| 1 |
Essex Woodlands Management, Inc. |
4,861,111 |
33,444,000 |
27.84% |
|
|
| 2 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
3,381,439 |
23,264,000 |
19.37% |
|
|
| 3 |
Opaleye Management Inc. |
2,120,000 |
14,586,000 |
12.14% |
|
|
| 4 |
Cortina Asset Management, LLC |
835,283 |
5,747,000 |
4.78% |
|
|
| 5 |
VANGUARD GROUP INC |
775,448 |
5,335,000 |
4.44% |
|
|
| 6 |
BlackRock Fund Advisors |
634,132 |
4,363,000 |
3.63% |
|
|
| 7 |
PERKINS CAPITAL MANAGEMENT INC |
631,908 |
4,348,000 |
3.62% |
|
|
| 8 |
Consonance Capital Management LP |
526,351 |
3,621,000 |
3.01% |
|
|
| 9 |
NEXT CENTURY GROWTH INVESTORS LLC |
353,482 |
2,431,000 |
2.02% |
|
|
| 10 |
Informed Momentum Co LLC |
318,478 |
2,191,000 |
1.82% |
|
|
| 11 |
DEUTSCHE BANK AG\ |
284,577 |
1,956,000 |
1.63% |
|
|
| 12 |
STATE STREET CORP |
274,222 |
1,885,000 |
1.57% |
|
|
| 13 |
NORTHERN TRUST CORP |
265,294 |
1,825,000 |
1.52% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
261,835 |
1,801,000 |
1.50% |
|
|
| 15 |
WADDELL & REED FINANCIAL INC |
199,288 |
1,371,000 |
1.14% |
|
|
| 16 |
Fiduciary Trust Co International of Pennsylvania |
188,498 |
1,297,000 |
1.08% |
|
|
| 17 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
180,350 |
1,241,000 |
1.03% |
|
|
| 18 |
RENAISSANCE TECHNOLOGIES LLC |
174,700 |
1,202,000 |
1.00% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
150,409 |
1,034,000 |
0.86% |
|
|
| 20 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
130,282 |
896,000 |
0.75% |
|
|
| 21 |
PROFICIO CAPITAL PARTNERS LLC |
116,266 |
781,000 |
0.65% |
|
|
| 22 |
BlackRock Investment Management, LLC |
89,667 |
617,000 |
0.51% |
|
|
| 23 |
Bank of New York Mellon Corp |
80,580 |
555,000 |
0.46% |
|
|
| 24 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
70,880 |
488,000 |
0.41% |
|
|
| 25 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
50,593 |
348,000 |
0.29% |
|
|
| 26 |
G2 Investment Partners Management LLC |
50,474 |
347,000 |
0.29% |
|
|
| 27 |
TEACHERS ADVISORS, LLC |
38,847 |
267,000 |
0.22% |
|
|
| 28 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
38,300 |
264,000 |
0.22% |
|
|
| 29 |
Virtu KCG Holdings LLC |
29,097 |
200,000 |
0.17% |
|
|
| 30 |
MENTA CAPITAL LLC |
26,555 |
183,000 |
0.15% |
|
|
| 31 |
NEW YORK STATE COMMON RETIREMENT FUND |
24,800 |
171,000 |
0.14% |
|
|
| 32 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
19,850 |
137,000 |
0.11% |
|
|
| 33 |
RHUMBLINE ADVISERS |
19,210 |
132,000 |
0.11% |
|
|
| 34 |
VOYA INVESTMENT MANAGEMENT LLC |
18,534 |
128,000 |
0.11% |
|
|
| 35 |
Commonwealth Equity Services, Inc |
17,711 |
122,000 |
0.10% |
|
|
| 36 |
TFS CAPITAL LLC |
16,465 |
113,000 |
0.09% |
|
|
| 37 |
AMG National Trust Bank |
15,965 |
110,000 |
0.09% |
|
|
| 38 |
Nationwide Fund Advisors |
15,201 |
105,000 |
0.09% |
|
|
| 39 |
GOLDMAN SACHS GROUP INC |
14,545 |
100,000 |
0.08% |
|
|
| 40 |
CREDIT SUISSE AG/ |
13,944 |
96,000 |
0.08% |
|
|
| 41 |
AMERICAN INTERNATIONAL GROUP, INC. |
13,889 |
95,556 |
0.08% |
|
|
| 42 |
LPL Financial LLC |
12,163 |
85,000 |
0.07% |
|
|
| 43 |
MORGAN STANLEY |
11,522 |
79,000 |
0.07% |
|
|
| 44 |
UBS Group AG |
10,800 |
74,000 |
0.06% |
|
|
| 45 |
BANK OF AMERICA CORP /DE/ |
9,977 |
69,000 |
0.06% |
|
|
| 46 |
DRILL CRAIG A |
10,000 |
69,000 |
0.06% |
|
|
| 47 |
WELLS FARGO & COMPANY/MN |
9,300 |
64,000 |
0.05% |
|
|
| 48 |
BLACKROCK ADVISORS LLC |
8,501 |
58,000 |
0.05% |
|
|
| 49 |
REILLY FINANCIAL ADVISORS, LLC |
8,000 |
55,000 |
0.05% |
|
|
| 50 |
STRS OHIO |
8,000 |
55,000 |
0.05% |
|
|
