| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,630,324 | 602,126,000 | 18.58% | ||
| 2 | AMERIPRISE FINANCIAL INC | 1,846,894 | 306,234,000 | 9.45% | ||
| 3 | Capital World Investors | 1,410,937 | 234,018,000 | 7.22% | ||
| 4 | Carmignac Gestion | 1,319,507 | 218,853,000 | 6.75% | ||
| 5 | ORBIMED ADVISORS LLC | 1,120,000 | 185,763,000 | 5.73% | ||
| 6 | VANGUARD GROUP INC | 1,051,563 | 174,412,000 | 5.38% | ||
| 7 | BlackRock Fund Advisors | 488,177 | 80,969,000 | 2.50% | ||
| 8 | FIRST TRUST ADVISORS LP | 464,373 | 77,021,000 | 2.38% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 406,997 | 67,505,000 | 2.08% | ||
| 10 | FRED ALGER MANAGEMENT, LLC | 395,837 | 65,654,000 | 2.03% | ||
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 359,800 | 59,677,000 | 1.84% | Put | |
| 12 | JENNISON ASSOCIATES LLC | 346,005 | 57,388,000 | 1.77% | ||
| 13 | PRICE T ROWE ASSOCIATES INC /MD/ | 339,506 | 56,310,000 | 1.74% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 328,200 | 54,435,000 | 1.68% | Call | |
| 15 | BANK OF AMERICA CORP /DE/ | 319,843 | 53,049,000 | 1.64% | ||
| 16 | STATE STREET CORP | 317,787 | 52,712,000 | 1.63% | ||
| 17 | JPMORGAN CHASE & CO | 305,428 | 50,659,000 | 1.56% | ||
| 18 | FRANKLIN RESOURCES INC | 275,991 | 45,776,000 | 1.41% | ||
| 19 | COLUMBUS CIRCLE INVESTORS | 266,308 | 44,170,000 | 1.36% | ||
| 20 | CREDIT AGRICOLE S A | 223,643 | 37,093,000 | 1.14% | ||
| 21 | SECTORAL ASSET MANAGEMENT INC | 219,647 | 36,431,000 | 1.12% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 217,637 | 36,098,000 | 1.11% | ||
| 23 | BB BIOTECH AG | 210,719 | 34,950,000 | 1.08% | ||
| 24 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 209,818 | 34,800,000 | 1.07% | ||
| 25 | ALTRINSIC GLOBAL ADVISORS LLC | 184,688 | 30,632,000 | 0.95% | ||
| 26 | DEUTSCHE BANK AG\ | 172,583 | 28,621,000 | 0.88% | ||
| 27 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 136,626 | 22,661,000 | 0.70% | ||
| 28 | NORGES BANK | 122,873 | 20,380,000 | 0.63% | ||
| 29 | BLACKROCK ADVISORS LLC | 118,813 | 19,706,000 | 0.61% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 102,874 | 17,062,000 | 0.53% | ||
| 31 | HIGHFIELDS CAPITAL MANAGEMENT LP | 93,926 | 15,579,000 | 0.48% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 89,688 | 14,876,000 | 0.46% | ||
| 33 | D. E. Shaw & Co., Inc. | 89,000 | 14,762,000 | 0.46% | Put | |
| 34 | AXA S.A. | 85,009 | 14,100,000 | 0.44% | ||
| 35 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 77,000 | 12,771,000 | 0.39% | ||
| 36 | NORTHERN TRUST CORP | 72,452 | 12,017,000 | 0.37% | ||
| 37 | GLG LLC | 72,047 | 11,950,000 | 0.37% | ||
| 38 | Bank of New York Mellon Corp | 71,109 | 11,795,000 | 0.36% | ||
| 39 | EMERALD ADVISERS, LLC | 69,398 | 11,510,000 | 0.36% | ||
| 40 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 65,093 | 10,796,000 | 0.33% | ||
| 41 | TEACHERS ADVISORS, LLC | 61,943 | 10,274,000 | 0.32% | ||
| 42 | RENAISSANCE TECHNOLOGIES LLC | 61,600 | 10,217,000 | 0.32% | ||
| 43 | GUGGENHEIM CAPITAL LLC | 57,656 | 9,563,000 | 0.30% | ||
| 44 | CREDIT SUISSE AG/ | 54,924 | 9,108,000 | 0.28% | ||
| 45 | PICTET ASSET MANAGEMENT LTD | 48,701 | 8,078,000 | 0.25% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 47,282 | 7,843,000 | 0.24% | ||
| 47 | LORD, ABBETT & CO. LLC | 45,835 | 7,602,000 | 0.23% | ||
| 48 | EMERALD MUTUAL FUND ADVISERS TRUST | 45,820 | 7,600,000 | 0.23% | ||
| 49 | LMCG INVESTMENTS, LLC | 40,971 | 6,795,000 | 0.21% | ||
| 50 | VAN ECK ASSOCIATES CORP | 40,558 | 6,727,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
