ROYAL BANK OF CANADA |
463 |
2,000 |
0.00% |
|
|
| 49 |
ROBLE, BELKO & COMPANY, INC |
100 |
1,000 |
0.00% |
|
|
