| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,889,269 | 952,852,000 | 22.48% | ||
| 2 | ORBIMED ADVISORS LLC | 1,734,934 | 572,164,000 | 13.50% | ||
| 3 | JENNISON ASSOCIATES LLC | 1,138,177 | 375,359,000 | 8.86% | ||
| 4 | Capital World Investors | 1,004,751 | 331,357,000 | 7.82% | ||
| 5 | VANGUARD GROUP INC | 580,699 | 191,509,000 | 4.52% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 567,640 | 187,202,000 | 4.42% | ||
| 7 | VIKING GLOBAL INVESTORS LP | 454,917 | 150,027,000 | 3.54% | ||
| 8 | BAKER BROS. ADVISORS LP | 256,375 | 84,550,000 | 1.99% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 234,731 | 77,412,000 | 1.83% | ||
| 10 | BlackRock Fund Advisors | 200,442 | 66,104,000 | 1.56% | ||
| 11 | Artisan Partners Limited Partnership | 175,733 | 57,955,000 | 1.37% | ||
| 12 | STATE STREET CORP | 165,933 | 54,723,000 | 1.29% | ||
| 13 | ALLIANCEBERNSTEIN L.P. | 156,067 | 51,469,000 | 1.21% | ||
| 14 | GILDER GAGNON HOWE & CO LLC | 148,056 | 48,827,000 | 1.15% | ||
| 15 | FRANKLIN RESOURCES INC | 142,100 | 46,863,000 | 1.11% | ||
| 16 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 133,000 | 43,862,000 | 1.03% | ||
| 17 | NORTHERN TRUST CORP | 115,091 | 37,955,000 | 0.90% | ||
| 18 | Invesco Ltd. | 106,848 | 35,237,000 | 0.83% | ||
| 19 | GOLDMAN SACHS GROUP INC | 103,800 | 34,232,000 | 0.81% | Call | |
| 20 | Visium Asset Management, LP | 100,100 | 33,012,000 | 0.78% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 99,441 | 32,795,000 | 0.77% | ||
| 22 | EAGLE ASSET MANAGEMENT INC | 93,021 | 30,677,000 | 0.72% | ||
| 23 | BARCLAYS PLC | 91,500 | 30,104,000 | 0.71% | Call | |
| 24 | MORGAN STANLEY | 82,449 | 27,191,000 | 0.64% | ||
| 25 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 82,200 | 27,109,000 | 0.64% | ||
| 26 | SECTORAL ASSET MANAGEMENT INC | 74,493 | 24,567,000 | 0.58% | ||
| 27 | FRED ALGER MANAGEMENT, LLC | 71,006 | 23,417,000 | 0.55% | ||
| 28 | PFM Health Sciences, LP | 66,571 | 21,954,000 | 0.52% | ||
| 29 | BANK OF AMERICA CORP /DE/ | 64,161 | 21,160,000 | 0.50% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,295 | 19,884,000 | 0.47% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 58,973 | 19,448,000 | 0.46% | ||
| 32 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 55,264 | 18,226,000 | 0.43% | ||
| 33 | PICTON MAHONEY ASSET MANAGEMENT | 53,650 | 17,692,000 | 0.42% | SH | |
| 34 | Redmile Group, LLC | 51,113 | 16,857,000 | 0.40% | ||
| 35 | ALTRINSIC GLOBAL ADVISORS LLC | 50,800 | 16,753,000 | 0.40% | ||
| 36 | Cormorant Asset Management, LP | 50,000 | 16,490,000 | 0.39% | ||
| 37 | BARCLAYS PLC | 49,200 | 16,187,000 | 0.38% | Put | |
| 38 | JPMORGAN CHASE & CO | 48,837 | 16,107,000 | 0.38% | ||
| 39 | MILLENNIUM MANAGEMENT LLC | 48,000 | 15,830,000 | 0.37% | Call | |
| 40 | DRIEHAUS CAPITAL MANAGEMENT LLC | 47,136 | 15,545,000 | 0.37% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 41,753 | 13,770,000 | 0.32% | ||
| 42 | Bank of New York Mellon Corp | 40,971 | 13,512,000 | 0.32% | ||
| 43 | RS INVESTMENT MANAGEMENT CO LLC | 39,261 | 12,948,000 | 0.31% | ||
| 44 | NORGES BANK | 37,083 | 12,230,000 | 0.29% | ||
| 45 | BENNETT LAWRENCE MANAGEMENT L L C/NY | 35,812 | 11,810,000 | 0.28% | ||
| 46 | GOLDMAN SACHS GROUP INC | 34,600 | 11,411,000 | 0.27% | Put | |
| 47 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 32,000 | 10,553,000 | 0.25% | ||
| 48 | D. E. Shaw & Co., Inc. | 30,300 | 9,993,000 | 0.24% | Put | |
| 49 | Weiss Multi-Strategy Advisers LLC | 29,200 | 9,630,000 | 0.23% | ||
| 50 | VAN ECK ASSOCIATES CORP | 29,155 | 9,615,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
