| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,171,948 | 750,578,000 | 22.01% | ||
| 2 | ORBIMED ADVISORS LLC | 1,656,258 | 391,298,000 | 11.47% | ||
| 3 | JENNISON ASSOCIATES LLC | 1,427,118 | 337,699,000 | 9.90% | ||
| 4 | Carmignac Gestion | 1,000,576 | 236,766,000 | 6.94% | ||
| 5 | Capital World Investors | 736,800 | 174,349,000 | 5.11% | ||
| 6 | VANGUARD GROUP INC | 650,073 | 153,826,000 | 4.51% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 622,030 | 147,191,000 | 4.32% | ||
| 8 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 460,100 | 108,874,000 | 3.19% | Put | |
| 9 | BlackRock Institutional Trust Company, N.A. | 299,364 | 70,839,000 | 2.08% | ||
| 10 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 272,800 | 64,553,000 | 1.89% | Call | |
| 11 | GOLDMAN SACHS GROUP INC | 235,300 | 55,679,000 | 1.63% | Put | |
| 12 | VIKING GLOBAL INVESTORS LP | 208,077 | 49,237,000 | 1.44% | ||
| 13 | LORD, ABBETT & CO. LLC | 204,635 | 48,423,000 | 1.42% | ||
| 14 | FRANKLIN RESOURCES INC | 190,100 | 44,983,000 | 1.32% | ||
| 15 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 183,300 | 43,374,000 | 1.27% | ||
| 16 | STATE STREET CORP | 175,917 | 41,631,000 | 1.22% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 166,195 | 39,326,000 | 1.15% | ||
| 18 | GILDER GAGNON HOWE & CO LLC | 145,297 | 34,382,000 | 1.01% | ||
| 19 | JENNISON ASSOCIATES LLC | 130,000 | 30,762,000 | 0.90% | Put | |
| 20 | NORGES BANK | 123,083 | 29,125,000 | 0.85% | ||
| 21 | NORTHERN TRUST CORP | 101,221 | 23,951,000 | 0.70% | ||
| 22 | FRED ALGER MANAGEMENT, LLC | 98,162 | 23,228,000 | 0.68% | ||
| 23 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 89,200 | 21,107,000 | 0.62% | ||
| 24 | BANK OF AMERICA CORP /DE/ | 86,819 | 20,544,000 | 0.60% | ||
| 25 | MORGAN STANLEY | 84,844 | 20,076,000 | 0.59% | ||
| 26 | BlackRock Fund Advisors | 81,970 | 19,397,000 | 0.57% | ||
| 27 | Invesco Ltd. | 75,049 | 17,759,000 | 0.52% | ||
| 28 | SECTORAL ASSET MANAGEMENT INC | 73,993 | 17,509,000 | 0.51% | ||
| 29 | ALLIANCEBERNSTEIN L.P. | 64,229 | 15,199,000 | 0.45% | ||
| 30 | MILLENNIUM MANAGEMENT LLC | 61,700 | 14,600,000 | 0.43% | Call | |
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 61,518 | 14,557,000 | 0.43% | ||
| 32 | AMERIPRISE FINANCIAL INC | 61,128 | 14,465,000 | 0.42% | ||
| 33 | ALTRINSIC GLOBAL ADVISORS LLC | 50,800 | 12,021,000 | 0.35% | ||
| 34 | GOLDMAN SACHS GROUP INC | 49,799 | 11,784,000 | 0.35% | ||
| 35 | RUSSELL FRANK CO/ | 46,810 | 10,872,000 | 0.32% | ||
| 36 | BARCLAYS PLC | 45,000 | 10,620,000 | 0.31% | Put | |
| 37 | NOMURA HOLDINGS INC | 41,739 | 10,064,000 | 0.30% | ||
| 38 | SUFFOLK CAPITAL MANAGEMENT LLC | 42,148 | 9,973,000 | 0.29% | ||
| 39 | DRIEHAUS CAPITAL MANAGEMENT LLC | 41,949 | 9,926,000 | 0.29% | ||
| 40 | VAN ECK ASSOCIATES CORP | 37,407 | 8,852,000 | 0.26% | ||
| 41 | Bank of New York Mellon Corp | 36,330 | 8,597,000 | 0.25% | ||
| 42 | PICTON MAHONEY ASSET MANAGEMENT | 34,050 | 8,057,000 | 0.24% | SH | |
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 33,697 | 7,974,000 | 0.23% | ||
| 44 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 31,874 | 7,542,000 | 0.22% | ||
| 45 | HBK INVESTMENTS L P | 28,100 | 6,649,000 | 0.19% | ||
| 46 | GUGGENHEIM CAPITAL LLC | 26,863 | 6,357,000 | 0.19% | ||
| 47 | Point72 Asset Management, L.P. | 26,500 | 6,271,000 | 0.18% | ||
| 48 | Weiss Multi-Strategy Advisers LLC | 26,000 | 6,152,000 | 0.18% | ||
| 49 | EMERALD ADVISERS, LLC | 25,113 | 5,942,000 | 0.17% | ||
| 50 | CAPITAL FUND MANAGEMENT S.A. | 24,673 | 5,838,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
