| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,203,951 | 499,816,000 | 18.78% | ||
| 2 | ORBIMED ADVISORS LLC | 1,485,000 | 231,660,000 | 8.70% | ||
| 3 | Carmignac Gestion | 1,432,071 | 223,403,000 | 8.39% | ||
| 4 | Capital World Investors | 860,000 | 172,886,000 | 6.50% | ||
| 5 | VANGUARD GROUP INC | 753,676 | 117,573,000 | 4.42% | ||
| 6 | FRANKLIN RESOURCES INC | 590,107 | 92,057,000 | 3.46% | ||
| 7 | JENNISON ASSOCIATES LLC | 468,341 | 73,061,000 | 2.75% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 452,313 | 70,561,000 | 2.65% | ||
| 9 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 437,200 | 68,203,000 | 2.56% | Put | |
| 10 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 393,850 | 61,441,000 | 2.31% | ||
| 11 | BlackRock Fund Advisors | 344,342 | 53,717,000 | 2.02% | ||
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 341,244 | 53,234,000 | 2.00% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 318,941 | 49,755,000 | 1.87% | ||
| 14 | ALTRINSIC GLOBAL ADVISORS LLC | 301,769 | 47,076,000 | 1.77% | ||
| 15 | Point72 Asset Management, L.P. | 300,200 | 46,831,000 | 1.76% | ||
| 16 | FIRST TRUST ADVISORS LP | 277,185 | 43,241,000 | 1.62% | ||
| 17 | STATE STREET CORP | 265,086 | 41,356,000 | 1.55% | ||
| 18 | FRED ALGER MANAGEMENT, LLC | 259,934 | 40,550,000 | 1.52% | ||
| 19 | PRICE T ROWE ASSOCIATES INC /MD/ | 256,202 | 39,968,000 | 1.50% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 189,700 | 29,593,000 | 1.11% | Call | |
| 21 | SECTORAL ASSET MANAGEMENT INC | 181,847 | 28,368,000 | 1.07% | ||
| 22 | CREDIT AGRICOLE S A | 177,018 | 27,845,000 | 1.05% | ||
| 23 | NORGES BANK | 123,083 | 19,201,000 | 0.72% | ||
| 24 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 122,425 | 19,099,000 | 0.72% | ||
| 25 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 120,000 | 18,720,000 | 0.70% | ||
| 26 | Invesco Ltd. | 118,151 | 18,431,000 | 0.69% | ||
| 27 | MORGAN STANLEY | 109,416 | 17,069,000 | 0.64% | ||
| 28 | RUSSELL FRANK CO/ | 100,754 | 15,729,000 | 0.59% | ||
| 29 | COLUMBUS CIRCLE INVESTORS | 93,130 | 14,528,000 | 0.55% | ||
| 30 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 86,212 | 13,449,072 | 0.51% | ||
| 31 | AMERIPRISE FINANCIAL INC | 78,005 | 12,171,000 | 0.46% | ||
| 32 | BANK OF AMERICA CORP /DE/ | 76,255 | 11,896,000 | 0.45% | ||
| 33 | SUFFOLK CAPITAL MANAGEMENT LLC | 75,607 | 11,795,000 | 0.44% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 70,000 | 10,920,000 | 0.41% | Put | |
| 35 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 69,073 | 10,775,000 | 0.40% | ||
| 36 | EMERALD ADVISERS, LLC | 67,415 | 10,517,000 | 0.40% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 64,427 | 10,050,000 | 0.38% | ||
| 38 | SENZAR ASSET MANAGEMENT, LLC | 61,900 | 9,656,000 | 0.36% | ||
| 39 | AXA S.A. | 60,645 | 9,461,000 | 0.36% | ||
| 40 | DEERFIELD MANAGEMENT COMPANY, L.P. | 60,393 | 9,421,000 | 0.35% | ||
| 41 | CREDIT SUISSE AG/ | 56,116 | 8,754,000 | 0.33% | ||
| 42 | JPMORGAN CHASE & CO | 54,817 | 8,551,000 | 0.32% | ||
| 43 | GOLDMAN SACHS GROUP INC | 53,259 | 8,308,000 | 0.31% | ||
| 44 | GUGGENHEIM CAPITAL LLC | 50,782 | 7,922,000 | 0.30% | ||
| 45 | NORTHERN TRUST CORP | 47,191 | 7,362,000 | 0.28% | ||
| 46 | DEUTSCHE BANK AG\ | 46,823 | 7,303,000 | 0.27% | ||
| 47 | BARCLAYS PLC | 46,089 | 7,189,000 | 0.27% | ||
| 48 | Bank of New York Mellon Corp | 44,462 | 6,937,000 | 0.26% | ||
| 49 | RAINIER INVESTMENT MANAGEMENT LLC | 43,740 | 6,823,000 | 0.26% | ||
| 50 | Allianz Asset Management GmbH | 42,885 | 6,690,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
