| 1 |
Essex Woodlands Management, Inc. |
4,861,111 |
43,750,000 |
23.03% |
|
|
| 2 |
Opaleye Management Inc. |
1,970,000 |
17,730,000 |
9.33% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,838,225 |
16,544,000 |
8.71% |
|
|
| 4 |
VANGUARD GROUP INC |
1,086,748 |
9,781,000 |
5.15% |
|
|
| 5 |
Cortina Asset Management, LLC |
921,239 |
8,291,000 |
4.36% |
|
|
| 6 |
BlackRock Fund Advisors |
831,628 |
7,485,000 |
3.94% |
|
|
| 7 |
NEXT CENTURY GROWTH INVESTORS LLC |
672,668 |
6,054,000 |
3.19% |
|
|
| 8 |
PERKINS CAPITAL MANAGEMENT INC |
595,908 |
5,363,000 |
2.82% |
|
|
| 9 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
541,839 |
4,877,000 |
2.57% |
|
|
| 10 |
GILDER GAGNON HOWE & CO LLC |
442,338 |
3,981,000 |
2.10% |
|
|
| 11 |
COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT |
360,924 |
3,248,000 |
1.71% |
|
|
| 12 |
STATE STREET CORP |
352,735 |
3,175,000 |
1.67% |
|
|
| 13 |
Granite Point Capital Management, L.P. |
352,000 |
3,168,000 |
1.67% |
|
|
| 14 |
WADDELL & REED FINANCIAL INC |
349,288 |
3,144,000 |
1.65% |
|
|
| 15 |
AWM Investment Company, Inc. |
342,106 |
3,079,000 |
1.62% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
337,143 |
3,034,000 |
1.60% |
|
|
| 17 |
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC |
321,358 |
2,892,000 |
1.52% |
|
|
| 18 |
Informed Momentum Co LLC |
309,940 |
2,789,000 |
1.47% |
|
|
| 19 |
S Squared Technology, LLC |
302,614 |
2,724,000 |
1.43% |
|
|
| 20 |
NORTHERN TRUST CORP |
281,301 |
2,531,000 |
1.33% |
|
|
| 21 |
Allianz Asset Management GmbH |
259,279 |
2,334,000 |
1.23% |
|
|
| 22 |
Millrace Asset Group, Inc. |
220,000 |
1,980,000 |
1.04% |
|
|
| 23 |
RUSSELL INVESTMENTS GROUP, LTD. |
219,358 |
1,963,000 |
1.03% |
|
|
| 24 |
GEODE CAPITAL MANAGEMENT, LLC |
204,615 |
1,841,000 |
0.97% |
|
|
| 25 |
G2 Investment Partners Management LLC |
201,426 |
1,813,000 |
0.95% |
|
|
| 26 |
DEUTSCHE BANK AG\ |
196,107 |
1,764,000 |
0.93% |
|
|
| 27 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
180,400 |
1,624,000 |
0.85% |
|
|
| 28 |
SUFFOLK CAPITAL MANAGEMENT LLC |
175,084 |
1,576,000 |
0.83% |
|
|
| 29 |
EMERALD MUTUAL FUND ADVISERS TRUST |
165,807 |
1,492,000 |
0.79% |
|
|
| 30 |
Timpani Capital Management LLC |
163,684 |
1,473,000 |
0.78% |
|
|
| 31 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
141,909 |
1,277,000 |
0.67% |
|
|
| 32 |
Fiduciary Trust Co International of Pennsylvania |
135,115 |
1,216,000 |
0.64% |
|
|
| 33 |
WELLS FARGO & COMPANY/MN |
133,889 |
1,205,000 |
0.63% |
|
|
| 34 |
SCHONFELD STRATEGIC ADVISORS LLC |
120,000 |
1,080,000 |
0.57% |
|
|
| 35 |
Invesco Ltd. |
117,300 |
1,056,000 |
0.56% |
|
|
| 36 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
105,200 |
947,000 |
0.50% |
|
|
| 37 |
MENTA CAPITAL LLC |
102,538 |
923,000 |
0.49% |
|
|
| 38 |
MORGAN STANLEY |
101,194 |
911,000 |
0.48% |
|
|
| 39 |
BlackRock Investment Management, LLC |
90,071 |
811,000 |
0.43% |
|
|
| 40 |
Bank of New York Mellon Corp |
89,320 |
804,000 |
0.42% |
|
|
| 41 |
PROFICIO CAPITAL PARTNERS LLC |
87,200 |
785,000 |
0.41% |
|
|
| 42 |
JPMORGAN CHASE & CO |
81,536 |
734,000 |
0.39% |
|
|
| 43 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
75,274 |
677,000 |
0.36% |
|
|
| 44 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
69,769 |
628,000 |
0.33% |
|
|
| 45 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
54,193 |
488,000 |
0.26% |
|
|
| 46 |
TEACHERS ADVISORS, LLC |
48,740 |
439,000 |
0.23% |
|
|
| 47 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
38,300 |
345,000 |
0.18% |
|
|
| 48 |
TWO SIGMA INVESTMENTS, LP |
37,904 |
341,000 |
0.18% |
|
|
| 49 |
FNY PARTNERS FUND LP |
25,500 |
230,000 |
0.12% |
|
|
| 50 |
NEW YORK STATE COMMON RETIREMENT FUND |
24,800 |
223,000 |
0.12% |
|
|
