| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,182,693 | 753,312,000 | 22.63% | ||
| 2 | ORBIMED ADVISORS LLC | 1,485,000 | 351,485,000 | 10.56% | ||
| 3 | Carmignac Gestion | 1,330,516 | 314,920,000 | 9.46% | ||
| 4 | Capital World Investors | 736,800 | 174,393,000 | 5.24% | ||
| 5 | VANGUARD GROUP INC | 728,242 | 172,367,000 | 5.18% | ||
| 6 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 511,600 | 121,091,000 | 3.64% | Put | |
| 7 | FRANKLIN RESOURCES INC | 328,757 | 77,813,000 | 2.34% | ||
| 8 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 316,512 | 74,915,000 | 2.25% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 307,894 | 72,875,000 | 2.19% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 302,012 | 71,483,000 | 2.15% | ||
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 283,400 | 67,078,000 | 2.01% | Call | |
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 262,586 | 62,151,000 | 1.87% | ||
| 13 | JENNISON ASSOCIATES LLC | 260,195 | 61,586,000 | 1.85% | ||
| 14 | STATE STREET CORP | 197,329 | 46,708,000 | 1.40% | ||
| 15 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 183,300 | 43,385,000 | 1.30% | ||
| 16 | LORD, ABBETT & CO. LLC | 180,491 | 42,720,000 | 1.28% | ||
| 17 | COLUMBUS CIRCLE INVESTORS | 153,808 | 36,405,000 | 1.09% | ||
| 18 | GILDER GAGNON HOWE & CO LLC | 152,444 | 36,082,000 | 1.08% | ||
| 19 | Bank of New York Mellon Corp | 128,368 | 30,382,000 | 0.91% | ||
| 20 | MORGAN STANLEY | 124,698 | 29,514,000 | 0.89% | ||
| 21 | NORGES BANK | 123,083 | 29,132,000 | 0.88% | ||
| 22 | DEERFIELD MANAGEMENT COMPANY, L.P. | 98,693 | 23,360,000 | 0.70% | ||
| 23 | BlackRock Fund Advisors | 97,316 | 23,034,000 | 0.69% | ||
| 24 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 93,125 | 22,041,000 | 0.66% | ||
| 25 | AMERIPRISE FINANCIAL INC | 90,559 | 21,435,000 | 0.64% | ||
| 26 | BANK OF AMERICA CORP /DE/ | 83,970 | 19,875,000 | 0.60% | ||
| 27 | Invesco Ltd. | 82,087 | 19,429,000 | 0.58% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 80,000 | 18,935,000 | 0.57% | Put | |
| 29 | RUSSELL FRANK CO/ | 79,960 | 18,926,000 | 0.57% | ||
| 30 | FRED ALGER MANAGEMENT, LLC | 79,772 | 18,881,000 | 0.57% | ||
| 31 | SECTORAL ASSET MANAGEMENT INC | 77,893 | 18,436,000 | 0.55% | ||
| 32 | SUFFOLK CAPITAL MANAGEMENT LLC | 62,529 | 14,800,000 | 0.44% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 62,350 | 14,757,000 | 0.44% | ||
| 34 | GOLDMAN SACHS GROUP INC | 60,400 | 14,296,000 | 0.43% | Put | |
| 35 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 59,018 | 13,969,000 | 0.42% | ||
| 36 | GOLDMAN SACHS GROUP INC | 50,800 | 12,024,000 | 0.36% | Call | |
| 37 | ALTRINSIC GLOBAL ADVISORS LLC | 50,800 | 12,024,000 | 0.36% | ||
| 38 | NOMURA HOLDINGS INC | 50,216 | 11,955,000 | 0.36% | ||
| 39 | DEERFIELD MANAGEMENT COMPANY, L.P. | 50,000 | 11,835,000 | 0.36% | Call | |
| 40 | NORTHERN TRUST CORP | 47,972 | 11,354,000 | 0.34% | ||
| 41 | TURNER INVESTMENTS LLC | 47,189 | 11,169,000 | 0.34% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 42,365 | 10,027,000 | 0.30% | ||
| 43 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 41,000 | 9,704,000 | 0.29% | ||
| 44 | CREDIT SUISSE AG/ | 38,628 | 9,143,000 | 0.27% | ||
| 45 | Point72 Asset Management, L.P. | 37,300 | 8,829,000 | 0.27% | ||
| 46 | VAN ECK ASSOCIATES CORP | 36,988 | 8,755,000 | 0.26% | ||
| 47 | TWO SIGMA INVESTMENTS, LP | 35,299 | 8,355,000 | 0.25% | ||
| 48 | BARCLAYS PLC | 30,400 | 7,174,000 | 0.22% | Put | |
| 49 | Artisan Partners Limited Partnership | 30,050 | 7,113,000 | 0.21% | ||
| 50 | GUGGENHEIM CAPITAL LLC | 29,510 | 6,985,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
