| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,583,086 | 1,010,502,000 | 18.68% | ||
| 2 | Carmignac Gestion | 1,349,387 | 380,554,000 | 7.04% | ||
| 3 | ORBIMED ADVISORS LLC | 1,120,000 | 315,862,000 | 5.84% | ||
| 4 | VANGUARD GROUP INC | 954,574 | 269,209,000 | 4.98% | ||
| 5 | AMERIPRISE FINANCIAL INC | 823,608 | 232,271,000 | 4.29% | ||
| 6 | Capital World Investors | 780,000 | 219,976,000 | 4.07% | ||
| 7 | FIRST TRUST ADVISORS LP | 638,274 | 180,006,000 | 3.33% | ||
| 8 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 555,700 | 156,719,000 | 2.90% | Put | |
| 9 | FRED ALGER MANAGEMENT, LLC | 482,739 | 136,142,000 | 2.52% | ||
| 10 | JENNISON ASSOCIATES LLC | 465,462 | 131,270,000 | 2.43% | ||
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 434,100 | 122,425,000 | 2.26% | Call | |
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 405,087 | 114,243,000 | 2.11% | ||
| 13 | BlackRock Fund Advisors | 393,324 | 110,925,000 | 2.05% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 343,772 | 96,951,000 | 1.79% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 328,856 | 92,744,000 | 1.71% | ||
| 16 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 315,850 | 89,076,000 | 1.65% | ||
| 17 | FRANKLIN RESOURCES INC | 275,991 | 77,835,000 | 1.44% | ||
| 18 | Alpha Wave Global, LP | 275,000 | 77,556,000 | 1.43% | ||
| 19 | JPMORGAN CHASE & CO | 274,566 | 77,433,000 | 1.43% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 244,189 | 68,866,000 | 1.27% | ||
| 21 | ALTRINSIC GLOBAL ADVISORS LLC | 238,760 | 67,335,000 | 1.25% | ||
| 22 | STATE STREET CORP | 228,463 | 64,420,000 | 1.19% | ||
| 23 | CREDIT AGRICOLE S A | 173,018 | 48,795,000 | 0.90% | ||
| 24 | SECTORAL ASSET MANAGEMENT INC | 164,947 | 46,518,000 | 0.86% | ||
| 25 | BB BIOTECH AG | 155,000 | 43,713,000 | 0.81% | ||
| 26 | COLUMBUS CIRCLE INVESTORS | 134,777 | 38,010,000 | 0.70% | ||
| 27 | DEUTSCHE BANK AG\ | 133,451 | 37,633,000 | 0.70% | ||
| 28 | Point72 Asset Management, L.P. | 132,300 | 37,311,000 | 0.69% | ||
| 29 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 128,525 | 36,247,000 | 0.67% | ||
| 30 | NORGES BANK | 128,155 | 36,142,000 | 0.67% | ||
| 31 | BLACKROCK ADVISORS LLC | 121,105 | 34,154,000 | 0.63% | ||
| 32 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 111,975 | 31,579,000 | 0.58% | ||
| 33 | MORGAN STANLEY | 103,847 | 29,287,000 | 0.54% | ||
| 34 | CITADEL ADVISORS LLC | 103,463 | 29,179,000 | 0.54% | ||
| 35 | MANAGED ACCOUNT ADVISORS LLC | 95,860 | 27,034,000 | 0.50% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 89,349 | 25,198,000 | 0.47% | ||
| 37 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 88,198 | 24,873,600 | 0.46% | ||
| 38 | FARALLON CAPITAL MANAGEMENT LLC | 85,600 | 24,141,000 | 0.45% | ||
| 39 | GOLDMAN SACHS GROUP INC | 85,300 | 24,056,000 | 0.44% | Put | |
| 40 | GOLDMAN SACHS GROUP INC | 84,200 | 23,746,000 | 0.44% | Call | |
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 74,833 | 21,104,000 | 0.39% | ||
| 42 | LORD, ABBETT & CO. LLC | 72,428 | 20,426,000 | 0.38% | ||
| 43 | MILLENNIUM MANAGEMENT LLC | 70,000 | 19,741,000 | 0.37% | Call | |
| 44 | AXA S.A. | 68,319 | 19,267,000 | 0.36% | ||
| 45 | CREDIT SUISSE AG/ | 65,440 | 18,455,000 | 0.34% | ||
| 46 | EMERALD ADVISERS, LLC | 68,180 | 18,217,000 | 0.34% | ||
| 47 | TIAA CREF INVESTMENT MANAGEMENT LLC | 60,947 | 17,188,000 | 0.32% | ||
| 48 | D. E. Shaw & Co., Inc. | 59,000 | 16,639,000 | 0.31% | Put | |
| 49 | Bank of New York Mellon Corp | 58,420 | 16,475,000 | 0.30% | ||
| 50 | CITIGROUP INC | 56,613 | 15,967,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
