| 1 |
Essex Woodlands Management, Inc. |
4,861,111 |
43,896,000 |
28.28% |
|
|
| 2 |
Opaleye Management Inc. |
2,000,000 |
18,060,000 |
11.64% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,893,030 |
17,094,000 |
11.01% |
|
|
| 4 |
VANGUARD GROUP INC |
994,144 |
8,977,000 |
5.78% |
|
|
| 5 |
BlackRock Fund Advisors |
680,329 |
6,143,000 |
3.96% |
|
|
| 6 |
PERKINS CAPITAL MANAGEMENT INC |
620,908 |
5,607,000 |
3.61% |
|
|
| 7 |
Cortina Asset Management, LLC |
614,600 |
5,550,000 |
3.58% |
|
|
| 8 |
NEXT CENTURY GROWTH INVESTORS LLC |
544,456 |
4,916,000 |
3.17% |
|
|
| 9 |
Informed Momentum Co LLC |
371,477 |
3,354,000 |
2.16% |
|
|
| 10 |
STATE STREET CORP |
312,772 |
2,825,000 |
1.82% |
|
|
| 11 |
BlackRock Institutional Trust Company, N.A. |
303,249 |
2,738,000 |
1.76% |
|
|
| 12 |
Allianz Asset Management GmbH |
301,185 |
2,720,000 |
1.75% |
|
|
| 13 |
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC |
263,158 |
2,376,000 |
1.53% |
|
|
| 14 |
NORTHERN TRUST CORP |
263,053 |
2,375,000 |
1.53% |
|
|
| 15 |
DEUTSCHE BANK AG\ |
231,713 |
2,091,000 |
1.35% |
|
|
| 16 |
G2 Investment Partners Management LLC |
227,292 |
2,052,000 |
1.32% |
|
|
| 17 |
WADDELL & REED FINANCIAL INC |
199,288 |
1,799,000 |
1.16% |
|
|
| 18 |
ANALYTIC INVESTORS, LLC |
195,325 |
1,763,000 |
1.14% |
|
|
| 19 |
EMERALD ACQUISITION LTD. |
195,124 |
1,762,000 |
1.14% |
|
|
| 20 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
180,000 |
1,625,000 |
1.05% |
|
|
| 21 |
Timpani Capital Management LLC |
165,784 |
1,497,000 |
0.96% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
165,595 |
1,495,000 |
0.96% |
|
|
| 23 |
Fiduciary Trust Co International of Pennsylvania |
131,365 |
1,186,000 |
0.76% |
|
|
| 24 |
RENAISSANCE TECHNOLOGIES LLC |
126,900 |
1,146,000 |
0.74% |
|
|
| 25 |
COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT |
110,521 |
998,000 |
0.64% |
|
|
| 26 |
TWO SIGMA INVESTMENTS, LP |
89,888 |
812,000 |
0.52% |
|
|
| 27 |
BlackRock Investment Management, LLC |
89,509 |
808,000 |
0.52% |
|
|
| 28 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
88,823 |
802,000 |
0.52% |
|
|
| 29 |
PROFICIO CAPITAL PARTNERS LLC |
87,200 |
787,000 |
0.51% |
|
|
| 30 |
MENTA CAPITAL LLC |
86,008 |
777,000 |
0.50% |
|
|
| 31 |
Bank of New York Mellon Corp |
81,760 |
738,000 |
0.48% |
|
|
| 32 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
70,880 |
640,000 |
0.41% |
|
|
| 33 |
Granite Point Capital Management, L.P. |
67,000 |
605,000 |
0.39% |
|
|
| 34 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
50,993 |
460,000 |
0.30% |
|
|
| 35 |
TEACHERS ADVISORS, LLC |
38,847 |
351,000 |
0.23% |
|
|
| 36 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
38,300 |
346,000 |
0.22% |
|
|
| 37 |
Millrace Asset Group, Inc. |
34,000 |
307,000 |
0.20% |
|
|
| 38 |
TWO SIGMA ADVISERS, LP |
26,900 |
243,000 |
0.16% |
|
|
| 39 |
NEW YORK STATE COMMON RETIREMENT FUND |
24,800 |
224,000 |
0.14% |
|
|
| 40 |
RHUMBLINE ADVISERS |
24,410 |
220,000 |
0.14% |
|
|
| 41 |
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
21,335 |
193,000 |
0.12% |
|
|
| 42 |
SYMMETRY PEAK MANAGEMENT LLC |
20,000 |
181,000 |
0.12% |
Call |
|
| 43 |
ROYCE & ASSOCIATES LP |
20,000 |
181,000 |
0.12% |
|
|
| 44 |
Trellus Management Company, LLC |
18,906 |
171,000 |
0.11% |
|
|
| 45 |
MORGAN STANLEY |
18,747 |
169,000 |
0.11% |
|
|
| 46 |
VOYA INVESTMENT MANAGEMENT LLC |
18,534 |
167,000 |
0.11% |
|
|
| 47 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
18,368 |
165,000 |
0.11% |
|
|
| 48 |
Commonwealth Equity Services, Inc |
17,711 |
160,000 |
0.10% |
|
|
| 49 |
METROPOLITAN LIFE INSURANCE CO/NY |
16,968 |
153,000 |
0.10% |
|
|
| 50 |
AMG National Trust Bank |
15,965 |
144,000 |
0.09% |
|
|
